Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Caspases: killer proteases

1997 • 2,440 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Small Stress Proteins as Novel Regulators of Apoptosis

1996 • 614 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

1999 • 573 citations

Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

1996 • 568 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

1996 • 484 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein.

1988 • 356 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

hsp27 as a Switch between Differentiation and Apoptosis in Murine Embryonic Stem Cells

1997 • 220 citations

Phosphorylation of αB-Crystallin in Response to Various Types of Stress

1997 • 207 citations

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans

1994 • 195 citations

Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells

1992 • 154 citations

CED-4—The Third Horseman of Apoptosis

1997 • 116 citations

The serum‐induced phosphorylation of mammalian hsp27 correlates with changes in its intracellular localization and levels of oligomerization

1994 • 114 citations

Tissue-specific expression of the heat shock protein HSP27 during Drosophila melanogaster development.

1990 • 105 citations

Intracellular reactive oxygen species as apparent modulators of heat-shock protein 27 (hsp27) structural organization and phosphorylation in basal and tumour necrosis factor α-treated T47D human carcinoma cells

1995 • 100 citations

Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells.

1993 • 82 citations

Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28).

1992 • 82 citations

Dynamic Changes in the Structure and Intracellular Locale of the Mammalian Low-Molecular-Weight Heat Shock Protein

1988 • 75 citations

Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

1999 • 71 citations

The small heat shock protein hsp25 is accumulated in P19 embryonal carcinoma cells and embryonic stem cells of line BLC6 during differentiation

1992 • 51 citations

Transient accumulation, phosphorylation and changes in the oligomerization of Hsp27 during retinoic acid-induced differentiation of HL-60 cells: possible role in the control of cellular growth and differentiation

1996 • 50 citations

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion

1994 • 48 citations

High Yield Purification of a Four Subunit caa3-Type Cytochrome Oxidase from the Thermophilic Bacterium Bacillus PS3 Using Fast Protein Liquid Chromatography

1995 • 17 citations