CREB represses transcription of fos promoter: role of phosphorylation.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

1988 • 391 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Proto-oncogene fos: Complex but versatile regulation

1987 • 296 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation.

1990 • 226 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

Modification of fos Proteins: Phosphorylation of c-fos, but Not v-fos, Is Stimulated by 12-Tetradecanoyl-Phorbol-13-Acetate and Serum

1987 • 180 citations

Identification of a Transcriptional Enhancer Element Upstream from the Proto-Oncogene fos

1985 • 171 citations

Inducible binding of a factor to the c-fos regulatory region.

1987 • 168 citations

Growth factor-induced gene expression: the ups and downs of c-fos regulation.

1990 • 88 citations

A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit Cα

1988 • 84 citations

Gene Regulation by Tyrosine Kinases: src Protein Activates Various Promoters, Including c-fos

1989 • 68 citations

Regulation of Proto-oncogene fos: A Paradigm for Early Response Genes

1988 • 47 citations