Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

GLUTATHIONE

1983 • 5,487 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Protein Oxidation and Aging

1992 • 2,687 citations

[38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay

1994 • 2,372 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin

1990 • 869 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

1994 • 637 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

Chaperone activity of alpha-crystallins modulates intermediate filament assembly.

1994 • 415 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

1994 • 373 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

A Prospectus for Multispectral-Multiplex DNA Sequencing

1989 • 233 citations

Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein.

1991 • 227 citations

14 Expression and Function of the Low-molecular-weight Heat Shock Proteins

1994 • 223 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells.

1991 • 201 citations

Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent

1986 • 187 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2.

1993 • 149 citations

Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis.

1988 • 142 citations

Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion.

1983 • 131 citations

Cytoskeleton as a target in menadione‐induced oxidative stress in cultured mammalian cells. I. Biochemical and immunocytochemical features

1990 • 130 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

Tumor Necrosis Factor Induces the Rapid Phosphorylation of the Mammalian Heat Shock Protein hsp28

1990 • 125 citations

Tumor necrosis factor‐α induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine

1995 • 114 citations

Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

1989 • 111 citations

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.

1992 • 107 citations

Tissue-specific expression of the heat shock protein HSP27 during Drosophila melanogaster development.

1990 • 105 citations

Intracellular reactive oxygen species as apparent modulators of heat-shock protein 27 (hsp27) structural organization and phosphorylation in basal and tumour necrosis factor α-treated T47D human carcinoma cells

1995 • 100 citations

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity

1993 • 97 citations

Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes

1992 • 84 citations

Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor

1990 • 70 citations

Doxorubicin‐induced lipid peroxidation and glutathione peroxidase activity in tumor cell lines selected for resistance to doxorubicin

1993 • 54 citations

The Fas/APO-1 receptor and its deadly ligand

1994 • 50 citations

Cytolysis by tumor necrosis factor is preceded by a rapid and specific dissolution of microfilaments.

1989 • 45 citations

Role of glutathione and hsp 70 in the acquisition of thermotolerance in postimplantation rat embryos

1991 • 45 citations

Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells.

1994 • 44 citations

Effects of tumor necrosis factor-alpha on peroxidation of plasma lipoprotein lipids in experimental animals and patients

1992 • 30 citations

The kinetics of HIV-1 long terminal repeat transcriptional activation resemble those of hsp70 promoter in heat-shock treated HeLa cells

1994 • 27 citations