Ubiquitin deposits are present in spinal motor neurons in all stages of the disease in the motor neuron degeneration (Mnd) mutant of the mouse

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

1988 • 541 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Cell Surface Molecule Associated with Lymphocyte Homing Is a Ubiquitinated Branched-Chain Glycoprotein

1986 • 312 citations

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.

1982 • 293 citations

Ubiquitin deposits in anterior horn cells in motor neurone disease

1988 • 277 citations

A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin

1988 • 226 citations

Activation of polyubiquitin gene expression during developmentally programmed cell death

1990 • 214 citations

Arthrin, a myofibrillar protein of insect flight muscle, is an actin-ubiquitin conjugate

1987 • 210 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

1989 • 195 citations

Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin Is the Reactive Species

1986 • 163 citations

Ubiquitin-protein conjugates in Alzheimer's lesions

1987 • 97 citations

Autosomal Dominance in a Late-Onset Motor Neuron Disease in the Mouse

1986 • 92 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse

1987 • 68 citations

Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions.

1987 • 64 citations

A Study of Infantile Motor Neuron Disease with Neurofilament and Ubiquitin Immunocytochemistry*

1989 • 62 citations

Inclusion bodies in motor cortex and brainstem of patients with motor neurone disease are detected by immunocytochemical localisation of ubiquitin

1989 • 61 citations

Neurofilament Distribution is Altered in the Mnd (Motor Neuron Degeneration) Mouse

1991 • 45 citations

Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse

1987 • 41 citations

Ubiquitin gene expression in brain and spinal cord in motor neurone disease

1989 • 25 citations

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