Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Small GTP-Binding Proteins

1992 • 526 citations

Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosa

1991 • 460 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

A three-base-pair deletion in the peripherin–RDS gene in one form of retinitis pigmentosa

1991 • 381 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

1992 • 323 citations

Cloning of a gene that is rearranged in patients with choroideraemia

1990 • 318 citations

Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product

1992 • 296 citations

GTP-binding proteins in intracellular transport

1992 • 277 citations

Steady-state kinetic mechanism of ras farnesyl:protein transferase

1992 • 242 citations

Retinitis Pigmentosa

1987 • 236 citations

Localization of Usher syndrome type II to chromosome 1q

1990 • 217 citations

On the Molecular Genetics of Retinitis Pigmentosa

1992 • 189 citations

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

1991 • 177 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein.

1990 • 161 citations

Mapping recessive ophthalmic diseases: Linkage of the locus for Usher syndrome type II to a DNA marker on chromosome 1q

1990 • 137 citations

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

1992 • 136 citations

Dependence of Ypt1 and Sec4 membrane attachment on Bet2

1991 • 118 citations

Biochemistry of the Eye

1991 • 108 citations

Isolation of a candidate gene for choroideremia.

1992 • 71 citations

An autosomal homologue of the choroideremia gene colocalizes with the usher syndrome type II locus on the distal part of chromosome 1q

1992 • 70 citations

Cannibalism in the Neolithic

1991 • 6 citations