Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1993 • 546 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 343 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

The 717Val→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

1991 • 131 citations

Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease

1992 • 16 citations