Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) and Related Transcription-Activating Deoxyribonucleic Acid-Binding Proteins*

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA

1988 • 677 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

A Plant Leucine Zipper Protein That Recognizes an Abscisic Acid Response Element

1990 • 640 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

Developmental switch of CREM function during spermatogenesis: from antagonist to activator

1992 • 495 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Two tobacco DNA-binding proteins with homology to the nuclear factor CREB

1989 • 462 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

Maize regulatory gene opaque-2 encodes a protein with a "leucine-zipper" motif that binds to zein DNA.

1990 • 443 citations

Mechanism of specificity in the Fos-Jun oncoprotein heterodimer

1992 • 422 citations

Regulation of camp-inducible genes by creb

1990 • 416 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

1985 • 391 citations

Modularity in promoters and enhancers

1989 • 366 citations

Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

1990 • 355 citations

Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos

1992 • 348 citations

Heterodimer formation between CREB and JUN proteins.

1990 • 347 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

1987 • 328 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

A conserved retina-specific gene encodes a basic motif/leucine zipper domain.

1992 • 308 citations

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

1991 • 302 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

A New Member of the Leucine Zipper Class of Proteins that Binds to the HLA DRα Promoter

1990 • 286 citations

Molecular cloning and characterization of a human DNA binding factor that represses transcription

1989 • 285 citations

More is better: Activators and repressors from the same gene

1992 • 280 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

cAMP-dependent Protein Kinase

1989 • 274 citations

Isolation and characterization of fra-2, an additional member of the fos gene family.

1990 • 274 citations

Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP.

1990 • 272 citations

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

1993 • 272 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins.

1992 • 261 citations

Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.

1992 • 260 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.

1991 • 246 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.

1990 • 237 citations

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

1991 • 229 citations

Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription.

1992 • 229 citations

Characterization of a bipartite activator domain in transcription factor CREB

1990 • 228 citations

Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

1990 • 226 citations

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

1991 • 224 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1

1990 • 221 citations

Control of transcription activation by steroid hormone receptors

1992 • 218 citations

Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues

1990 • 215 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

1990 • 210 citations

The steroid receptor superfamily: mechanisms of diversity

1991 • 202 citations

A tobacco bZip transcription activator (TAF-1) binds to a G-box-like motif conserved in plant genes.

1991 • 199 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

1992 • 189 citations

Transcriptional repression by a novel member of the bZIP family of transcription factors.

1992 • 182 citations

Casein kinase II enhances the DNA binding activity of serum response factor.

1990 • 181 citations

A Protein That Binds to a cis-acting Element of Wheat Histone Genes Has a Leucine Zipper Motif

1989 • 174 citations

Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.

1990 • 168 citations

Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.

1990 • 165 citations

In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.

1991 • 156 citations

Distinct Adenosine 3′,5′-Monophosphate and Phorbol Ester-Responsive Signal Transduction Pathways Converge at the Level of Transcriptional Activation by the Interactions of DNA-Binding Proteins

1989 • 151 citations

The acidic activation domains of the GCN4 and GAL4 proteins are not α helical but form β sheets

1993 • 151 citations

Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver.

1991 • 139 citations

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.

1989 • 135 citations

Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

1990 • 132 citations

The basic region of Fos mediates specific DNA binding.

1989 • 132 citations

Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions.

1992 • 131 citations

The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells.

1992 • 128 citations

Evidence of Changes in Protease Sensitivity and Subunit Exchange Rate on DNA Binding by C/EBP

1990 • 127 citations

Expression of the human androgen receptor gene utilizes a common promoter in diverse human tissues and cell lines.

1990 • 126 citations

The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor.

1990 • 123 citations

A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements.

1992 • 120 citations

Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression.

1991 • 108 citations

Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells

1990 • 103 citations

Identification of Multiple Nuclear Factors That Interact with Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and Activating Transcription Factor-2 by Protein-Protein Interactions

1991 • 103 citations

Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP.

1989 • 103 citations

Extracellular signals, transcriptional responses and cellular specificity

1989 • 98 citations

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.

1990 • 98 citations

Molecular Zippers in Gene Regulation

1991 • 97 citations

TGF-beta 1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCl64 cells.

1991 • 88 citations

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

1991 • 79 citations

Multiple Adenosine 3′,5′- Monophosphate Response Element DNA-Binding Proteins Generated by Gene Diversification and Alternative Exon Splicing

1990 • 69 citations

Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene.

1988 • 67 citations

Higher levels of control: modulation of steroid hormone-regulated gene transcription.

1992 • 67 citations

Phosphorylation of cellular proteins regulates their binding to the cAMP response element

1989 • 66 citations

Cyclic AMP response element-binding protein, CRE-BP1, mediates the E1A-induced but not the Tax-induced trans-activation.

1991 • 60 citations

Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element.

1992 • 50 citations

Identification of the functional domains of the transcriptional regulator CRE-BP1.

1991 • 45 citations

CREB represses transcription of fos promoter: role of phosphorylation.

1991 • 44 citations

Novel testis germ cell-specific transcript of the CREB gene contains an alternatively spliced exon with multiple in-frame stop codons.

1992 • 37 citations

Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors.

1991 • 33 citations

Assignment of the human gene for CREB1 to chromosome 2q32.3–q34

1990 • 30 citations

Fos, Jun and CREB basic-domain peptides have intrinsic DNA-binding activity enhanced by a novel stabilizing factor.

1990 • 30 citations

Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes

1992 • 28 citations

Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter

1990 • 28 citations

Mutagenesis of the DNA contact site in Fos protein: compatibility with the scissors grip model and requirement for transformation.

1991 • 21 citations

Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA

1991 • 7 citations

Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing.

1990 • 3 citations