Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria

1993 • 1,033 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis

1995 • 725 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

Rab9 functions in transport between late endosomes and the trans Golgi network.

1993 • 556 citations

Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids

1994 • 532 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Binding of acylated peptides and fatty acids to phospholipid vesicles: Pertinence to myristoylated proteins

1993 • 498 citations

Separation of Caveolae from Associated Microdomains of GPI-Anchored Proteins

1995 • 481 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Myristylation of picornavirus capsid protein VP4 and its structural significance

1987 • 475 citations

Lipid Modifications of Trimeric G Proteins

1995 • 468 citations

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae.

1994 • 449 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

GENETIC AND BIOCHEMICAL STUDIES OF PROTEIN N-MYRISTOYLATION

1994 • 403 citations

Inhibition of Adenylyl Cyclase by G _iα

1993 • 402 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

1990 • 389 citations

Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.

1989 • 383 citations

Purification and characterization of smooth muscle cell caveolae.

1994 • 347 citations

Protein Prenylation: a Mediator of Protein-Protein Interactions

1993 • 346 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase

1993 • 325 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1995 • 309 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state

1995 • 300 citations

Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes

1995 • 294 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

Protein N-myristoylation

1991 • 289 citations

Structure of the human ADP-ribosylation factor 1 complexed with GDP

1994 • 284 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Acylation of Proteins with Myristic Acid Occurs Cotranslationally

1987 • 274 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Fluorometric Evaluation of the Affinities of Isoprenylated Peptides for Lipid Bilayers

1994 • 253 citations

Arf proteins: the membrane traffic police?

1995 • 241 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Myristoylation and Differential Palmitoylation of the HCK Protein-Tyrosine Kinases Govern Their Attachment to Membranes and Association with Caveolae

1995 • 237 citations

Molecular cloning and expression of palmitoyl-protein thioesterase.

1994 • 229 citations

Lipid modification at the N terminus of photoreceptor G-protein α-subunit

1992 • 228 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

The NH2 terminus of retinal recoverin is acylated by a small family of fatty acids.

1992 • 215 citations

The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated.

1992 • 213 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization

1994 • 205 citations

Lipid domains in model and biological membranes

1994 • 199 citations

Two classes of fatty acid acylated proteins exist in eukaryotic cells.

1985 • 196 citations

Disruption of the Yeast N -Myristoyl Transferase Gene Causes Recessive Lethality

1989 • 190 citations

Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles.

1994 • 182 citations

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

1992 • 180 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

1994 • 179 citations

Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells.

1992 • 176 citations

G-protein Palmitoyltransferase Activity Is Enriched in Plasma Membranes

1996 • 170 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

A novel N-terminal motif for palmitoylation of G-protein α subunits

1993 • 156 citations

GPI-anchor biosynthesis

1995 • 154 citations

Membrane Binding of Myristylated Peptides Corresponding to the NH2 Terminus of Src

1994 • 154 citations

Biochemical Characterization of a Palmitoyl Acyltransferase Activity That Palmitoylates Myristoylated Proteins

1995 • 147 citations

Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

1994 • 141 citations

Inhibition of the receptor-mediated endocytosis of diferric transferrin is associated with the covalent modification of the transferrin receptor with palmitic acid.

1990 • 133 citations

In vitro synthesis of pp60v-src: myristylation in a cell-free system.

1988 • 118 citations

Covalent binding of arachidonate to G protein alpha subunits of human platelets.

1994 • 118 citations

Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43.

1992 • 112 citations

The src protein contains multiple domains for specific attachment to membranes.

1990 • 112 citations

p80/85 Cortactin Associates with the Src SH2 Domain and Colocalizes with v-Src in Transformed Cells

1995 • 112 citations

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.

1994 • 111 citations

Prenylation of Ras proteins is required for efficient hSOS1-promoted guanine nucleotide exchange.

1994 • 110 citations

Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification.

1994 • 107 citations

Unmyristylated Moloney murine leukemia virus Pr65gag is excluded from virus assembly and maturation events

1989 • 102 citations

Studies on the attachment of myristic and palmitic acid to cell proteins in human squamous carcinoma cell lines: evidence for two pathways.

1985 • 100 citations

Palmitoylation of Either Cys-3 or Cys-5 Is Required for the Biological Activity of the Lck Tyrosine Protein Kinase

1995 • 98 citations

The G protein .alpha.s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification

1993 • 97 citations

Fatty Acylation of α2

1995 • 90 citations

Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension

1994 • 82 citations

The Myristoyl Moiety of Myristoylated Alanine-rich C Kinase Substrate (MARCKS) and MARCKS-related Protein Is Embedded in the Membrane

1995 • 80 citations

Interaction of tyrosine kinase oncoproteins with cellular membranes

1993 • 77 citations

Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication.

1992 • 76 citations

Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor.

1993 • 73 citations

Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase.

1993 • 71 citations

Characterization of an acyltransferase acting on p21N-ras protein in a cell-free system

1991 • 69 citations

Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate.

1990 • 68 citations

Identification of a Novel Fatty Acylated Protein That Partitions between the Plasma Membrane and Cytosol and Is Deacylated in Response to Serum and Growth Factor Stimulation

1989 • 68 citations

Fluorescence Studies of the Location and Membrane Accessibility of the Palmitoylation Sites of Rhodopsin

1994 • 64 citations

The α‐subunits of G‐proteins G₁₂ and G₁₃ are palmitoylated, but not amidically myristoylated

1994 • 63 citations

P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage

1993 • 59 citations

Demyristoylation of the major substrate of protein kinase C (MARCKS) by the cytoplasmic fraction of brain synaptosomes.

1994 • 57 citations

Failure to myristoylate the alpha subunit of Gz is correlated with an inhibition of palmitoylation and membrane attachment, but has no affect on phosphorylation by protein kinase C.

1994 • 56 citations

Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein.

1992 • 50 citations

Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae.

1992 • 50 citations

N-terminal fatty acylation of the α-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation

1994 • 49 citations

Fatty acyl transfer by human N-myristyl transferase is dependent upon conserved cysteine and histidine residues.

1994 • 48 citations

Acylation of endogenous myelin proteolipid protein with different acyl-CoAs.

1987 • 48 citations

Amino-Terminal Palmitate or Polybasic Domain Can Provide Required Second Signal to Myristate for Membrane Binding of P56lck

1995 • 47 citations

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization.

1994 • 46 citations

Microsomal membranes contain a high affinity binding site for prenylated peptides

1993 • 42 citations

Purification of protein fatty acyltransferase and determination of its distribution and topology.

1990 • 41 citations

The role of palmitoylation of the guanine nucleotide binding protein G11α in defining interaction with the plasma membrane

1995 • 40 citations

Determination of the Structural Requirements for Palmitoylation of p63

1995 • 39 citations

Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function

1995 • 37 citations

Role of Heterogeneous N-terminal Acylation of Recoverin in Rhodopsin Phosphorylation

1995 • 36 citations

A rapid posttranslational myristylation of a 68-kD protein in D. discoideum.

1990 • 35 citations

Acylation of viral glycoproteins: structural requirements for palmitoylation of transmembrane proteins

1995 • 30 citations

The ADP/ATP Carrier is the 32-Kilodalton Receptor for an NH₂-Terminally Myristylated Src Peptide but Not for pp60^src Polypeptide

1993 • 28 citations

Fatty Acylation of the Rat Asialoglycoprotein Receptor

1995 • 24 citations

Hydrophobie modifications of membrane proteins by palmitoylation in vitro

1989 • 23 citations

The ADP/ATP carrier is the 32-kilodalton receptor for an NH2-terminally myristylated src peptide but not for pp60src polypeptide.

1993 • 17 citations

[19] Identification of N-terminal myristyl blocking groups in proteins

1984 • 13 citations

Characterization and cellular localization of human myristoyl-CoA: protein N-myristoyltransferase

1995 • 8 citations

[11] Effects of prenyl modifications on interactions of small G proteins with regulators

1995 • 8 citations