Neurotransmitters in neocortex of aged rhesus monkeys

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Fluorometric assay of proteins in the nanogram range

1973 • 1,640 citations

APRIORITY

1961 • 1,293 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

Neocortical cell counts in normal human adult aging

1987 • 676 citations

Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex

1987 • 577 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

α ₂ -Adrenergic Mechanisms in Prefrontal Cortex Associated with Cognitive Decline in Aged Nonhuman Primates

1985 • 544 citations

The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory

1991 • 525 citations

Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain

1984 • 454 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys

1981 • 352 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type

1981 • 274 citations

Evidence for task-dependent memory dysfunction in the aged monkey

1989 • 269 citations

AGEING, MONOAMINES, AND MONOAMINE-OXIDASE LEVELS

1972 • 263 citations

Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction

1991 • 258 citations

Cholinergic Innervation in Neuritic Plaques

1982 • 249 citations

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

1991 • 234 citations

Brain Acetylcholine Synthesis Declines with Senescence

1981 • 230 citations

Age-related behavioral and neurobiological changes: A review with an emphasis on memory

1981 • 222 citations

Age-related changes in multiple neurotransmitter systems in the monkey brain

1989 • 222 citations

Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to <scp>l</scp>‐Kynurenine

1989 • 221 citations

Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes

1981 • 211 citations

Co-localization of GABA and neuropeptides in neocortical neurons

1986 • 206 citations

The nucleus basalis of Meynert in neurological disease: A quantitative morphological study

1985 • 191 citations

Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis

1988 • 186 citations

Senile plaques in cortex of aged normal monkeys

1985 • 186 citations

Aging in the Rhesus Monkey: Effects on Visual Discrimination Learning and Reversal Learning

1979 • 181 citations

Effects of aging on visual recognition memory in the rhesus monkey

1988 • 180 citations

Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat

1988 • 171 citations

Memory Deficits in Aged Cebus Monkeys and Facilitation With Central Cholinomimetics

1980 • 170 citations

Immunohistochemical study of glutaminase‐containing neurons in the cerebral cortex and thalamus of the rat

1988 • 162 citations

Age differences in recognition memory of the rhesus monkey (Macaca mulatta)

1987 • 157 citations

Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease

1986 • 155 citations

Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids

1989 • 154 citations

Biochemical Evidence of Selective Nerve Cell Changes in the Normal Ageing Human and Rat Brain

1983 • 145 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 142 citations

Cortical Substance P‐Like Immunoreactivity in Cases of Alzheimer's Disease and Senile Dementia of the Alzheimer Type

1982 • 141 citations

Aging and behavior: A comprehensive integration of research findings

1978 • 140 citations

Evidence for Cholinergic Neurites in Senile Plaques

1984 • 140 citations

Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection

1990 • 126 citations

The neural basis of memory decline in aged monkeys

1988 • 121 citations

Neurotransmitters and memory: Role of cholinergic, serotonergic, and noradrenergic systems.

1987 • 118 citations

Localization of glutaminase-like and aspartate aminotransferase-like immunoreactivity in neurons of cerebral neocortex

1985 • 115 citations

Aging is associated with a diffuse impairment of forebrain cholinergic neurons

1990 • 114 citations

Kynurenic acid is present in the rat brain and its content increases during development and aging processes

1988 • 113 citations

Transplantation of norepinephrine neurons into aged rats improves performance of a learned task

1988 • 111 citations

Acetylcholine release from rat cortical slices during postnatal development and aging

1983 • 109 citations

Widespread reduction of somatostatin‐like immunoreactivity in the cerebral cortex in Alzheimer's disease

1986 • 102 citations

Localization of cellular changes within multimodal sensory regions in aged monkey brain: Possible implications for age-related cognitive loss☆

1980 • 99 citations

REGIONAL DISTRIBUTION OF MONOAMINES AND THEIR METABOLITES IN THE HUMAN BRAIN

1978 • 99 citations

Effects of aging on the neurons within area 17 of rhesus monkey cerebral cortex

1989 • 99 citations

Noradrenergic changes and memory loss in aged mice

1985 • 97 citations

Senile plaques in aged squirrel monkeys

1987 • 93 citations

Age Changes in the Human for Some Enzymes Associated with Metabolism of Catecholamines, GABA and Acetylcholine

1975 • 90 citations

Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys

1990 • 89 citations

Substance P‐like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

1987 • 86 citations

Behavioral alterations in patients with basal ganglia lesions.

1976 • 83 citations

Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates

1985 • 81 citations

Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection

1987 • 79 citations

Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease

1990 • 74 citations

Multiple Transmitter Systems Contribute Neurites to Individual Senile Plaques

1988 • 67 citations

A survey of substance P, somatostatin, and neurotensin levels in aging in the rat and human central nervous system

1981 • 67 citations

Temporal patterns of somatostatin immunoreactivity in the cerebrospinal fluid of the rhesus monkey: effect of environmental lighting

1982 • 65 citations

Endogenous glutamate release from frontal cortex of adult and aged rats

1989 • 59 citations

Somatostatinergic neurites in senile plaques of aged non-human primates

1984 • 57 citations

The basal nucleus of Meynert revised: the nerve cell number decreases with age

1989 • 56 citations

Adrenergic receptors in aging and Alzheimer's disease: Decreased α2-receptors demonstrated by [3H]p-aminoclonidine binding in prefrontal cortex

1991 • 56 citations

The cytoarchitectonic distribution of senile plaques in three aged monkeys

1990 • 53 citations

Serotonin concentrations in normal aging human brains: Relation to serotonin receptors

1984 • 46 citations

Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey

1990 • 43 citations

Aging and behavior. A comprehensive integration of research findings

1985 • 40 citations

Neuron numbers and dendritic extent in normal aging and alzheimer's disease

1987 • 32 citations

Relative Quantitation of Monoamine Histofluorescence in Young and Old Non-Human Primates

1978 • 22 citations

Serotoninergic neurites in senile plaques in cingulate cortex of aged nonhuman primate

1989 • 10 citations

Deleted Work

1955 • 0 citations