Palmitoylation of Either Cys-3 or Cys-5 Is Required for the Biological Activity of the Lck Tyrosine Protein Kinase

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae.

1994 • 449 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae.

1994 • 389 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.

1989 • 349 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

The covalent modification of eukaryotic proteins with lipid.

1987 • 319 citations

Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.

1995 • 318 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization

1994 • 205 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

1994 • 179 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.

1992 • 175 citations

VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.

1994 • 166 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

Cloned lines of natural killer cells

1980 • 127 citations

Functional dissection of the lck proximal promoter.

1992 • 120 citations

Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43.

1992 • 112 citations

Analysis of the activity and phosphorylation of the lck protein in lymphoid cells.

1989 • 68 citations

Depalmitylation with hydroxylamine alters the functional properties of rhodopsin.

1991 • 61 citations

Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.

1992 • 58 citations

Functional Dissection of the lck Proximal Promoter

1992 • 51 citations

Amino-Terminal Palmitate or Polybasic Domain Can Provide Required Second Signal to Myristate for Membrane Binding of P56lck

1995 • 47 citations

Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta.

1994 • 39 citations