Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line

1982 • 674 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Use of bromodeoxyuridine-immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system

1988 • 604 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Differential expression of myc family genes during murine development

1986 • 542 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment

1986 • 536 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Cell death during differentiation of the retina in the mouse

1984 • 531 citations

Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas

1983 • 504 citations

Myc and Max associate in vivo.

1992 • 428 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

The role of c-myc in cell growth

1993 • 365 citations

Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

1992 • 365 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

Perspectives on mammalian cell death

1988 • 334 citations

Two human c-onc genes are located on the long arm of chromosome 8.

1982 • 329 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation

1986 • 321 citations

Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.

1992 • 314 citations

Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line

1986 • 309 citations

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

1993 • 294 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Oncogene-induced liver neoplasia in transgenic mice.

1989 • 249 citations

myc Family Oncogenes in the Development of Normal and Neoplastic Cells

1991 • 245 citations

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

1985 • 242 citations

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

1994 • 242 citations

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis

1991 • 220 citations

c-myc as an inducer of polycystic kidney disease in transgenic mice

1991 • 210 citations

Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse

1993 • 206 citations

Oncogenesis of the Lens in Transgenic Mice

1987 • 202 citations

Mouse c-myc Oncogene Is Located on Chromosome 15 and Translocated to Chromosome 12 in Plasmacytomas

1982 • 197 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization.

1988 • 194 citations

Determination of the c-MYC DNA-binding site.

1991 • 181 citations

The c-myc proto-oncogene regulates cardiac development in transgenic mice.

1990 • 181 citations

Immunocytochemical localization of the lens main intrinsic polypeptide (MIP26) in communicating junctions.

1982 • 179 citations

Expression of N-myc in teratocarcinoma stem cells and mouse embryos

1985 • 173 citations

Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.

1989 • 172 citations

Enhanced expression of the N-myc gene in Wilms' tumors.

1986 • 170 citations

Control of lens epithelial cell survival.

1993 • 161 citations

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

1990 • 153 citations

The role of cell death during morphogenesis of the mammalian eye

1973 • 151 citations

Lens membranes II. Isolation and characterization of the main intrinsic polypeptide (MIP) of bovine lens fiber membranes

1976 • 151 citations

The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.

1991 • 148 citations

TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein.

1993 • 146 citations

Structure and expression of the murine N-myc gene.

1986 • 146 citations

Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.

1985 • 132 citations

The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.

1987 • 130 citations

Sequence-specific DNA binding by Myc proteins.

1991 • 130 citations

Dynamic Expression Pattern of the myc Protooncogene in Midgestation Mouse Embryos

1989 • 129 citations

Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.

1992 • 129 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

1994 • 125 citations

Induction of the Eye Lens

1980 • 111 citations

Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue.

1988 • 108 citations

A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis

1991 • 107 citations

Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing.

1988 • 102 citations

Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney.

1991 • 93 citations

L-myc cooperates with ras to transform primary rat embryo fibroblasts.

1988 • 93 citations

Structure and expression of the murine L-myc gene.

1987 • 85 citations

Activation Domains of L-Myc and c-Myc Determine Their Transforming Potencies in Rat Embryo Cells

1992 • 77 citations

Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution.

1993 • 76 citations

Expression of N-myc and c-src during the development of fetal human brain.

1987 • 71 citations

Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.

1994 • 66 citations

Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein

1992 • 63 citations

Heat induced aggregation of the sodium dodecyl sulfate-solubilized main intrinsic polypeptide isolated from bovine lens plasma membrane

1978 • 62 citations

The c-myc Proto-Oncogene Regulates Cardiac Development in Transgenic Mice

1990 • 56 citations

Complex lymphoid and epithelial thymic tumours in Thyl-myc transgenic mice

1989 • 54 citations

Nuclear events after activation of CD4+8+ thymocytes.

1990 • 50 citations

Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice.

1989 • 48 citations

c-myc mRNA is elevated as differentiating lens cells withdraw from the cell cycle

1987 • 45 citations

Structural organization of the murine c-kit proto-oncogene.

1992 • 43 citations

IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.

1990 • 41 citations

Changes in membrane protein pattern in relation to lens cell differentiation

1977 • 40 citations

Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation.

1989 • 39 citations

The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs.

1988 • 36 citations

DNA binding by N- and L-Myc proteins.

1993 • 34 citations

Functional analysis at the Cys706 residue of the retinoblastoma protein.

1992 • 30 citations

Structure and Expression of the Human L-myc Gene Reveal a Complex Pattern of Alternative mRNA Processing

1988 • 29 citations

Chromosomal location of N-myc and L-myc genes in the mouse.

1989 • 25 citations

Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.

1991 • 23 citations

Changes in the Major Intrinsic Polypeptide (MIP26K) during opacification of the Emory mouse lens

1988 • 23 citations

Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors.

1991 • 20 citations

A Transfected L-myc Gene Can Substitute for c-myc in Blocking Murine Erythroleukemia Differentiation

1989 • 20 citations

Zebra Fish myc Family and max Genes: Differential Expression and Oncogenic Activity throughout Vertebrate Evolution

1993 • 17 citations

Complex Transcriptional Regulation of myc Family Gene Expression in the Developing Mouse Brain and Liver

1991 • 10 citations

Mechanism of Endogenous myc Gene Down-Regulation in Eμ-N-myc Tumors

1991 • 8 citations