Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

1983 • 532 citations

fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.

1988 • 518 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun

1989 • 469 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

Dimers, leucine zippers and DNA-binding domains

1990 • 377 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.

1990 • 168 citations

Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.

1989 • 164 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

Evidence of Changes in Protease Sensitivity and Subunit Exchange Rate on DNA Binding by C/EBP

1990 • 127 citations

fra-1: a Serum-Inducible, Cellular Immediate-Early Gene That Encodes a Fos-Related Antigen

1988 • 115 citations

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping "leucine zippers"

1989 • 90 citations

A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site

1989 • 77 citations

Jun DNA-binding is modulated by mutations between the leucines or by direct interaction of fos with the TGACTCA sequence.

1989 • 33 citations

Inactivation of the N-myc gene product by single amino acid substitution of leucine residues located in the leucine-zipper region.

1989 • 21 citations

Integrity of FOS B leucine zipper is essential for its interaction with JUN proteins.

1990 • 17 citations

Mapping of functional domains in Fos and Jun proteins using epitope-specific antibodies.

1990 • 9 citations