Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

Palmitoylation of the human β2-adrenergic receptor

1989 • 599 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras.

1993 • 344 citations

Lipid modifications of G proteins: alpha subunits are palmitoylated.

1993 • 336 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

1992 • 196 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells.

1992 • 176 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Human serotonin1B receptor expression in Sf9 cells: Phosphorylation, palmitoylation, and adenylyl cyclase inhibition

1993 • 146 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.

1993 • 128 citations

Covalent binding of arachidonate to G protein alpha subunits of human platelets.

1994 • 118 citations

Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43.

1992 • 112 citations

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

1994 • 99 citations

Analysis of the palmitoylation and membrane targeting domain of neuromodulin (GAP-43) by site-specific mutagenesis

1993 • 71 citations

Depalmitylation with hydroxylamine alters the functional properties of rhodopsin.

1991 • 61 citations

Identification of additional members of human G-protein-coupled receptor kinase multigene family.

1993 • 55 citations