Distinct Adenosine 3′,5′-Monophosphate and Phorbol Ester-Responsive Signal Transduction Pathways Converge at the Level of Transcriptional Activation by the Interactions of DNA-Binding Proteins

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

1980 • 1,285 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

Human growth hormone as a reporter gene in regulation studies employing transient gene expression.

1986 • 667 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1987 • 524 citations

Acid blobs and negative noodles

1988 • 438 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters

1987 • 379 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

1987 • 321 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Mutants of GAL4 protein altered in an activation function

1987 • 281 citations

Structural determinants for transcriptional activation by cAMP-responsive DNA elements.

1988 • 258 citations

Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.

1987 • 236 citations

Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.

1987 • 216 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins.

1988 • 198 citations

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

1988 • 196 citations

Metallothionein gene expression is regulated by serum factors and activators of protein kinase C.

1987 • 156 citations

Recombinant Fragment of Protein Kinase Inhibitor Blocks Cyclic AMP-Dependent Gene Transcription

1987 • 139 citations

The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription.

1988 • 127 citations

Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.

1987 • 100 citations

Transcriptional Regulation of Chorionic Gonadotropinα- andβ-Subunit Gene Expression by 8-Bromo-Adenosine 3′,5′-Monophosphate*

1986 • 83 citations

trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene.

1987 • 78 citations

Regulation of protein kinase C by cyclic adenosine 3':5'-monophosphate and a tumor promoter in skeletal myoblasts.

1987 • 40 citations

12-O-Tetradecanoyl Phorbol-13-Acetate Potentiates Adenosine 3′,5′-Monophosphate-Mediated Chorionic Gonadotropin Secretion by Cultured Human Choriocarcinoma Cells*

1987 • 33 citations