Staurosporine-induced neuronal death: multiple mechanisms and methodological implications

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Induction of a Common Pathway of Apoptosis by Staurosporine

1994 • 491 citations

Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation

1998 • 486 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

1999 • 297 citations

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

1998 • 284 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

K‐252 Compounds: Modulators of Neurotrophin Signal Transduction

1992 • 248 citations

Staurosporine-Induced Neuronal Apoptosis

1995 • 248 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases.

1996 • 223 citations

Programmed Cell Death in Neurons: Focus on the Pathway of Nerve Growth Factor Deprivation-Induced Death of Sympathetic Neurons

1997 • 220 citations

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.

1993 • 214 citations

Regional calpain and caspase-3 proteolysis of α-spectrin after traumatic brain injury

1998 • 206 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1994 • 184 citations

The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation

1993 • 181 citations

Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study

1991 • 180 citations

Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway

1996 • 174 citations

Apoptosis in neurodegenerative disorders

1997 • 171 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Death substrates come alive

1997 • 167 citations

Blocking Cytochrome c Activity within Intact Neurons Inhibits Apoptosis

1998 • 161 citations

Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat

1990 • 154 citations

K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses.

1992 • 140 citations

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1992 • 129 citations

Ca²⁺ and Reactive Oxygen Species in Staurosporine‐Induced Neuronal Apoptosis

1997 • 126 citations

Analysis of the Mechanism of Loss of Trophic Factor Dependence Associated with Neuronal Maturation: A Phenotype Indistinguishable fromBaxDeletion

1997 • 123 citations

Comparison Between the Timing of JNK activation, c‐Jun Phosphorylation, and Onset of Death Commitment in Sympathetic Neurones

1997 • 100 citations

Susceptibility to apoptosis is enhanced in immature cortical neurons

1997 • 92 citations

[20] Techniques in the tissue culture of rat sympathetic neurons

1983 • 86 citations

Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation

1998 • 82 citations

Three Distinct Phases of Fodrin Proteolysis Induced in Postischemic Hippocampus

1995 • 70 citations

Mimicry and Inhibition of Nerve Growth Factor Effects: Interactions of Staurosporine, Forskolin, and K252a in PC12 Cells and Normal Rat Chromaffin Cells In Vitro

1990 • 67 citations

Involvement of caspases in sympathetic neuron apoptosis

1997 • 66 citations

Glutamate-Treated Rat Cortical Neuronal Cultures Die in a Way Different from the Classical Apoptosis Induced by Staurosporine

1997 • 64 citations

A rapid fluorometric assay to measure neuronal survival in vitro

1993 • 63 citations

Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition.

1992 • 61 citations

Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury

1994 • 59 citations

Second‐messenger pathways involved in the regulation of survival in germinal‐centre B cells and in burkitt lymphoma lines

1992 • 46 citations

Staurosporine, K‐252a, and K‐252b Stabilize Calcium Homeostasis and Promote Survival of CNS Neurons in the Absence of Glucose

1994 • 38 citations

Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neuron in rats.

1991 • 36 citations

Role of apoptosis in acute neurodegenerative disorders

1996 • 28 citations

Morphological and Biochemical Changes in Neurons: Apoptosis versus Mitosis

1996 • 21 citations

Biphasic effect of staurosporine on thymocyte apoptosis.

1995 • 14 citations