The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Easy calculations of lod scores and genetic risks on small computers.

1984 • 1,526 citations

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

1985 • 1,207 citations

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1986 • 1,033 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

1974 • 1,022 citations

Alzheimer's Disease

1986 • 772 citations

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

1985 • 715 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Localization of cystic fibrosis locus to human chromosome 7cen–q22

1985 • 498 citations

Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker

1985 • 488 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Report of the committee on the genetic constitution of the X and Y chromosomes

1985 • 369 citations

Use of cyclosporin a in establishing epstein-barr virus-transformed human lymphoblastoid cell lines

1984 • 355 citations

A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

1985 • 332 citations

Seizures and myoclonus in patients with Alzheimer's disease

1986 • 325 citations

Down's Syndrome and Alzheimer's disease: a review

1986 • 316 citations

Epidemiology of clinically diagnosed Alzheimer's disease

1986 • 285 citations

Alzheimer's disease: Genetic aspects and associated clinical disorders

1983 • 269 citations

The neuropathology of Alzheimer's disease: A review with pathogenetic, aetiological and therapeutic considerations

1985 • 199 citations

A Family With Histologically Confirmed Alzheimer's Disease

1983 • 176 citations

Familial Alzheimer's disease

1963 • 156 citations

Down's syndrome

1974 • 134 citations

DNA Markers for Nervous System Diseases

1984 • 132 citations

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin

1981 • 103 citations

Isolation of polymorphic DNA fragments from human chromosome 4

1987 • 100 citations

Partial trisomy 21

1977 • 99 citations

Cloned DNA probes regionally mapped to human Chromosome 21 and their use in determining the origin of nondisjunction

1985 • 93 citations

Report of the Committee on Human Gene Mapping by Recombinant DNA Techniques (Part 1 of 5)

1985 • 86 citations

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

1986 • 82 citations

Diagnostic criteria for primary neuronal degeneration of the Alzheimer's type.

1980 • 77 citations

Familial Down syndrome due to t(10;21) translocation: evidence that the Down phenotype is related to trisomy of a specific segment of chromosome 21.

1975 • 77 citations

Familial aggregation in Alzheimer dementia—I. A model for the age-dependent expression of an autosomal dominant gene

1986 • 75 citations

Presenile Alzheimer disease

1980 • 64 citations

[Alzheimer's presenile dementia transmitted in an extended kindred].

1985 • 63 citations

The genetics of alzheimer's disease: A review and a discussion of the implications

1986 • 60 citations

Familial aggregation in Alzheimer dementia—II. Clinical genetic implications of age-dependent onset

1986 • 39 citations

Isolation of polymorphic DNA segments from human chromosome 21

1985 • 38 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

Partial trisomies of chromosome 21 in man. Two new observations due to translocations 19;21 and 4;21

1977 • 37 citations

Abstracts of workshop presentations (Part 13 of 13)

1985 • 26 citations

Neurobiological Studies of Transmitter Systems in Aging and in Alzheimer‐Type Dementia^a

1985 • 17 citations

A linkage map of three anonymous human DNA fragments and SOD-1 on chromosome 21.

1985 • 12 citations

Abstracts of workshop presentations (Part 12 of 13)

1985 • 12 citations

Familial t (4;21)(q2.4;q2.2) leading to unbalanced offspring with partial duplication of 4q and of 21q without manifestations of the down syndrome

1984 • 12 citations

Down's Syndrome and Aging: Is Senile Dementia Inevitable?

1983 • 9 citations