Zinc and Alzheimer's disease: is there a direct link?

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Human Memory and the Cholinergic System

1974 • 1,378 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Molecular architecture of basement membranes

1990 • 937 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.

1995 • 746 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

1991 • 689 citations

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 • 657 citations

A critical physiological role of zinc in the structure and function of biomembranes

1981 • 635 citations

Transition Metals in Control of Gene Expression

1993 • 629 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation.

1996 • 544 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)

1993 • 490 citations

Neural apoptosis

1995 • 464 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.

1996 • 447 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

The toxicity in vitro of β-amyloid protein

1995 • 427 citations

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

1994 • 413 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure

1967 • 393 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat

1983 • 351 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Translocation of zinc may contribute to seizure-induced death of neurons

1989 • 347 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1994 • 329 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat

1990 • 303 citations

A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease

1993 • 289 citations

Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels

1994 • 284 citations

AMPA receptor activation potentiates zinc neurotoxicity

1993 • 280 citations

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

1990 • 278 citations

INACTIVATION OF OXIDATIVE AND PHOSPHORYLATIVE SYSTEMS IN MITOCHONDRIA BY PREINCUBATION WITH PHOSPHATE AND OTHER IONS

1955 • 277 citations

Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.

1989 • 275 citations

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

1991 • 268 citations

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

1995 • 265 citations

Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes.

1994 • 256 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

Changes in brain gene expression shared by scrapie and Alzheimer disease.

1989 • 253 citations

Effect of calcium ion on S-100, a protein of the nervous system

1969 • 248 citations

Zinc neurotoxicity in cortical cell culture

1988 • 244 citations

The βA4 amyloid precursor protein binding to copper

1994 • 244 citations

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease

1993 • 234 citations

Increase in metallothionein produced by chemicals that induce oxidative stress

1991 • 232 citations

Regional brain trace-element studies in Alzheimer's disease.

1988 • 231 citations

Contributory mechanisms in the causation of neurodegenerative disorders

1993 • 228 citations

Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.

1991 • 228 citations

Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils

1992 • 227 citations

Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors

1994 • 223 citations

Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice.

1996 • 219 citations

Sulfated glycosaminoglycans: a common constituent of all amyloids?

1987 • 217 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan

1991 • 211 citations

Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease

1996 • 208 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Apoptotic Cell Death Induced by β‐Amyloid_1–42 Peptide Is Cell Type Dependent

1995 • 202 citations

Trafficking of cell-surface amyloid β-protein precursor: I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1996 • 197 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.

1992 • 191 citations

Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.

1988 • 189 citations

Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains

1990 • 186 citations

Proteins of the Brain Extracellular Fluid: Evidence for Release of S‐100 Protein

1984 • 185 citations

Brief exposure to zinc is toxic to cortical neurons

1986 • 182 citations

Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin

1994 • 177 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)

1994 • 170 citations

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

1993 • 168 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Seizures in Rats Associated with Divalent Cation Inhibition of Na⁺–K⁺-ATP'ase

1971 • 167 citations

Glutathione Efflux from Cultured Astrocytes

1996 • 165 citations

Reduced and oxidized glutathione in human and monkey brain

1987 • 164 citations

Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat

1992 • 163 citations

Zinc Ions Inhibit the Qp Center of Bovine Heart Mitochondrial bc1 Complex by Blocking a Protonatable Group

1995 • 161 citations

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

1995 • 160 citations

Inhibition of the DNA‐binding activity of NF‐κB by gold compounds in vitro

1995 • 155 citations

Biological half-lives of zinc and manganese in rat brain

1995 • 152 citations

The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus.

1989 • 151 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

ZINC IN MATURING RAT BRAIN: HIPPOCAMPAL CONCENTRATION AND LOCALIZATION¹

1972 • 150 citations

Zinc alters excitatory amino acid neurotoxicity on cortical neurons

1988 • 139 citations

Ions binding to S100 proteins: structural changes induced by calcium and zinc on S100a and S100b proteins

1983 • 139 citations

Enrichment of glutamate in zinc-containing terminals of the cat visual cortex

1992 • 137 citations

Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease

1996 • 137 citations

Trafficking of cell-surface amyloid β-protein precursor: II. Endocytosis, recycling, and lysosomal targeting detected by immunolocalization

1996 • 132 citations

Zinc‐Induced Aggregation of Human and Rat β‐Amyloid Peptides In Vitro

1996 • 131 citations

A POSSIBLE ROLE OF ZINC IN THE PATHOLOGY OF DEMENTIA

1981 • 129 citations

Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A

1994 • 129 citations

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

1992 • 128 citations

Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues

1995 • 125 citations

Hippocampal tin, aluminum and zinc in Alzheimer's disease

1993 • 125 citations

Zinc, human diseases and aging

1995 • 124 citations

Matrix Metalloproteinases in the Neocortex and Spinal Cord of Amyotrophic Lateral Sclerosis Patients

1996 • 123 citations

Cell death in the normal neonatal rat adrenal cortex

1973 • 121 citations

Cerebrospinal fluid trace element content in dementia

1983 • 120 citations

Neutron activation analysis techniques for identifying elemental status in Alzheimer's disease

1987 • 120 citations

Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia.

1995 • 119 citations

Attenuated protein kinase C activity and translocation in Alzheimer's Disease brain

1994 • 118 citations

Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger

1996 • 116 citations

Aggregation and Metal‐Binding Properties of Mutant Forms of the Amyloid Aβ Peptide of Alzheimer's Disease

1996 • 116 citations

Immunocytochemistry of glutamate at the synaptic level.

1990 • 115 citations

Mast cells in neuroimmune function: Neurotoxicological and neuropharmacological perspectives

1995 • 114 citations

Elemental imbalances in the olfactory pathway in Alzheimer's disease

1995 • 113 citations

Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite

1990 • 113 citations

Zn2+ permeates Ca2+permeable AMPA/kainate channels and triggers selective neural injury

1995 • 112 citations

Metalloproteinase-Dependent Neurite Outgrowth within a Synthetic Extracellular Matrix Is Induced by Nerve Growth Factor

1994 • 111 citations

Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats

1988 • 111 citations

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

1985 • 110 citations

Trk receptor alterations in Alzheimer's disease

1996 • 110 citations

Characterization of Neutral Proteinases from Alzheimer‐Affected and Control Brain Specimens: Identification of Calcium‐Dependent Metalloproteinases from the Hippocampus

1992 • 109 citations

Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways: A semiquantitative electron microscopic study in rats

1990 • 107 citations

Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets

1995 • 105 citations

Laminin and its neurite outgrowth‐promoting domain in the brain in Alzheimer's disease and Down's syndrome patients

1992 • 105 citations

Brain uptake of trace metals, zinc and manganese, in rats

1994 • 103 citations

Constitutive Expression of Metallothionein-III (MT-III), but Not MT-I, Inhibits Growth When Cells Become Zinc Deficient

1995 • 103 citations

Regulation of protein kinase C activity by cooperative interaction of Zn2+ and Ca2+.

1987 • 103 citations

Interaction of S-100 protein with cations and liposomes

1974 • 101 citations

Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease

1996 • 101 citations

Zinc ion binding to human brain calcium binding proteins. Calmodulin and S100b protein

1983 • 99 citations

Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

1995 • 98 citations

Nerve Growth Factor in Different Crystal Forms Displays Structural Flexibility and Reveals Zinc Binding Sites

1994 • 97 citations

Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton

1990 • 92 citations

Molecular dissection of the paired helical filament

1995 • 90 citations

Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)

1994 • 89 citations

Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease

1988 • 88 citations

Oxidant-induced mobilization of zinc from metallothionein

1992 • 87 citations

The autometallographic zinc-sulphide method. A new approach involvingin vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles

1996 • 86 citations

An Introduction to the Biochemistry of Zinc

1989 • 85 citations

Co-deposition of basement membrane components during the induction of murine splenic AA amyloid.

1991 • 84 citations

Soluble and membrane-bound S-100 protein in cerebral cortex synaptosomes

1975 • 84 citations

Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus

1991 • 82 citations

Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion

1990 • 78 citations

Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells

1995 • 77 citations

Studies on the reaction catalyzed by transport (Na, K) adenosine triphosphatase—I

1974 • 75 citations

An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease.

1995 • 74 citations

Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods

1992 • 74 citations

Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain

1994 • 72 citations

Growth-Inhibitory Factor, Metallothionein-Like Protein, and Neurodegenerative Diseases

1994 • 72 citations

Kinetic lability of zinc bound to metallothionein in Ehrlich cells.

1988 • 71 citations

Zinc metabolism in normal and zinc-deficient rat brain

1984 • 71 citations

[43] Metallothioneins and other zinc-binding proteins in brain

1991 • 70 citations

Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches

1996 • 70 citations

Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation

1984 • 69 citations

Response of olfactory Schwann cells to intranasal zinc sulfate irrigation

1995 • 68 citations

Matrix metalloproteinase family.

1995 • 68 citations

Involvement of free oxygen radicals in β-amyloidosis: An hypothesis

1994 • 67 citations

NGF mRNA is not decreased in frontal cortex from Alzheimer's Disease patients

1994 • 66 citations

The Presence of Zinc‐Binding Proteins in Brain

1983 • 66 citations

Zinc Uptake into Synaptosomes

1988 • 64 citations

Tubulin-zinc interactions: binding and polymerizaton studies

1983 • 63 citations

Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

1995 • 63 citations

Interaction between protein kinase C and regulatory ligand is enhanced by a chelatable pool of cellular zinc

1990 • 62 citations

Interleukin 1-induced depression of iron and zinc: role of granulocytes and lactoferrin

1987 • 62 citations

Tumor necrosis factor-alpha alters maternal and embryonic zinc metabolism and is developmentally toxic in mice.

1995 • 61 citations

Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion

1995 • 60 citations

Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase

1994 • 60 citations

Extracellular Zinc Ions Induces Mitogen-Activated Protein Kinase Activity and Protein Tyrosine Phosphorylation in Bombesin-Sensitive Swiss 3T3 Fibroblasts

1996 • 59 citations

Effects of dietary zinc on free radical generation, lipid peroxidation, and superoxide dismutase in trained mice

1991 • 59 citations

The neurotoxicity of zinc in the rat hippocampus

1990 • 57 citations

Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in down's syndrome and Alzheimer's Disease

1996 • 55 citations

AMPA/Zn2+-induced neurotoxicity in rat primary cortical cultures: involvement of L-type calcium channels

1994 • 55 citations

Nerve Growth Factor and Ras Regulate β‐Amyloid Precursor Protein Gene Expression in PC12 Cells

1996 • 53 citations

Hair and Serum Copper, Zinc, Calcium, and Magnesium Concentrations in Alzheimer‐type Dementia

1984 • 53 citations

Prevention of zinc neurotoxicity in vivo by N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN)

1996 • 52 citations

Effects of divalent metal ions on alveolar macrophage membrane adenosine triphosphatase activity.

1971 • 51 citations

Laminin Interactions Important for Basement Membrane Assembly Are Promoted by Zinc and Implicate Laminin Zinc Finger-like Sequences

1996 • 47 citations

Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematosus patients

1993 • 47 citations

Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability.

1996 • 46 citations

Degenerative and protective signaling mechanisms in the neurofibrillary pathology of AD

1995 • 46 citations

The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles

1991 • 46 citations

Response : Zinc and Alzheimer's Disease

1995 • 45 citations

Zinc-Binding Proteins in the Brain

1986 • 44 citations

Serum zinc, senile plaques, and neurofibrillary tangles

1995 • 43 citations

Abnormal tubulin aggregates induced by zinc sulfate in organotypic cultures of nerve tissue

1978 • 42 citations

Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction

1987 • 41 citations

Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat

1981 • 41 citations

Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions

1986 • 40 citations

The interactions of zinc, nickel, and cadmium with Xenopus transcription factor IIIA, assessed by equilibrium dialysis

1992 • 37 citations

Inhibition of NMDA-induced protein kinase C translocation by a Zn2+ chelator: Implication of intracellular Zn2+

1991 • 36 citations

Preferential expression of superoxide dismutase messenger RNA in melanized neurons in human mesencephalon

1993 • 35 citations

Induction of Metallothionein in Astrocytes by Cytokines and Heavy Metals

1994 • 35 citations

Stimulation of DNA synthesis and 2‐deoxy‐D‐glucose transport in chick embryo cultures by excessive metal concentrations and by a carcinogenic hydrocarbon

1973 • 35 citations

⁶⁵Zn Uptake from Blood into Brain in the Rat

1991 • 34 citations

Hypochlorous acid-induced mobilization of zinc from metalloproteins

1991 • 33 citations

The mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase. Thermodynamics and kinetics of activation

1976 • 31 citations

Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine

1996 • 31 citations

[Alzheimer's disease and the zinc theory].

1990 • 31 citations

Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases.

1990 • 29 citations

Role for zinc in a cellular response mediated by protein kinase C in human B lymphocytes

1991 • 29 citations

The mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase. Activation by 2,2',2"-terpyridine and by 8-hydroxyquinoline-5-sulfonic acid

1976 • 28 citations

Localization of copper-zinc superoxide dismutase mRNA in human hippocampus by in situ hybridization

1989 • 26 citations

Hypochlorous acid mobilizes cellular zinc

1991 • 25 citations

Indices of iron and copper status during experimentally induced, marginal zinc deficiency in humans

1992 • 25 citations

Glial Metallothionein

1994 • 24 citations

Localization of Metallothionein in the Mammalian Central Nervous System

1994 • 23 citations

Opening the blood-brain barrier to zinc

1990 • 23 citations

Hippocampal Histopathology � A Critical Substrate for Dementia of the Alzheimer Type

2015 • 22 citations

Subcortical pathology of Alzheimer's disease.

1990 • 22 citations

CSF zinc in Alzheimer's type dementia

1988 • 22 citations

Regulation of protein kinase C by Zn(2+)-dependent interaction with actin.

1991 • 20 citations

Zinc induces specific association of PKC with membrane cytoskeleton.

1990 • 18 citations

Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation

1995 • 18 citations

Copper and Zinc Levels in “Healthy” and “Sick” Elderly

1985 • 17 citations

Impaired peripheral zinc metabolism in patients with senile dementia of probable Alzheimer’s type as shown by low plasma concentrations of thymulin

1996 • 16 citations

Psychopathology of senile dementia of the Alzheimer type.

1990 • 15 citations

Drastic reduction of the zinc‐ and magnesium‐stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus

1993 • 13 citations

Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus

1989 • 12 citations

Changes of Protein Kinase C Subspecies in Staphylococcal Enterotoxin B-Induced Thymocyte Apoptosis

1995 • 11 citations

Systemic Interactions of Zinc

1989 • 11 citations

The Role of Zinc in Senile Dementia

1986 • 9 citations

Evaluation of brain element composition in Alzheimer's disease using inductively-coupled plasma mass spectrometry

1994 • 9 citations

Uptake and turnover of65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions

1987 • 9 citations

Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease.

1990 • 9 citations

Abnormal homeostasis of pH and Zinc: The prelude for cerebral Aβ amyloid formation?

1996 • 3 citations

522 Abnormal homeostasis of pH and zinc: The prelude for cerebral Aβ amyloid formation?

1996 • 1 citations