A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Apoptotic Pathways

1998 • 1,193 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

Mitochondria and cell death

1999 • 763 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

Lysosomal Protease Pathways to Apoptosis

2001 • 650 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

1996 • 596 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

2000 • 361 citations

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

1996 • 325 citations

Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

2000 • 321 citations

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

2000 • 306 citations

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH

1999 • 247 citations

Analysis of the membrane potential of rat‐ and mouse‐liver mitochondria by flow cytometry and possible applications

1990 • 241 citations

Bid-induced Cytochrome c Release Is Mediated by a Pathway Independent of Mitochondrial Permeability Transition Pore and Bax

2000 • 179 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability

1998 • 177 citations

Investigation of bax‐induced release of cytochrome c from yeast mitochondria

1999 • 131 citations

Mutations of the bak gene in human gastric and colorectal cancers.

2000 • 124 citations

Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes

2000 • 109 citations

Bax accelerates tumorigenesis in p53-deficient mice.

2001 • 84 citations

Aberrant expression and function of p53 in T‐cells immortalized by HTLV‐I Tax1

1997 • 81 citations

Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells.

2000 • 70 citations

Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis.

2000 • 63 citations

Adenoviral Bak overexpression mediates caspase-dependent tumor killing.

2000 • 54 citations

Evaluation of GAL4/TATA in Vivo

1998 • 48 citations

Different expression patterns of Bcl-2 family genes in breast cancer by estrogen receptor status with special reference to pro-apoptotic Bak gene

2000 • 35 citations

Mutant p53: Epigenetic mutator of the T-cell receptor via induction of methylation

1999 • 7 citations