Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

Antibodies, a laboratory manual

1989 • 12,929 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Current protocols in molecular biology

1988 • 2,473 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

Developmental switch of CREM function during spermatogenesis: from antagonist to activator

1992 • 495 citations

Regulation of camp-inducible genes by creb

1990 • 416 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

1990 • 355 citations

Heterodimer formation between CREB and JUN proteins.

1990 • 347 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Structural determinants for transcriptional activation by cAMP-responsive DNA elements.

1988 • 258 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

1991 • 229 citations

Characterization of a bipartite activator domain in transcription factor CREB

1990 • 228 citations

Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

1990 • 226 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins.

1988 • 198 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-Dependent protein kinase

1991 • 192 citations

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

1992 • 189 citations

The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer.

1988 • 181 citations

Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene.

1988 • 169 citations

Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.

1984 • 155 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

1987 • 150 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

1990 • 133 citations

Co-expression of the Subunits of the Heterodimer of HIV-1 Reverse Transcriptase in Escherichia coli

1989 • 127 citations

Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein

1991 • 123 citations

Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.

1988 • 120 citations

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

1990 • 119 citations

Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells

1990 • 103 citations

In vivo monitoring of a cAMP-stimulated DNA-binding activity.

1990 • 93 citations

Forskolin inducibility and tissue-specific expression of the fibronectin promoter.

1989 • 91 citations

Tissue-Specific Enhancer of the Human Glycoprotein Hormone α-Subunit Gene: Dependence on Cyclic AMP-Inducible Elements

1987 • 71 citations

Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression.

1990 • 71 citations

Identification of Basal and Cyclic AMP Regulatory Elements in the Promoter of the Phosphoenolpyruvate Carboxykinase Gene

1988 • 61 citations

Characterization of Motifs Which Are Critical for Activity of the Cyclic AMP-Responsive Transcription Factor CREB

1991 • 57 citations

Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation.

1988 • 51 citations

Macromolecular interaction on a cAMP responsive region in the urokinase-type plasminogen activator gene: a role of protein phosphorylation

1990 • 37 citations

Purification and Characterization of a 43-kDa Transcription Factor Required for Rat Somatostatin Gene Expression

1989 • 31 citations

Forskolin Inducibility and Tissue-Specific Expression of the Fibronectin Promoter

1989 • 29 citations

A novel and rapid method to generate single stranded DNA probes for genomic footprinting

1988 • 23 citations