Bcl-xS and Bax induce different apoptotic pathways in PC12 cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Caspases: killer proteases

1997 • 2,440 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Bcl-2 family proteins

1998 • 1,055 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

1988 • 687 citations

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1998 • 641 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1997 • 357 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Angiotensin Type 2 Receptor Dephosphorylates Bcl-2 by Activating Mitogen-activated Protein Kinase Phosphatase-1 and Induces Apoptosis

1997 • 301 citations

A system for characterizing cellular and molecular events in programmed neuronal cell death

1993 • 267 citations

New members of the Bcl-2 family and their protein partners

1996 • 248 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy

1997 • 179 citations

Boo, a novel negative regulator of cell death, interacts with Apaf-1

1999 • 177 citations

Deciphering the pathways of life and death

1999 • 175 citations

Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death

1998 • 170 citations

Bcl-2 Prevents Caspase-independent Cell Death

1998 • 162 citations

Induction of CPP32-like Activity in PC12 Cells by Withdrawal of Trophic Support

1996 • 146 citations

Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation.

1995 • 140 citations

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

1995 • 134 citations

Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL

1998 • 129 citations

Bax and Bcl-xS are induced at the onset of apoptosis in involuting mammary epithelial cells

1996 • 121 citations

Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2

1998 • 114 citations

Blk, a BH3-containing Mouse Protein That Interacts with Bcl-2 and Bcl-xL, Is a Potent Death Agonist

1998 • 113 citations

Caspase-2 (Nedd-2) Processing and Death of Trophic Factor-Deprived PC12 Cells and Sympathetic Neurons Occur Independently of Caspase-3 (CPP32)-Like Activity

1998 • 113 citations

The killer and the executioner: how apoptosis controls malignancy

1995 • 104 citations

Apoptosis: Bcl-2-related proteins get connected

1997 • 100 citations

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

1996 • 91 citations

Death by Dozens of Cuts

1998 • 87 citations

BCL‐2‐Related Protein Expression in Apoptosis: Oxidative Stress Versus Serum Deprivation in PC12 Cells

1997 • 85 citations

Bcl-Xshort is elevated following severe global ischemia in rat brains

1997 • 83 citations

Inhibition of Drug‐Induced Apoptosis by Survival Factors in PC12 Cells

1995 • 77 citations

Nerve Growth Factor Protects PC12 Cells Against Peroxynitrite‐Induced Apoptosis via a Mechanism Dependent on Phosphatidylinositol 3‐Kinase

1997 • 75 citations

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

1997 • 72 citations

Bcl-2 Counters Apoptosis by Bax Heterodimerization-dependent and -independent Mechanisms in the T-cell Lineage

1997 • 69 citations

Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons

1998 • 64 citations

Need for caspase-2 in apoptosis of growth-factor-deprived PC12 cells

1998 • 48 citations

Nerve Growth Factor Rescues PC12 Cells from Apoptosis by Increasing Amount of bcl-2

1996 • 47 citations

Apoptosis and Bcl-xs in the intimal thickening of balloon-injured carotid arteries

1999 • 42 citations

Subcellular Distribution and Redistribution of Bcl-2 Family Proteins in Human Leukemia Cells Undergoing Apoptosis

1999 • 5 citations