N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

Rab GTPases in vesicular transport

1993 • 379 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Dynamic fatty acylation of p21N-ras.

1987 • 309 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.

1992 • 180 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

1993 • 139 citations

Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses

1984 • 107 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Plasma Membrane-Targeted ras GTPase-Activating Protein Is a Potent Suppressor of p21^ras Function

1993 • 67 citations

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

1988 • 39 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins

1992 • 30 citations