Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Posttranslational modification of proteins by isoprenoids in mammalian cells

1990 • 515 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1990 • 465 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.

1991 • 391 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

Human Lamin B Contains a Farnesylated Cysteine Residue

1989 • 324 citations

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

1986 • 285 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Identification of Geranylgeranyl-Modified Proteins in HeLa Cells

1990 • 217 citations

The gamma subunit of transducin is farnesylated.

1990 • 187 citations

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

1991 • 177 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1991 • 164 citations

Enzymatic modification of proteins with a geranylgeranyl isoprenoid.

1991 • 164 citations

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.

1989 • 162 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.

1991 • 148 citations

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

1991 • 126 citations

Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

1990 • 125 citations

Molecular cloning and characterization of the chicken gene homologous to the transforming gene of rous sarcoma virus

1981 • 121 citations

Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.

1991 • 116 citations

Identification of Small Clusters of Divergent Amino Acids that Mediate the Opposing Effects of ras and K rev -1

1990 • 114 citations

The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.

1991 • 109 citations

rasH mutants deficient in GTP binding.

1986 • 107 citations

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

1989 • 106 citations

rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif

1991 • 102 citations

The residues of Ras and Rap proteins that determine their GAP specificities

1991 • 100 citations

Ras p21: effects and regulation

1991 • 78 citations

The ras/cholesterol connection: implications for ras oncogenicity.

1992 • 78 citations

Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins.

1990 • 62 citations

Identification of amino acid residues required for Ras p21 target activation.

1991 • 53 citations

Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae.

1989 • 51 citations

High-level expression of c-H-ras1 fails to fully transform rat-1 cells.

1988 • 46 citations

Biological activity of synthetic analogs of tremerogen A-10

1980 • 41 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations

A role for isoprenoid lipids in the localization and function of an oncoprotein.

1990 • 37 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins

1992 • 30 citations

Prenylated proteins: synthesis of geranylgeranylcysteine and identification of this thioether amino acid as a component of proteins in CHO cells.

1990 • 24 citations

Alternate mechanisms of ras activation are complementary and favor and formation of ras-GTP.

1992 • 22 citations