Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

The AIDS dementia complex: I. Clinical features

1986 • 1,679 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

The AIDS Dementia Complex

1988 • 1,387 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

APRIORITY

1961 • 1,293 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Biochemistry of metallothionein

1988 • 1,222 citations

Mossy fiber synaptic reorganization in the epileptic human temporal lobe

1989 • 1,150 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

1991 • 1,012 citations

The S100 family of EF-hand calcium-binding proteins: functions and pathology

1996 • 1,002 citations

Molecular architecture of basement membranes

1990 • 937 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

The physiological role of zinc as an antioxidant

1990 • 887 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Histochemical demonstration of heavy metals

1981 • 758 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Synaptic reorganization by mossy fibers in human epileptic fascia dentata

1991 • 666 citations

A critical physiological role of zinc in the structure and function of biomembranes

1981 • 635 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Transition Metals in Control of Gene Expression

1993 • 629 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

1992 • 575 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

MT-III, a brain-specific member of the metallothionein gene family.

1992 • 558 citations

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

1994 • 556 citations

The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation.

1996 • 544 citations

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease

1992 • 533 citations

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

1996 • 533 citations

A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain

1987 • 525 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

1993 • 490 citations

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+.

1985 • 489 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Histochemical detection of apoptosis in Parkinson's disease

1996 • 448 citations

ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

1996 • 447 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

The toxicity in vitro of β-amyloid protein

1995 • 427 citations

The mechanism of protein kinase C activation

1989 • 423 citations

Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model

1996 • 419 citations

Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study

1985 • 410 citations

Glutathione deficiency and human immunodeficiency virus infection

1992 • 409 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure

1967 • 393 citations

Zinc in Human Biology

1989 • 385 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat

1983 • 351 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.

1993 • 348 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats

1988 • 341 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

1995 • 334 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1994 • 329 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Neurotrophic protein S100 beta stimulates glial cell proliferation.

1991 • 326 citations

NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release

1995 • 319 citations

Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology

1991 • 313 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

The function of metallothionein

1995 • 299 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

Protection of Dentate Hilar Cells from Prolonged Stimulation by Intracellular Calcium Chelation

1989 • 292 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

Iron‐Melanin Interaction and Lipid Peroxidation: Implications for Parkinson's Disease

1991 • 285 citations

Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

1994 • 284 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

INACTIVATION OF OXIDATIVE AND PHOSPHORYLATIVE SYSTEMS IN MITOCHONDRIA BY PREINCUBATION WITH PHOSPHATE AND OTHER IONS

1955 • 277 citations

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia

1992 • 277 citations

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.

1989 • 275 citations

High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach

1990 • 268 citations

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

1991 • 268 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Disruption of the Metallothionein-III Gene in Mice: Analysis of Brain Zinc, Behavior, and Neuron Vulnerability to Metals, Aging, and Seizures

1997 • 248 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

Pyridinderivate als Komplexbildner. XI. Die Thermodynamik der Metallkomplexbildung mit Bis‐, Tris‐ und Tetrakis[(2‐pyridyl)methyl]‐aminen

1977 • 236 citations

Regional brain trace-element studies in Alzheimer's disease.

1988 • 231 citations

S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor

1990 • 230 citations

Contributory mechanisms in the causation of neurodegenerative disorders

1993 • 228 citations

Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.

1991 • 228 citations

Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels

1995 • 227 citations

Zinc-Containing Neurons

1994 • 224 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

A simplified timm stain procedure compatible with formaldehyde fixation and routine paraffin embedding of rat brain

1982 • 222 citations

Gene Encoding the β Subunit of S100 Protein Is on Chromosome 21: Implications for Down Syndrome

1988 • 222 citations

Selective release of endogenous zinc from the hippocampal mossy fibers in situ

1987 • 220 citations

Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice.

1996 • 219 citations

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

1993 • 216 citations

The NF-kappa B binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity

1989 • 215 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Zinc transfer from transcription factor IIIA fingers to thionein clusters.

1991 • 204 citations

Apoptotic Cell Death Induced by β‐Amyloid_1–42 Peptide Is Cell Type Dependent

1995 • 202 citations

S100 beta stimulates calcium fluxes in glial and neuronal cells.

1992 • 199 citations

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds

1993 • 198 citations

Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae

1989 • 197 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

1994 • 193 citations

Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.

1992 • 191 citations

Antioxidant status and lipid peroxidation in patients infected with HIV

1994 • 191 citations

Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.

1988 • 189 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

1995 • 188 citations

Basal expression of the inducible transcription factors c‐Jun, JunB, JunD, c‐Fos, FosB, and Krox‐24 in the adult rat brain

1995 • 187 citations

Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains

1990 • 186 citations

The role of inducible transcription factors in apoptotic nerve cell death

1995 • 184 citations

Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice.

1994 • 183 citations

Brief exposure to zinc is toxic to cortical neurons

1986 • 182 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

1993 • 180 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

Excitotoxic index — a biochemical marker of selective vulnerability

1991 • 178 citations

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.

1996 • 178 citations

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

1994 • 177 citations

The influence of zinc on apoptosis.

1995 • 176 citations

Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study

1988 • 175 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)

1994 • 170 citations

Zinc and Alzheimer's disease: is there a direct link?

1997 • 169 citations

Seizures in Rats Associated with Divalent Cation Inhibition of Na⁺–K⁺-ATP'ase

1971 • 167 citations

Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization

1990 • 165 citations

Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat

1992 • 163 citations

Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease

1993 • 163 citations

Expression and regulation of brain metallothionein

1995 • 162 citations

Zinc Ions Inhibit the Qp Center of Bovine Heart Mitochondrial bc1 Complex by Blocking a Protonatable Group

1995 • 161 citations

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

1995 • 160 citations

Human brain S100β and S100β mRNA expression increases with age: Pathogenic implications for Alzheimer's disease

1996 • 155 citations

Inhibition of the DNA‐binding activity of NF‐κB by gold compounds in vitro

1995 • 155 citations

Spontaneous and evoked release of endogenous Zn2+ in the hippocampal mossy fiber zone of the rat in situ

1985 • 154 citations

The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.

1989 • 151 citations

Intracellular free zinc and zinc buffering in human red blood cells

1991 • 151 citations

Glial Cytokines as Neuropathogenic Factors in HIV Infection

1994 • 147 citations

Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens.

1989 • 146 citations

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

1993 • 144 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

Ions binding to S100 proteins: structural changes induced by calcium and zinc on S100a and S100b proteins

1983 • 139 citations

Zinc transport in mammalian cells

1996 • 138 citations

Enrichment of glutamate in zinc-containing terminals of the cat visual cortex

1992 • 137 citations

Zinc Fingers

1993 • 137 citations

Inhibition of the respiratory chain by zinc ions

1967 • 135 citations

Chronic Zinc Deficiency Alters Neuronal Function of Hippocampal Mossy Fibers

1979 • 134 citations

A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

1992 • 132 citations

Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro

1996 • 131 citations

Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.

1995 • 129 citations

Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A

1994 • 129 citations

A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex.

1993 • 128 citations

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

1992 • 128 citations

Zinc ion-induced assembly of tubulin.

1977 • 126 citations

Timm's sulfide silver reaction for zinc during experimental anterograde degeneration of hippocampal mossy fibers

1971 • 125 citations

Overexpression of the Neurotrophic Cytokine S100β in Human Temporal Lobe Epilepsy

1995 • 125 citations

Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells

1995 • 125 citations

Hippocampal tin, aluminum and zinc in Alzheimer's disease

1993 • 125 citations

Zinc, human diseases and aging

1995 • 124 citations

Matrix Metalloproteinases in the Neocortex and Spinal Cord of Amyotrophic Lateral Sclerosis Patients

1996 • 123 citations

Poly(ADP‐ribose) polymerase is a zinc metalloenzyme

1984 • 120 citations

Neutron activation analysis techniques for identifying elemental status in Alzheimer's disease

1987 • 120 citations

Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?

1992 • 120 citations

Attenuated protein kinase C activity and translocation in Alzheimer's Disease brain

1994 • 118 citations

Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger

1996 • 116 citations

Aggregation and Metal‐Binding Properties of Mutant Forms of the Amyloid Aβ Peptide of Alzheimer's Disease

1996 • 116 citations

Immunocytochemistry of glutamate at the synaptic level.

1990 • 115 citations

Apoptosis associated DNA fragmentation in epileptic brain damage

1994 • 114 citations

Neurotrophic activity of S-100β in cultures of dorsal root ganglia from embryonic chick and fetal rat

1991 • 114 citations

Zn2+ potentiates ATP-activated currents in rat sympathetic neurons

1993 • 114 citations

Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite

1990 • 113 citations

Elemental imbalances in the olfactory pathway in Alzheimer's disease

1995 • 113 citations

Zn2+ permeates Ca2+permeable AMPA/kainate channels and triggers selective neural injury

1995 • 112 citations

Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc

1993 • 111 citations

Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage

1996 • 111 citations

Characterization of Neutral Proteinases from Alzheimer‐Affected and Control Brain Specimens: Identification of Calcium‐Dependent Metalloproteinases from the Hippocampus

1992 • 109 citations

Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways: A semiquantitative electron microscopic study in rats

1990 • 107 citations

Apoptosis Is Dependent on Intracellular Zinc and Independent of Intracellular Calcium in Lymphocytes

1994 • 104 citations

Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide

1986 • 104 citations

Characterisation of six additional human metallothionein genes

1994 • 104 citations

Inhibition of apoptosis by zinc: A reappraisal

1992 • 103 citations

Regulation of protein kinase C activity by cooperative interaction of Zn2+ and Ca2+.

1987 • 103 citations

Constitutive Expression of Metallothionein-III (MT-III), but Not MT-I, Inhibits Growth When Cells Become Zinc Deficient

1995 • 103 citations

The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic insulin-like growth factor I and growth hormone receptor genes.

1995 • 102 citations

Interaction of S-100 protein with cations and liposomes

1974 • 101 citations

Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease

1995 • 100 citations

Oxidative Processes and Antioxidants

1995 • 100 citations

Zinc ion binding to human brain calcium binding proteins. Calmodulin and S100b protein

1983 • 99 citations

Retroviral nucleocapsid protein-metal ion interactions: folding and sequence variants.

1990 • 98 citations

Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

1995 • 98 citations

Nerve Growth Factor in Different Crystal Forms Displays Structural Flexibility and Reveals Zinc Binding Sites

1994 • 97 citations

Zinc Binding to the HIV-1 Nucleocapsid Protein: A Thermodynamic Investigation by Fluorescence Spectroscopy

1996 • 97 citations

Role of the β-amyloid precursor protein in Alzheimer's disease

1994 • 95 citations

Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis

1996 • 94 citations

Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton

1990 • 92 citations

Comparative localization of enkephalin and cholecystokinin immunoreactivities and heavy metals in the hippocampus

1983 • 92 citations

Ca²⁺‐Dependent and Ca²⁺‐Independent Protein Kinase C Changes in the Brains of Patients with Alzheimer's Disease

1996 • 91 citations

Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)

1994 • 89 citations

Zinc‐Induced Seizures: A New Experimental Model of Epilepsy

1983 • 87 citations

Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

1979 • 87 citations

Oxidant-induced mobilization of zinc from metallothionein

1992 • 87 citations

The autometallographic zinc-sulphide method. A new approach involvingin vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles

1996 • 86 citations

An Introduction to the Biochemistry of Zinc

1989 • 85 citations

Properties of the Sp1 Zinc Finger 3 Peptide: Coordination Chemistry, Redox Reactions, and Metal Binding Competition with Metallothionein

1995 • 85 citations

A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors

1995 • 84 citations

Preferential induction of apoptosis in mouse CD4⁺CD8⁺αβTCR^IoCD3ε^Io thymocytes by zinc

1995 • 80 citations

Zinc-containing 7S-NGF complex. Evidence from zinc histochemistry for localization in salivary secretory granules.

1987 • 79 citations

The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.

1996 • 79 citations

Dose-dependent opposite effect of zinc on apoptosis in mouse thymocytes

1995 • 79 citations

Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion

1990 • 78 citations

Specificity and timing of the Zn2+ requirement for DNA synthesis by 3T3 cells

1989 • 78 citations

Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

1995 • 78 citations

Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells

1995 • 77 citations

Effects of heavy metal on rat liver microsomal Ca2(+)-ATPase and Ca2+ sequestering. Relation to SH groups.

1990 • 76 citations

Amyotrophic lateral sclerosis: the involvement of intracellular Ca2+ and protein kinase C

1996 • 76 citations

Studies on the reaction catalyzed by transport (Na, K) adenosine triphosphatase—I

1974 • 75 citations

An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease.

1995 • 74 citations

Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

1992 • 74 citations

Zinc Stimulates Mg²⁺-Dependent 3‘-Processing Activity of Human Immunodeficiency Virus Type 1 Integrase in Vitro

1996 • 72 citations

Kinetic lability of zinc bound to metallothionein in Ehrlich cells.

1988 • 71 citations

Zinc metabolism in normal and zinc-deficient rat brain

1984 • 71 citations

Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis

1992 • 70 citations

[43] Metallothioneins and other zinc-binding proteins in brain

1991 • 70 citations

Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation

1984 • 69 citations

Matrix metalloproteinase family.

1995 • 68 citations

Zinc deficiency causes apoptosis but not cell cycle alterations in organogenesis‐stage rat embryos: Effect of varying duration of deficiency

1995 • 68 citations

Response of olfactory Schwann cells to intranasal zinc sulfate irrigation

1995 • 68 citations

Molecular Machines that Control Genes

1995 • 68 citations

Kainate induces apoptosis in neurons

1996 • 67 citations

Purification and Characterization of the Recombinant Human Calcium-Binding S100 Proteins CAPL and CACY

1994 • 67 citations

α subunits influence Zn block of γ2 containing GABAA receptor currents

1995 • 66 citations

The Presence of Zinc‐Binding Proteins in Brain

1983 • 66 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse

1992 • 64 citations

Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat.

1996 • 63 citations

Tubulin-zinc interactions: binding and polymerizaton studies

1983 • 63 citations

Histochemical detection of zinc and copper in various neurons of the central nervous system

1981 • 63 citations

Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

1995 • 63 citations

Interleukin 1-induced depression of iron and zinc: role of granulocytes and lactoferrin

1987 • 62 citations

Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain

1994 • 62 citations

Tumor necrosis factor-alpha alters maternal and embryonic zinc metabolism and is developmentally toxic in mice.

1995 • 61 citations

Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion

1995 • 60 citations

A retrograde transport method for mapping zinc-containing fiber systems in the brain

1990 • 60 citations

Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures

1996 • 60 citations

Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase

1994 • 60 citations

Selective Increase in S‐100β Protein by Aging in Rat Cerebral Cortex

1990 • 58 citations

The neurotoxicity of zinc in the rat hippocampus

1990 • 57 citations

Bilateral reorganisation of mossy fibres in the rat hippocampus after a unilateral intracerebroventricular kainic acid injection

1993 • 57 citations

Metallothionein in Amyotrophic Lateral Sclerosis

1994 • 56 citations

Zinc reduces dentate granule cell hyperexcitability in epileptic humans

1995 • 55 citations

Calmodulin, zinc, and calcium in cellular and membrane regulation: An interpretive review

1980 • 55 citations

AMPA/Zn2+-induced neurotoxicity in rat primary cortical cultures: involvement of L-type calcium channels

1994 • 55 citations

Zinc modulation of drug binding, cocaine affinity states, and dopamine uptake on the dopamine uptake complex.

1993 • 54 citations

Calcyclin is a calcium and zinc binding protein

1990 • 54 citations

Zinc and Iron in Free Radical Pathology and Cellular Control

1989 • 53 citations

Zinc changes AMPA receptor properties: Results of binding studies and patch clamp recordings

1996 • 53 citations

Divalent transition-metal ions (Cu2+ and Zn2+) in the brains of epileptogenic and normal mice

1983 • 53 citations

Prevention of zinc neurotoxicity in vivo by N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN)

1996 • 52 citations

Effects of divalent metal ions on alveolar macrophage membrane adenosine triphosphatase activity.

1971 • 51 citations

Concentrations of zinc and iron in the brains of Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia.

1993 • 50 citations

The sodium-potassium ATPase inhibitor ouabain is neurotoxic in the rat substantia nigra and striatum

1995 • 49 citations

Calcyclin—Ca2+-binding protein homologous to glial S-100β is present in neurones

1993 • 49 citations

Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices

1993 • 47 citations

Laminin Interactions Important for Basement Membrane Assembly Are Promoted by Zinc and Implicate Laminin Zinc Finger-like Sequences

1996 • 47 citations

Zinc release from Xenopus transcription factor IIIA induced by chemical modifications

1989 • 46 citations

Degenerative and protective signaling mechanisms in the neurofibrillary pathology of AD

1995 • 46 citations

The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles

1991 • 46 citations

C-Fos Is Not Essential for Apoptosis

1996 • 45 citations

Properties of ATP-gated channels recorded from rat sympathetic neurons: voltage dependence and regulation by Zn2+ ions

1995 • 45 citations

Response : Zinc and Alzheimer's Disease

1995 • 45 citations

Zinc content in discrete hippocampal and amygdaloid areas of the epilepsy (El) mouse and normal mice

1988 • 45 citations

On the inhibition of mitochondrial electron transport by Zn²⁺ ions

1972 • 45 citations

Zinc-Binding Proteins in the Brain

1986 • 44 citations

Stable-isotope dilution measurement of zinc and lead in rat hippocampus and spinal cord

1982 • 44 citations

The βA4 Amyloid Precursor Protein Gene and Alzheimer's Disease

1996 • 43 citations

The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus

1987 • 43 citations

Zinc status in human immunodeficiency virus infection

1990 • 43 citations

Subunit-specific enhancement of glutamate receptor responses by zinc

1994 • 42 citations

Proconvulsant action of diethyldithiocarbamate in stimulation of the perforant path

1993 • 42 citations

Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain.

1992 • 42 citations

Abnormal tubulin aggregates induced by zinc sulfate in organotypic cultures of nerve tissue

1978 • 42 citations

Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction

1987 • 41 citations

The HIV-1 envelope protein GP120 induces neuronal apoptosis in hippocampal slices

1996 • 41 citations

Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat

1981 • 41 citations

Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions

1986 • 40 citations

Features of Seizures and Behavioral Changes Induced by Intrahippocampal Injection of Zinc Sulfate In the Rabbit: A New Experimental Model of Epilepsy

1986 • 40 citations

The effects of 6-hydroxydopamine and oxidative stress on the level of brain metallothionein

1993 • 39 citations

Two zinc‐dependent steps during G1 to S phase transition

1993 • 39 citations

The role of zinc in acquired immunodeficiency syndrome

1992 • 39 citations

Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

1994 • 37 citations

Glycine current in rat septal cholinergic neuron in culture: monophasic positive modulation by Zn2+

1996 • 37 citations

Retrograde tracing of zinc-containing neurons by selenide ions: a survey of seven selenium compounds.

1992 • 37 citations

Inhibition of NMDA-induced protein kinase C translocation by a Zn2+ chelator: Implication of intracellular Zn2+

1991 • 36 citations

Characterization of GABA current in rat septal cholinergic neurons in culture and its modulation by metal cations

1995 • 35 citations

Stimulation of DNA synthesis and 2‐deoxy‐D‐glucose transport in chick embryo cultures by excessive metal concentrations and by a carcinogenic hydrocarbon

1973 • 35 citations

Induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation

1996 • 34 citations

Lack of Ca2+ involvement in thymocyte apoptosis induced by chelation of intracellular Zn2+.

1995 • 34 citations

⁶⁵Zn Uptake from Blood into Brain in the Rat

1991 • 34 citations

Hypochlorous acid-induced mobilization of zinc from metalloproteins

1991 • 33 citations

Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid

1990 • 33 citations

Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain

1990 • 32 citations

The mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase. Thermodynamics and kinetics of activation

1976 • 31 citations

[Alzheimer's disease and the zinc theory].

1990 • 31 citations

Zinc and immune function.

1995 • 31 citations

Levels of hippocampal calcium and zinc following kindling-induced epilepsy

1985 • 30 citations

Effects of Subcutaneous Injections of Zinc Chloride on Seizures Induced by Noise and by Kainic Acid

1990 • 29 citations

Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases.

1990 • 29 citations

The distribution and binding of zinc in the hippocampus

1984 • 28 citations

Callosal neurones give rise to zinc-rich boutons in the rat visual cortex

1995 • 28 citations

The mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase. Activation by 2,2',2"-terpyridine and by 8-hydroxyquinoline-5-sulfonic acid

1976 • 28 citations

Enhancement by zinc of ATP-evoked dopamine release from rat pheochromocytoma PC12 cells

1995 • 27 citations

Increased Metallothionein in the Liver and Kidney of Patients With Amyotrophic Lateral Sclerosis

1992 • 27 citations

Hypochlorous acid mobilizes cellular zinc

1991 • 25 citations

The Man who would Hear Ocean Temperatures

1995 • 24 citations

Zinc Deficiency Decreases the Concentration of N-Methyl-D-Aspartate Receptors in Guinea Pig Cortical Synaptic Membranes

1995 • 24 citations

Transition metal chelator TPEN counteracts phorbol ester–induced actin cytoskeletal disruption in C6 rat glioma cells without inhibiting activation or translocation of protein kinase C

1994 • 24 citations

Neurobiology of Zinc

1989 • 24 citations

Effect of inhibiting NO synthesis on hippocampal extracellular glutamate concentration in seizures induced by kainic acid

1995 • 24 citations

Zinc-induced self-assembly of goat brain tubulin: Some novel aspects

1982 • 23 citations

Zinc modulates GABAB binding in rat brain

1992 • 23 citations

Opening the blood-brain barrier to zinc

1990 • 23 citations

Hippocampal Histopathology � A Critical Substrate for Dementia of the Alzheimer Type

2015 • 22 citations

Zinc-containing innervation of the subicular region in the rat

1995 • 22 citations

Subcortical pathology of Alzheimer's disease.

1990 • 22 citations

Zinc in Cell Division and Tissue Growth: Physiological Aspects

1989 • 21 citations

Appearance of neuronal S-100β during development of the rat brain

1996 • 20 citations

Zinc(II) ions selectively interact with DNA sequences present at the TFIIIA binding site of theXenopus5S-RNA gene

1995 • 18 citations

Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation

1995 • 18 citations

Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats

1995 • 17 citations

Amino Acid Composition, Immunoreactivity, Sequence Analysis, and Function of Bovine Hippocampal Metallothionein Isoforms

1996 • 17 citations

Psychopathology of senile dementia of the Alzheimer type.

1990 • 15 citations

Zinc enhances kainate neurotoxicity in the rat brain

1993 • 15 citations

Influence of ZnCl2 pretreatment on behavioral and histological responses to kainic acid in rats

1993 • 13 citations

Drastic reduction of the zinc‐ and magnesium‐stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus

1993 • 13 citations

Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus

1989 • 12 citations

SNAPs and SNAREs. Protein hooks help vesicles grab cell membranes.

1993 • 12 citations

ChemInform Abstract: PYRIDINE DERIVATIVES AS COMPLEXING AGENTS. XI. THERMODYNAMICS OF METAL COMPLEX FORMATION WITH BIS‐, TRIS‐ AND TETRAKIS((2‐PYRIDYL)METHYL)AMINES

1977 • 12 citations

Transduction signals induced in rat brain cortex astrocytes by the HIV‐1 gp120 glycoprotein

1996 • 12 citations

Changes of Protein Kinase C Subspecies in Staphylococcal Enterotoxin B-Induced Thymocyte Apoptosis

1995 • 11 citations

Systemic Interactions of Zinc

1989 • 11 citations

Chronic elevation of S100β protein does not alter APP mRNA expression or promote β-amyloid deposition in the brains of aging transgenic mice

1995 • 9 citations

Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease.

1990 • 9 citations

Evaluation of brain element composition in Alzheimer's disease using inductively-coupled plasma mass spectrometry

1994 • 9 citations

The Biological Significance of Zinc for Man: Problems and Prospects

1989 • 8 citations

Sensitivity of the binding sites on glutamate transporters to neurotoxic agents

1995 • 8 citations

431 Zinc promotes Aβ aggregation but attenuates Aβ neurotoxicity

1996 • 6 citations

The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain

1988 • 6 citations

Differential effects of zinc on hyperpolarizing and depolarizing GABAA synaptic potentials in hippocampal slice cultures

1995 • 6 citations

Modulation of a competitive N-methyl-d-aspartate receptor antagonist binding by zinc oxide

1997 • 6 citations

Abnormal homeostasis of pH and Zinc: The prelude for cerebral Aβ amyloid formation?

1996 • 3 citations