Small Stress Proteins as Novel Regulators of Apoptosis

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

The Fas Death Factor

1995 • 4,070 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.

1982 • 792 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Regulators of cell death

1995 • 647 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Death and the cell

1986 • 616 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

The role of DNA fragmentation in apoptosis

1995 • 608 citations

Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

1996 • 568 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines

1994 • 192 citations

Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress.

1993 • 163 citations

Tissue‐specific expression of heat shock proteins of the mouse in the absence of stress

1993 • 162 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

Tumor necrosis factor‐α induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine

1995 • 114 citations

Intracellular reactive oxygen species as apparent modulators of heat-shock protein 27 (hsp27) structural organization and phosphorylation in basal and tumour necrosis factor α-treated T47D human carcinoma cells

1995 • 100 citations

Essential genes that regulate apoptosis

1994 • 87 citations

Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28).

1992 • 82 citations

The Fas/APO-1 receptor and its deadly ligand

1994 • 50 citations

Segregation of APO‐1/Fas antigen‐ and tumor necrosis factor receptor‐mediated apoptosis

1994 • 46 citations

Data base analysis of protein expression patterns during T-cell ontogeny and activation.

1993 • 40 citations

Cytotoxic manifestations of the interaction between hyperthermia and TNF: DNA fragmentation

1994 • 15 citations