Poly(ADP-ribose) polymerase: a molecular nick-sensor

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.

1990 • 231 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

ADP-Ribose in DNA Repair: A New Component of DNA Excision Repair

1984 • 226 citations

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular.

1993 • 222 citations

Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.

1986 • 197 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1993 • 191 citations

A Shuttle Mechanism for DNA‐Protein Interactions

1982 • 184 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

1987 • 149 citations

Poly(ADP-ribosylation) of a DNA topoisomerase.

1983 • 145 citations

Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair

1992 • 135 citations

Modification of SV40 T antigen by poly ADP-ribosylation

1981 • 110 citations

Conformational Analysis of a 139 Base-pair DNA Fragment Containing a Single-stranded Break and Its Interaction with Human Poly(ADP-ribose) Polymerase

1994 • 109 citations

The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

1992 • 107 citations

Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.

1983 • 101 citations

Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells.

1990 • 100 citations

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

1990 • 85 citations

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.

1993 • 79 citations

Sequence and organization of the mouse poly (ADP-ribose) polymerase gene

1989 • 72 citations

Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association.

1993 • 69 citations

Influence of poly(ADP-ribose) polymerase on the enzymatic synthesis of SV40 DNA.

1991 • 64 citations

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

1993 • 64 citations

The interaction of Adenosine Diphosphoribosyl Transferase (ADPRT) with a cruciform DNA

1990 • 52 citations

Cell cycle perturbations following DNA damage in the presence of ADP-ribosylation inhibitors

1985 • 50 citations

Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair

1990 • 48 citations

Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions

1990 • 40 citations

Poly(ADP-ribose) polymerase forms loops with DNA

1987 • 39 citations

Chicken poly(ADP-ribose) synthetase: complete deduced amino acid sequence and comparison with mammalian enzyme sequences

1991 • 33 citations