Neuronal degeneration in human diseases and animal models

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1991 • 2,763 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury

1971 • 1,112 citations

Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily

1989 • 1,086 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

1983 • 811 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Neurofilament gene expression: a major determinant of axonal caliber.

1987 • 705 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

Perforant pathway changes and the memory impairment of Alzheimer's disease

1986 • 665 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

1982 • 541 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Nicotinic acetylcholine binding sites in Alzheimer's disease

1986 • 485 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

1987 • 472 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

Memory‐related neural systems in Alzheimer's disease

1990 • 450 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Cell loss in the locus coeruleus in senile dementia of Alzheimer type

1981 • 443 citations

Control of axonal caliber by neurofilament transport.

1984 • 439 citations

Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

1980 • 434 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

The neuropathology of aminergic nuclei in Alzheimer's disease

1988 • 419 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q

1990 • 394 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

1991 • 373 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Slow Axonal Transport of Neurofilament Proteins: Impairment of β,β′-Iminodipropionitrile Administration

1978 • 340 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

Pathology of the Nervous System.

1972 • 322 citations

Alzheimer's disease affects limbic nuclei of the thalamus

1991 • 316 citations

Transgenic mice susceptible to poliovirus.

1991 • 293 citations

Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.

1991 • 288 citations

Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

1991 • 280 citations

Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

1990 • 278 citations

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

1990 • 278 citations

Evidence for task-dependent memory dysfunction in the aged monkey

1989 • 269 citations

Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease

1981 • 266 citations

NGF improves spatial memory in aged rodents as a function of age

1991 • 263 citations

Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction

1991 • 258 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

1986 • 251 citations

Cholinergic Innervation in Neuritic Plaques

1982 • 249 citations

Relation of Neuronal APP-751/APP-695 mRNA Ratio and Neuritic Plaque Density in Alzheimer's Disease

1990 • 248 citations

Reduced Numbers of Somatostatin Receptors in the Cerebral Cortex in Alzheimer's Disease

1985 • 248 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease

1982 • 239 citations

Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center

1988 • 238 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

1991 • 234 citations

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

1988 • 233 citations

Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers.

1985 • 228 citations

Nucleus Raphe Dorsalis in Dementia of the Alzheimer Type

1984 • 220 citations

Neuropeptides in Alzheimer type dementia

1983 • 214 citations

Progress in Neuropathology

1972 • 203 citations

Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons

1989 • 197 citations

Glutamate dysfunction and selective motor neuron degeneration inamyotrophic lateral sclerosis: A hypothesis

1990 • 193 citations

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1991 • 190 citations

THE AXONAL PATHOLOGY IN CHRONIC IDPN INTOXICATION

1980 • 185 citations

Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells.

1991 • 178 citations

Alzheimer‐related neuronal protein A68: Specificity and distribution

1987 • 176 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

1990 • 170 citations

Neurofibrillary axonal swellings and amyotrophic lateral sclerosis

1984 • 164 citations

Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

1991 • 161 citations

Phosphorylated Neurofilament Antigens in Neurofibrillary Tangles in Alzheimerʼs Disease

1986 • 158 citations

Age differences in recognition memory of the rhesus monkey (Macaca mulatta)

1987 • 157 citations

Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects

1991 • 148 citations

Region-specific loss of glutamate innervation in Alzheimer's disease

1987 • 147 citations

Pathology of motor neurons in accelerated hereditary canine spinal muscular atrophy.

1982 • 144 citations

Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage

1991 • 142 citations

Clinical Neurology of Aging

1985 • 141 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

Amyloid precursor protein in aged nonhuman primates.

1991 • 141 citations

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

1991 • 140 citations

Evidence for Cholinergic Neurites in Senile Plaques

1984 • 140 citations

Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton

1991 • 138 citations

THE RESPONSE OF VENTRAL HORN NEURONS TO AXONAL TRANSECTION

1972 • 133 citations

A special type of senile plaque, possibly an initial stage

1987 • 129 citations

Slowing of the axonal transport of neurofilament proteins during development

1983 • 127 citations

Handbook of Amyotrophic Lateral Sclerosis

1992 • 126 citations

Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates

1990 • 121 citations

Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons

1991 • 118 citations

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

1991 • 116 citations

Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration

1981 • 114 citations

Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.

1990 • 114 citations

RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein

1991 • 104 citations

Fast axonal transport in motor nerve regeneration

1976 • 101 citations

Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

1991 • 98 citations

Hirano bodies contain tau protein

1987 • 95 citations

Autosomal Dominance in a Late-Onset Motor Neuron Disease in the Mouse

1986 • 92 citations

Tau gene expression in rat sensory neurons during development and regeneration

1991 • 89 citations

HEREDITARY CANINE SPINAL MUSCULAR ATROPHY

1979 • 89 citations

The Pathogenesis of Reactive Axonal Swellings: Role of Axonal Transport

1977 • 85 citations

Neuropeptidergic Systems in Plaques of Alzheimerʼs Disease

1987 • 84 citations

Alterations in levels of mRNAs coding for neurofilament protein subunits during regeneration

1990 • 81 citations

Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates

1985 • 81 citations

International review of neurobiology

1969 • 81 citations

Loss of GABAergic neurons in medial septum after fimbria-fornix transection

1987 • 80 citations

Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons

1990 • 78 citations

Cytoskeletal disorganization induced by local application of β,β′‐iminodipropionitrile and 2,5‐hexanedione

1983 • 77 citations

Glutamate‐, glutaminase‐, and taurine‐immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease

1991 • 75 citations

The topographic distribution of brain atrophy in Alzheimer's disease

1991 • 72 citations

α1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits

1989 • 70 citations

Aberrant phosphorylation of neurofilaments accompanies transmitter-related changes in rat septal neurons following transection of the fimbria-fornix

1989 • 69 citations

Activation to acquisition : functional aspects of the basal forebrain cholinergic system

1991 • 69 citations

Alternative splicing of the βA4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients

1991 • 69 citations

Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse

1987 • 68 citations

Multiple Transmitter Systems Contribute Neurites to Individual Senile Plaques

1988 • 67 citations

Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus.

1989 • 67 citations

Heterogeneous expression of poliovirus receptor-related proteins in human cells and tissues.

1990 • 65 citations

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

1985 • 65 citations

Linkage analysis in familial amyotrophic lateral sclerosis

1989 • 63 citations

Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS)

1992 • 62 citations

Animal models of amyotrophic lateral sclerosis and the spinal muscular atrophies

1989 • 59 citations

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

1986 • 58 citations

Neurofilamentous Abnormalities in Motor Neurons in Spontaneously Occurring Animal Disorders

1988 • 58 citations

Sequestration of Tubulin in Neurons in Alzheimer's disease

1986 • 53 citations

Basal forebrain neurons provide major cholinergic innervation of primate neocortex

1986 • 53 citations

The possible role of adhesion in synaptic modification

1991 • 52 citations

Regional heterogeneity of choline acetyltransferase activity in primate neocortex

1984 • 51 citations

Neurofilament Distribution is Altered in the Mnd (Motor Neuron Degeneration) Mouse

1991 • 45 citations

Acetylcholinesterase activity in senile plaques of aged macaques

1984 • 45 citations

Neurotransmitters in neocortex of aged rhesus monkeys

1991 • 43 citations

Autosomal dominant inheritance of hereditary canine spinal muscular atrophy

1984 • 43 citations

Levels of neurotransmitter and cytoskeletal protein mRNAs during nerve regeneration in sympathetic ganglia

1988 • 41 citations

Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse

1987 • 41 citations

Molecular Approaches to Hereditary Diseases of the Nervous System: Huntington's Disease as a Paradigm

1991 • 40 citations

Hereditary spinal muscular atrophy in Brittany Spaniels: clinical manifestations.

1979 • 36 citations

Processing of the Alzheimer's Disease ΒZA4 Amyloid Protein Precursor (APP)

1991 • 36 citations

A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord

1991 • 35 citations

Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain

1991 • 34 citations

Ubiquitin deposits are present in spinal motor neurons in all stages of the disease in the motor neuron degeneration (Mnd) mutant of the mouse

1991 • 31 citations

Molecular pathology of Alzheimer amyloid and neurofibrillary tangles

1990 • 27 citations

AXONAL TRANSPORT IN HEREDITARY CANINE SPINAL MUSCULAR ATROPHY (HCSMA)

1982 • 21 citations

Excitotoxicity and Neuropsychiatric Disorders

1991 • 21 citations

Changes in size of motor axons in hereditary canine spinal muscular atrophy.

1989 • 20 citations

THE TRANSPORT OF ACTIN AND TUBULIN AND THE RATE OF AXONAL REGENERATION

1982 • 18 citations

Changes in neuronal size and neurotransmitter marker in hereditary canine spinal muscular atrophy.

1989 • 15 citations

Serotoninergic neurites in senile plaques in cingulate cortex of aged nonhuman primate

1989 • 10 citations