Effects and mechanisms of action of endothelins on non-vascular smooth muscle of the respiratory, gastrointestinal and urogenital tracts

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

1993 • 1,829 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Polar secretion of endothelin-1 by cultured endothelial cells.

1992 • 650 citations

Molecular characterization of endothelin receptors

1992 • 601 citations

Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.

1993 • 576 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.

1990 • 462 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Cloning and characterization of an endothelin-3 specific receptor (ETC receptor) from Xenopus laevis dermal melanophores.

1993 • 373 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

Women with Preeclampsia have Higher Plasma Endothelin Levels than Women with Normal Pregnancies

1990 • 344 citations

Growth regulatory properties of endothelins

1993 • 342 citations

Influence of Sex Hormones on Plasma Endothelin Levels

1993 • 328 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelins: multifunctional renal peptides.

1993 • 306 citations

Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor

1988 • 304 citations

Secretory mechanism of immunoreactive endothelin in cultured bovine endothelial cells

1989 • 304 citations

Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?

1989 • 299 citations

Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells

1994 • 291 citations

Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis

1993 • 284 citations

Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat

1989 • 260 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Eridothelin immunoreactivity of airway epithelium in asthmatic patients

1991 • 247 citations

The Physiology of Gastric Acid Secretion

1988 • 245 citations

Physiology and pharmacology of endothelins

1992 • 239 citations

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA

1991 • 226 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Endothelins: circulating plasma levels and presence in other biologic fluids.

1993 • 207 citations

Maternal plasma level of endothelin is increased in preeclampsia

1991 • 203 citations

The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes

1991 • 194 citations

Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction

1991 • 194 citations

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

1989 • 184 citations

The structure and specificity of endothelin receptors: Their importance in physiology and medicine

1993 • 182 citations

Formation of endothelin by cultured airway epithelial cells

1989 • 180 citations

Use of the endothelin antagonists BQ‐123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF

1993 • 177 citations

Endothelin Stimulation of Cytosolic Calcium and Gonadotropin Secretion in Anterior Pituitary Cells

1990 • 172 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

1993 • 168 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Production of endothelin in human cancer cell lines.

1990 • 165 citations

Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells.

1991 • 158 citations

Similarities in mode and sites of action of sarafotoxins and endothelins

1989 • 152 citations

High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis

1992 • 151 citations

Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension

1992 • 151 citations

Urinary excretion of endothelin-1 in normal subjects and patients with renal disease

1991 • 150 citations

Nitric oxide and relaxation of pig lower urinary tract

1992 • 148 citations

The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis

1992 • 146 citations

Neuropeptide Y—A cotransmitter with noradrenaline and adenosine 5′-Triphosphate in the sympathetic nerves of the mouse vas deferens? A biochemical, physiological and electropharmacological study

1986 • 142 citations

Specific Binding of Endothelin on Human Bronchial Smooth Muscle Cells in Culture and Secretion of Endothelin-like Material from Bronchial Epithelial Cells

1990 • 140 citations

Distribution of Endothelin-like Immunoreactivity and mRNA in the Developing and Adult Human Lung

1991 • 136 citations

Effects of endothelin on the mechanical activity and cytosolic calcium levels of various types of smooth muscle

1989 • 133 citations

Endothelin-1 Participation in Overt and Inflammatory Pain

1989 • 130 citations

Contractile activity of three endothelins (ET‐1, ET‐2 and ET‐3) on the human isolated bronchus

1990 • 126 citations

A novel subtype of endothelin receptors.

1992 • 126 citations

Endothelin receptor subtypes in human and guinea‐pig pulmonary tissues

1993 • 123 citations

Pituitary site of action of endothelin: Selective inhibition of prolactin release in vitro

1990 • 122 citations

Endothelin in the gastrointestinal tract

1990 • 121 citations

cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2

1991 • 120 citations

Endothelin-1 in the Human Prostate: Tissue Levels, Source of Production and Isometric Tension Studies

1993 • 120 citations

Characterization of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man.

1992 • 118 citations

Two different forms of endothelin receptors in rat lung

1989 • 117 citations

Increased Expression of Endothelin in Bronchial Epithelial Cells of Asthmatic Patients and Effect of Corticosteroids

1992 • 115 citations

Endothelin-1 enhances superoxide generation of human neutrophils stimulated by the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine

1990 • 115 citations

Effects of endothelin‐1 on vascular permeability in the conscious rat: interactions with platelet‐activating factor

1991 • 113 citations

The activity of peptides of the endothelin family in various mammalian smooth muscle preparations

1989 • 108 citations

Localization of endothelin‐like immunoreactivity in airway epithelium of rats and mice

1990 • 104 citations

Endothelial vasoactive mediators in preeclampsia

1993 • 104 citations

Potent contractile effect of endothelin in isolated guinea-pig airways

1989 • 104 citations

Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1

1992 • 100 citations

Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines

1992 • 99 citations

Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors

1989 • 98 citations

Relationship between endothelin‐1 binding site densities and constrictor activities in human and animal airway smooth muscle

1990 • 98 citations

The pharmacological properties of the peptide, endothelin

1989 • 97 citations

Cloning and characterization of cDNA encoding human a-type endothelin receptor

1991 • 97 citations

The mucoid cap over superficial gastric damage in the rat

1990 • 96 citations

Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung

1992 • 96 citations

Actions of endothelin on isolated corpus cavernosum from rabbit and man

1990 • 96 citations

Heterogeneity of endothelin‐sarafotoxin receptors mediating contraction of pig coronary artery

1992 • 95 citations

Characterization of Endothelin-1 Stimulation of Catecholamine Release from Adrenal Chromaffin Cells

1989 • 93 citations

The C-terminal hexapeptide, endothelin-(16–21), discriminates between different endothelin receptors

1989 • 91 citations

Purification and characterization of bovine lung endothelin receptor.

1991 • 90 citations

Endothelin-1 Releases Eicosanoids from Rabbit Isolated Perfused Kidney and Spleen

1989 • 88 citations

Endothelin induces two types of contractions of rat uterus: Phasic contractions by way of voltage-dependent calcium channels and developing contractions through a second type of calcium channels

1989 • 88 citations

Potent cyclo-oxygenase-mediated bronchoconstrictor effects of endothelin in the guinea-pig in vivo

1988 • 88 citations

Endothelins and sarafotoxins: Physiological regulation, receptor subtypes and transmembrane signaling

1992 • 87 citations

Induction of rat gastric damage by the endothelium‐derived peptide, endothelin

1988 • 87 citations

Endothelin increases cytoplasmic calcium and myosin phosphorylation in human myometrium

1990 • 87 citations

Endothelin-1 gene expression and protein biosynthesis in human endometrium: potential modulator of endometrial blood flow.

1992 • 87 citations

Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells

1989 • 86 citations

Receptors and neurosecretory actions of endothelin in hypothalamic neurons.

1991 • 86 citations

Localization of endothelinlike immunoreactivity and endothelin binding sites in human colon

1991 • 86 citations

Endothelins activate Na+/H+ exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C.

1991 • 86 citations

Endothelin peptides: Biological actions and pathophysiological significance in the lung

1993 • 85 citations

Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach

1989 • 83 citations

Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig

1989 • 83 citations

Localization of Endothelin Receptors in the Human Prostate

1994 • 82 citations

Endothelin‐1 (ET‐1)‐induced contraction in rat isolated trachea: involvement of ET<scp>a</scp> and ET_B receptors and multiple signal transduction systems

1993 • 82 citations

Specific receptors for endothelin on membranes from human placenta. Characterization and use in a binding assay

1989 • 82 citations

Differential activities of two distinct endothelin family peptides on ileum and coronary artery

1989 • 81 citations

Mechanisms of endothelin-mediated bronchoconstriction in the guinea pig.

1989 • 78 citations

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

1991 • 78 citations

Endothelin: presence in human umbilical vessels, high levels in fetal blood and potent constrictor effect

1989 • 77 citations

Immunolocalization, binding, and biological activity of endothelin in rabbit uterus: effect of ovarian steroids

1991 • 76 citations

Airway epithelium-derived inhibitory factor

1990 • 75 citations

Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue

1990 • 75 citations

Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor

1992 • 74 citations

Enhancement by endothelin‐1 of microvascular permeability via the activation of ET_A receptors

1993 • 72 citations

Characterization, localization and actions of endothelins in umbilical vessels and placenta of man

1991 • 71 citations

The mechanism of action of endothelin in human lung

1991 • 70 citations

Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung

1990 • 70 citations

Sarafotoxins and endothelins: evolution, structure and function

1993 • 69 citations

Endothelin receptors in human placenta: relationship to vascular resistance and thromboxane release

1990 • 68 citations

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

1990 • 68 citations

Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle.

1992 • 68 citations

Biochemical and functional characterization of endothelin peptides with special reference to vascular effects.

1991 • 68 citations

Purification of an endothelin receptor from human placenta

1990 • 67 citations

Cholinergic neuromodulation by endothelin in guinea pig ileum

1989 • 67 citations

Multiple subtypes of endothelin receptors in porcine tissues: characterization by ligand binding, affinity labeling and regional distribution

1991 • 66 citations

Detection of endothelin immunoreactivity and mRNA in pulmonary tumours

1990 • 66 citations

Endothelin-1 gene expression and regulation of endothelin mRNA and protein biosynthesis in avascular human amnion. Potential source of amniotic fluid endothelin.

1991 • 64 citations

Functional endothelin/sarafotoxin receptors in the rat uterus

1989 • 64 citations

Hepatic effects of endothelin. Receptor characterization and endothelin-induced signal transduction in hepatocytes

1992 • 64 citations

Localization and production of immunoreactive endothelin-1 in the trophoblast of human placenta

1993 • 63 citations

A novel ETA‐receptor antagonist, FR 139317, inhibits endothelin‐induced contractions of guinea‐pig pulmonary arteries, but not trachea

1993 • 63 citations

Endothelins Inhibit Luteinization of Cultured Porcine Granulosa Cells*

1991 • 63 citations

Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages

1991 • 61 citations

Endothelin in the Urinary Bladder. I. Synthesis of Endothelin-1 by Epithelia, Smooth Muscle and Fibroblasts Suggests Autocrine and Paracrine Cellular Regulation

1992 • 60 citations

Identification of high affinity endothelin-1 receptor subtypes in human tissues

1991 • 60 citations

Block of Endothelin‐1‐induced release of thromboxane A₂ from the guinea pig lung and nitric oxide from the rabbit kidney by a selective ET_B receptor antagonist, BQ‐788

1994 • 60 citations

Endothelin-1 enhances vascular permeability in conscious rats: role of thromboxane A2

1992 • 59 citations

Increased Endothelin-Like Immunoreactive Material on Bronchoalveolar Lavage Fluid from Patients with Bronchial Asthma and Patients with Interstitial Lung Disease

1993 • 59 citations

Expression and regulation of endothelin precursor mRNA m avascular human amnion

1990 • 58 citations

Massive amounts of immunoreactive endothelin in human seminal fluid.

1992 • 58 citations

One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta

1990 • 58 citations

Immunoreactive endothelin concentrations in maternal and fetal blood

1990 • 57 citations

Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid

1990 • 56 citations

Production of Endothelin-1 and Big-Endothelin-1 by Tumor Cells with Epithelial-Like Morphology

1989 • 56 citations

Tissue selectivity of endothelin

1989 • 55 citations

Localization of immunoreactive endothelin and proendothelin in the human lung

1992 • 55 citations

Regional distribution and pharmacological characterization of [125I] endothelin-1 binding sites in human fetal placental vessels

1991 • 55 citations

Pharmacological evidence for distinct endothelin receptors in guinea‐pig bronchus and aorta

1992 • 53 citations

Rat testicular myoid cells respond to endothelin: characterization of binding and signal transduction pathway.

1993 • 52 citations

Studies with Endothelin-3 and Endothelin-1 on Rat Blood Pressure and Isolated Tissues

1989 • 52 citations

NEUROHYPOPHYSEAL HORMONE REGULATION OF ENDOTHELIN SECRETION FROM RABBIT ENDOMETRIAL CELLS IN PRIMARY CULTURE

1990 • 52 citations

Endothelin-1 is an autocrine factor in rat inner medullary collecting ducts

1992 • 51 citations

Endothelin receptors stimulate both phospholipase C and phospholipase D activities in different cell lines

1993 • 51 citations

Mechanism of endothelin‐induced contraction in guinea‐pig trachea: comparison with rat aorta

1990 • 51 citations

Immunochemical characterization and localization of endothelin ETB receptor

1993 • 50 citations

Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit.

1992 • 50 citations

Human big‐endothelin‐1 and endothelin‐1 release prostacyclin via the activation of ET₁ receptors in the rat perfused lung

1992 • 50 citations

Effects of endothelin on microcirculation of the pancreas

1992 • 49 citations

Human placenta expresses endothelin gene and corresponding protein is excreted in urine in increasing amounts during normal pregnancy

1991 • 47 citations

Maternal and Fetal Levels of a Novel Polypeptide, Endothelin: Evidence for Release during Pregnancy and Delivery

1990 • 46 citations

Endothelin-1-Like Immunoreactivity in Human Urine

1991 • 46 citations

Epithelial Modulation of Airway Smooth Muscle Response to Endothelin-1

1991 • 45 citations

Role of endogenous endothelin in pathogenesis of ethanol-induced gastric mucosal injury in rats

1993 • 45 citations

Endothelin-like immunoreactivity in human endometrium

1992 • 44 citations

Effects of human relaxin on isolated rat and human myometrium and uteroplacental arteries.

1991 • 44 citations

Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin‐1 in the pithed rat

1989 • 44 citations

Expression of the Three Endothelin Genes and Plasma Levels of Endothelin in Pre-Eclamptic and Normal Gestations

1993 • 44 citations

Endothelin-1 gene expression and protein biosynthesis in human endometrium: potential modulator of endometrial blood flow

1992 • 44 citations

Induction by endothelin‐1 of epithelium‐dependent relaxation of guinea‐pig trachea in vitro: role for nitric oxide

1993 • 43 citations

Involvement of ET_A receptors in the facilitation by endothelin‐1 of non‐adrenergic non‐cholinergic transmission in the rat urinary bladder

1994 • 43 citations

Plasma endothelin-1 and big endothelin-1 levels in women with pre-eclampsia

1993 • 42 citations

Endothelin-1: Immunocytochemistry, localization of binding sites, and contractile effects in human uteroplacental smooth muscle

1993 • 42 citations

Comparison of the effects of endothelin-1 and endothelin-3 on the rat stomach

1989 • 42 citations

The Hemodynamic Effects of Endothelin-1 in the Pithed Rat

1989 • 42 citations

Analysis of endothelin‐1‐induced contractions of guinea‐pig trachea, pulmonary veins and different types of pulmonary arteries

1990 • 42 citations

Cellular localization of membrane metalloendopeptidase (enkephalinase) in human endometrium during the ovarian cycle.

1993 • 41 citations

Different pharmacological profiles of big‐endothelin‐3 and big‐endothelin‐1 in vivo and in vitro

1991 • 41 citations

Contractile effects of endothelin‐I and localization of endothelin binding sites in rabbit lower urinary tract smooth muscle

1990 • 41 citations

Functional and Autoradiographic Studies of Endothelin-1 and Endothelin-2 in Human Bronchi, Pulmonary Arteries, and Airway Parasympathetic Ganglia

1991 • 41 citations

Endothelin regulation of mucus glycoprotein secretion from feline tracheal submucosal glands

1992 • 41 citations

Immunolocalization of the vasoconstrictor endothelin in human endometrium during the menstrual cycle and in umbilical cord at birth

1992 • 41 citations

Differential effects of BQ‐123 against endothelin‐1 and endothelin‐3 on the rat vas deferens: evidence for an atypical endothelin receptor

1993 • 40 citations

Massive amounts of immunoreactive endothelin in human seminal fluid

1992 • 40 citations

Guinea-pig tracheal epithelium and endothelin

1989 • 40 citations

Endothelin induces thromboxane release and contraction of isolated guinea-pig airways

1990 • 40 citations

Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

1991 • 40 citations

Endothelin modulation of neuroeffector transmission in rat and guinea pig vas deferens

1990 • 39 citations

Evidence for multiple endothelin receptors in the guinea‐pig pulmonary artery and trachea

1992 • 39 citations

The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.

1992 • 39 citations

Role of endothelin ETB receptors in bronchoconstrictor and vasoconstrictor responses in guinea pigs

1993 • 39 citations

Localization and endogenous concentration of endothelin-like immunoreactivity in human placenta

1991 • 39 citations

Autoradiographic localization of endothelin‐1 binding sites in human colonic cancer tissue

1992 • 38 citations

Analysis of cardiovascular and pulmonary responses to endothelin-1 and endothelin-3 in the anesthetized cat.

1990 • 37 citations

Biochemical characterization and autoradiographic localization of [125I]endothelin-1 binding sites on trophoblast and blood vessels of human placenta.

1993 • 37 citations

Endothelins: functional and autoradiographic studies in guinea pig trachea.

1991 • 37 citations

Effects of endothelin on cytosolic Ca2+ level and mechanical activity in rat uterine smooth muscle

1992 • 37 citations

[Endothelium-derived contracting factors].

1989 • 37 citations

High levels of immunoreactive endothelin-1 in human follicular fluids

1993 • 37 citations

Phosphoramidon blocks big‐endothelin‐1 but not endothelin‐1 enhancement of vascular permeability in the rat

1992 • 36 citations

Endothelin: Differential effects in vascular and nonvascular smooth muscle

1989 • 36 citations

Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle

1991 • 35 citations

Characterization of endothelin receptors mediating the effects of the endothelin/sarafotoxin peptides on autonomic neurotransmission in the rat vas deferens and guinea‐pig ileum

1993 • 35 citations

Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography

1991 • 35 citations

Endothelin‐1‐induced [³H]‐inositol phosphate accumulation in rat trachea

1992 • 35 citations

Pharmacological modulation of endothelin‐induced contraction of guinea‐pig isolated airways and thromboxane release

1991 • 34 citations

Endothelin- and oxytocin-induced calcium signaling in cultured human myometrial cells.

1991 • 34 citations

Biphasic effects of endothelin in the guinea-pig ileum

1990 • 34 citations

Characterization of endothelin converting enzyme in rat lung

1990 • 34 citations

Further studies on the response of the guinea-pig isolated bronchus to endothelins and sarafotoxin S6b

1990 • 34 citations

Contractile Effects of Endothelin 1 and Endothelin 3 on Myometrium and Small Intramyometrial Arteries of Pregnant Women at Term

1993 • 34 citations

Endothelin-1-induced nociception

1991 • 34 citations

Endothelin-1 in luteal tissue

1991 • 33 citations

Local Motor Responses to Bradykinin and Bacterial Chemotactic Peptide Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) in the Guinea-Pig Isolated Renal Pelvis and Ureter

1992 • 33 citations

Increase in the concentration of immunoreactive endothelin in human pregnancy

1991 • 33 citations

Gastric ulcer induced by submucosal injection of ET-1: role of potent vasoconstriction and intraluminal acid

1993 • 33 citations

Differential localization of endothelin ETa and ETB binding sites in human placenta

1993 • 33 citations

Endothelin Modulation of Neuroeffector Transmission in Smooth Muscle

1991 • 32 citations

Actions of endothelin-1 on prostaglandin production by gestational tissues

1990 • 32 citations

Production of Eicosanoids in Response to Endothelin-1 and Identification of Specific Endothelin-1 Binding Sites in Airway Epithelial Cells

1993 • 32 citations

Effects of tumour cells on angiogenesis and vasoconstrictor responses in sponge implants in mice

1992 • 32 citations

Endothelin production by amnion and its regulation by cytokines

1991 • 32 citations

Presence of a phosphoramidon-sensitive endothelin-converting enzyme which converts big-endothelin-1, but not big-endothelin-3, in the rat vas deferens

1991 • 32 citations

Comparison of the effects of intra‐arterial and aerosol administration of endothelin‐1 (ET‐1) in the guinea‐pig isolated lung

1991 • 31 citations

Contractile effects and binding properties of endothellns/sarafotoxins in the guinea pig ileum

1991 • 31 citations

Interactions between the vascular peptide endothelin‐1 and sensory neuropeptides in gastric mucosal injury

1991 • 31 citations

SK&amp;F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells

1991 • 30 citations

Comparison of the Bronchopulmonary and Pressor Activities of Endothelin Isoforms ET-1, ET-2, and ET-3 and Characterization of Their Binding Sites in Guinea Pig Lung

1991 • 30 citations

Bronchopulmonary and vascular effect of endothelin in the guinea-pig

1990 • 30 citations

Intestinal relaxation by endothelin isopeptides: involvement of Ca2+-activated K+ channels

1992 • 30 citations

Role of thromboxane receptor activation in the bronchospastic response to endothelin

1990 • 30 citations

Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage

1992 • 30 citations

Endothelins constrict guinea pig tracheas by multiple mechanisms.

1992 • 30 citations

Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle

1992 • 30 citations

Endothelin, a vasoconstrictor important to the uteroplacental circulation in pre-eclampsia

1991 • 30 citations

Vasoactive mediators released by endothelins

1992 • 29 citations

Effect of Endothelin-1 on Blood Pressure and Bronchopulmonary System of the Guinea Pig

1989 • 29 citations

Endothelin-1, -2 and -3 directly and big-endothelin-1 indirectly elicit an abdominal constriction response in mice

1991 • 29 citations

Ischemic Bowel Necrosis Induced by Endothelin-1: An Experimental Model in Rats

1991 • 29 citations

Potent thromboxane-mediated in vitro bronchoconstrictor effect of endothelin in the guinea-pig

1990 • 29 citations

Contraction of smooth muscle by activation of endothelin receptors on autonomic neurons

1993 • 29 citations

Effects and specific binding sites of endothelin in human lung preparations

1991 • 29 citations

Plasma Immunoreactive Endothelin-1 Concentration in Human Fetal Blood: Its Relation to Asphyxia

1991 • 29 citations

Phosphoramidon abolishes the increases in endothelin-1 release induced by ischemia-hypoxia in isolated perfused guinea pig lungs.

1992 • 28 citations

Endothelin stimulates chloride secretion across canine tracheal epithelium

1991 • 28 citations

Role of Endothelin and Platelet-Activating Factor in Indomethacin-lnduced Gastric Mucosal Injury in Rats

1993 • 28 citations

Pancreatic acini possess endothelin receptors whose internalization is regulated by PLC-activating agents

1993 • 27 citations

Central nervous system action of endothelin-3 to inhibit water drinking in the rat

1991 • 27 citations

Rat testicular myoid cells respond to endothelin: characterization of binding and signal transduction pathway

1993 • 27 citations

Endothelin-1-induced contractions of isolated pig detrusor and vesical arterial smooth muscle: Calcium dependence and phosphoinositide hydrolysis

1992 • 27 citations

Localization of Endothelin-Like Immunoreactivity and Endothelin Binding Sites in Rabbit Eyes

1995 • 27 citations

Endothelin-1 stimulates prostaglandin F2α release from human endometrium

1991 • 27 citations

Endothelin levels in human amniotic fluid at mid-trimester and at term before and during spontaneous labor.

1993 • 27 citations

Endothelin, vasopressin, and substance P like immunoreactivity in cultured and intact epithelium from rabbit trachea.

1992 • 27 citations

Endothelin modulates calcium channel current in neurones of rabbit pelvic parasympathetic ganglia

1991 • 26 citations

Human Big Endothelin Releases Prostacyclin in vivo and in vitro Through a Phosphoramidon-Sensitive Conversion to Endothelin-1

1991 • 26 citations

Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium

1993 • 26 citations

Cardiopulmonary and Gastric Ulcerogenic Actions of Endothelin-1 in the Guinea Pig and Rat

1989 • 26 citations

Structure‐activity studies on endothelin (16–21), the C‐terminal hexapeptide of the endothelins, in the guinea‐pig bronchus

1990 • 25 citations

Phospholipase C Activation by Endothelin-1 and Noradrenaline in Isolated Penile Erectile Tissue from Rabbit

1992 • 25 citations

Distribution and molecular form of immunoreactive big endothelin-1 in porcine tissue

1990 • 25 citations

Characterization and ontogeny of endothelin receptors in human placenta

1993 • 25 citations

Endothelin-1 from Pulmonary Artery and Micro vessels Acts on Vascular and Airway Smooth Muscle

1989 • 25 citations

Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion.

1992 • 25 citations

Contractile responses of the human urinary bladder, renal pelvis and renal artery to endothelins and sarafotoxin S6b

1990 • 25 citations

Neuromuscular actions of endothelin on smooth, cardiac and skeletal muscle from guinea‐pig, rat and rabbit

1989 • 25 citations

Localization of Endothelin Receptor Messenger Ribonucleic Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization

1993 • 24 citations

Endothelin-induced constriction of guinea pig airways: Role of platelet-activating factor

1990 • 24 citations

Endotoxin stimulates endothelin release from cultured epithelial cells of guinea-pig trachea

1991 • 24 citations

Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1.

1992 • 23 citations

Effect of intravascular ethanol on modulation of gastric mucosal integrity: possible role of endothelin-1

1992 • 23 citations

Endothelin stimulates short circuit current in a cultured epithelium

1989 • 23 citations

Endothelin-1-Induced Contractions of Vascular and Tracheal Smooth Muscle

1989 • 23 citations

A specific endothelin-1 antagonist blocks inhaled endothelin-1-induced bronchoconstriction in sheep

1993 • 22 citations

Local formation and degradation of endothelin-1 in guinea pig airway tissues

1991 • 22 citations

Different pressor and bronchoconstrictor properties of human big‐endothelin‐1, 2 (1–38) and 3 in ketamine/xylazine‐anaesthetized guinea‐pigs

1995 • 21 citations

Endothelin: a potent stimulator of intestinal ion secretion in vitro

1991 • 21 citations

Biochemical characterization and autoradiographic localization of [125I]endothelin-1 binding sites on trophoblast and blood vessels of human placenta

1993 • 21 citations

Pharmacologic Treatment of Impotence

1987 • 21 citations

Effects of endothelin on the cardiovascular system and on smooth muscle preparations in different species

1989 • 21 citations

The Biological Activity of Endothelin-1 Analogues in Three Different Assay Systems

1991 • 21 citations

A novel ligand, [125I]BQ-3020, reveals the localization of endothelin ETB receptors

1993 • 21 citations

Endothelin‐1 inhibits pre‐stimulated tracheal submucosal gland secretion and epithelial albumin transport

1991 • 21 citations

Effect of endothelin 1 on ion transport in isolated rat colon

1993 • 20 citations

Neutral endopeptidase modulates endothelin-1-induced airway smooth muscle contraction in guinea-pig trachea

1992 • 20 citations

Endothelin‐1 receptors in the human myometrium: evidence for different binding properties in post‐menopausal as compared to premenopausal and pregnant women

1993 • 20 citations

Native form of endothelin receptor in human placental membranes

1990 • 20 citations

Effects of endothelin-1 on postjunctionally-mediated purinergic and adrenergic components of rat vas deferens contractile responses

1993 • 19 citations

Neutral endopeptidase inhibitor potentiates endothelin-1-induced airway smooth muscle contraction

1992 • 19 citations

Endothelin-1 and Endothelin-3 Stimulate Ovarian Steroidogenesis

1991 • 19 citations

Effect of endothelin-1 on guinea pig gallbladder smooth muscle in vitro.

1992 • 19 citations

The role of the disulphide bonds in endothelin-1

1991 • 19 citations

Calcium dependence of the contraction produced by endothelin (ET-1) in isolated guinea-pig trachea

1990 • 19 citations

Endothelin-1 stimulates contraction and ion transport in the rat colon: different mechanisms of action.

1992 • 18 citations

Dual effects of endothelins -1, -2 and -3 on guinea pig field-stimulated ileum: possible mediation by two receptors coupled to pertussis toxin-insensitive mechanisms.

1992 • 18 citations

Electromechanical effects of endothelin on ferret bronchial and tracheal smooth muscle

1990 • 18 citations

Endothelins in reproduction

1992 • 18 citations

Cellular localization of membrane metalloendopeptidase (enkephalinase) in human endometrium during the ovarian cycle

1993 • 18 citations

Inhibition of chemiluminescence in granulocytes and alveolar macrophages by azelastine

1990 • 18 citations

Contractile activity of big endothelin‐1 on the human isolated bronchus

1992 • 17 citations

Endothelin-1 stimulates chloride and potassium secretion in rabbit descending colon

1992 • 17 citations

Involvement of a phosphoramidon-sensitive endopeptidase in the processing of big endothelin-1 in the guinea-pig

1992 • 17 citations

Activation of phospholipase A2 and phospholipase C by endothelin-1 in human endometrium

1992 • 17 citations

Specific G proteins mediate endothelin induced contraction

1992 • 17 citations

Effects of endothelin-1 on the isolated guinea-pig ileum: role of Na+ ions

1990 • 17 citations

RELAXANT EFFECTS OF BRAIN NATRIURETIC PEPTIDE ON GUINEA‐PIG TRACHEAL SMOOTH MUSCLE

1993 • 16 citations

Endothelin in rabbit uterus during pregnancy

1992 • 16 citations

Phosphoramidon potentiates the contractile response to endothelin‐3, but not endothelin‐1 in isolated airway tissue

1992 • 16 citations

Effects of endothelins, Bay K 8644 and other oxytocics in non-pregnant and late pregnant rat isolated uterus

1991 • 16 citations

Comparison of the release of vasoactive factors from venous and arterial bovine cultured endothelial cells

1992 • 16 citations

Tissue Selectivity and Calcium Dependence of Contractile Responses to Endothelin

1990 • 16 citations

Comparison of the cardiovascular and neural activity of endothelin‐1, −2, −3 and respective proendothelins: effects of phosphoramidon and thiorphan

1993 • 15 citations

The Modulation of Gastric Mucosal Integrity by Endothelin-1 and Prostacyclin

1989 • 15 citations

Endothelin-induced contraction of human peripheral resistance vessels is partly dependent on stimulation of sodium-hydrogen exchange

1989 • 15 citations

Effects of endothelins on nerve-mediated contractions of the mouse vas deferens

1990 • 15 citations

Localization of Endothelin-1 and Its Binding Sites to the Nervous System of the Human Colon

1991 • 15 citations

Endothelin levels in human amniotic fluid at mid-trimester and at term before and during spontaneous labor

1993 • 15 citations

Multiple Subtypes of Endothelin Receptors in Human and Porcine Tissues

1991 • 15 citations

Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig

1993 • 15 citations

Different Endothelin Receptor Affinities in Dog Tissues

1991 • 15 citations

Big-endothelin-1 contracts rat isolated uterus via a phosphoramidon-sensitive endothelin ETA receptor-mediated mechanism

1993 • 15 citations

Endothelin-1 (ET)-induced mobilization of intracellular Ca2+ stores from the smooth muscle facilitates sympathetic cotransmission by potentiation of adenosine 5′-triphosphate (ATP) motor activity: Studies in the rat vas deferens

1992 • 14 citations

Comparison of Endothelin-1 Concentrations in Normal and Complicated Pregnancies

1991 • 14 citations

Effects of endothelin-1 and conversion of big endothelin-1 in the isolated perfused rabbit lung

1992 • 14 citations

Properties and localization of endothelin-1-specific receptors in rat testicles

1992 • 14 citations

Effects of endothelin-3 on the isolated guinea-pig ileum: role of Na+ ions and endothelin receptor subtypes

1992 • 14 citations

Effect of endothelin-1 and vasoactive intestinal contractor on blood flow and output of vasoactive intestinal polypeptide in the feline colon

1991 • 14 citations

Concentrations of Endothelin-1 in Human Amniotic Fluid at Various Stages of Pregnancy

1991 • 14 citations

Phosphoramidon potentiates the endothelin-1-induced bronchopulmonary response in guinea-pigs

1991 • 13 citations

Newborn piglet lungs release endothelin-1: effect of α-thrombin and hypoxia

1993 • 13 citations

Endothelin differentially affects rat gastric longitudinal and circular smooth muscle.

1993 • 13 citations

Endothelin-1 Induces Contraction of Bile Canaliculi in Isolated Rat Hepatocytes

1993 • 13 citations

Endothelin-1 Stimulates Chloride Secretion across Canine Tracheal Epithelium

1992 • 12 citations

Endothelins and Sarafotoxins: Effects on Motility, Binding Properties and Phosphoinositide Hydrolysis During the Estrous Cycle of the Rat Uterus

1992 • 12 citations

Pinacidil antagonism of endothelin-induced contractions of smooth muscle in the lungs: differences between tracheal and pulmonary artery preparations.

1990 • 12 citations

A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro

1991 • 11 citations

Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor

1992 • 11 citations

Effects of endothelin-1 on vascular tension in human umbilical vessels

1991 • 11 citations

Analysis of responses to endothelins 1, 2, and 3 and sarafotoxin 6b in airways of the cat

1991 • 11 citations

Different affinities and selectivities of endothelin-1 and endothelin-3 binding to various rat tissues.

1990 • 11 citations

ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615

1992 • 11 citations

Human endometrial adenocarcinoma cells express endothelin-1

1992 • 11 citations

&lt;b&gt;SOLUBILIZATION OF TWO TYPES OF ENDOTHELIN RECEPTORS, ET&lt;sub&gt;A&lt;/sub&gt; AND ET&lt;sub&gt;B&lt;/sub&gt;, FROM RAT LUNG WITH RETENTION OF BINDING ACTIVITY &lt;/b&gt;

1991 • 11 citations

The actions of endothelins−1 and −3 on the vascular and capsular smooth muscle of the isolated blood perfused spleen of the dog

1992 • 10 citations

Visualization of¹²⁵l-Endothelin-1 Binding Sites in Human Placenta and Umbilical Vessels

1993 • 10 citations

Contractile Effects and Receptor Distributions for Endothelin-1 (ET-1) in Human and Animal Airways

1990 • 10 citations

Endothelin-1 Secretion from Cultured Rabbit Gastric Epithelial Cells

1991 • 10 citations

Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle

1993 • 10 citations

Endothelin (16–21): biphasic effect and no desensitization on the guinea‐pig isolated ileum

1993 • 9 citations

Involvement of cholinergic neurons in intestinal contraction caused by vasoactive intestinal contractor

1993 • 9 citations

Characterization of intestinal smooth muscle responses and binding sites for endothelin

1992 • 9 citations

Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver

1991 • 9 citations

Interactions between the effects of endothelin-1, clonidine and yohimbine on electrically-induced contractions in rat vas deferens

1992 • 9 citations

Rat gastric relaxation induced by stimulation of endothelin-1 selective receptors

1992 • 9 citations

Involvement of K⁺-channel opening in endothelin-1 induced suppression of spontaneous contractions in the guinea pig taenia coli

1991 • 9 citations

Cardiovascular responses to vasoactive intestinal contractor, a novel endothelin-like peptide

1990 • 9 citations

Endothelin-1-Induced Relaxation of Guinea Pig Trachealis Muscles

1991 • 8 citations

Conversion of Big Endothelin-1 in Rat Uterus Causes Contraction Mediated by ETA Receptors

1993 • 8 citations

Intracerebroventricular administration of endothelins: effects on the suprasptnal micturition reflex and blood pressure in the anaesthetized rat

1991 • 8 citations

Direct Effects on Airway Smooth Muscle Contractile Response Caused by Endothelin-1 in Guinea Pig Trachealis

1992 • 8 citations

Failure of aerosolized endothelin (ET‐1) to induce bronchial hyperreactivity in the guinea pig

1990 • 8 citations

&lt;b&gt;Vasoactive intestinal peptide (VIP) reverses endothelin-induced contractions of guinea-pig trachea and pulmonary &lt;/b&gt;&lt;b&gt;artery &lt;/b&gt;

1991 • 7 citations

Endothelin contracts human uterine myometrium by a partly dihydropyridine‐sensitive mechanism

1993 • 7 citations

Comparison of vascular and respiratory effects of endothelin‐1 in the pig

1993 • 7 citations

Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-beta, rat endothelin-2) is a potent inhibitor of prolactin secretion

1992 • 7 citations

Pharmacologic modulation of endothelin-induced contraction in isolated rat tracheal segments.

1990 • 7 citations

Effect of Prostaglandins and Capsaicin on Gastric Vascular Flow and Mucosal Injury in Endothelin-1-Treated Rats

1992 • 6 citations

Bronchopulmonary and pressor effects of big-endothelin-1 in the guinea-pig

1991 • 6 citations

Two Receptor Subtypes Are Involved in the Contractile Component of the Guinea Pig Ileum Responses to Endothelins

1993 • 6 citations

Fetal Circulatory Endothelin-1,2 in the Midtrimester

1993 • 5 citations

Mechanism of relaxing action of the antiasthmatic drug, azelastine, in isolated porcine tracheal smooth muscle

1992 • 5 citations

Oxytocin-endothelin interactions in the uterus

1993 • 5 citations

Effect of Tranilast on Endothelin-Induced Bronchoconstriction in Guinea Pigs.

1991 • 5 citations

Bronchopulmonary responses to endothelin‐1 in sensitized and challenged guinea‐pigs: role of cyclooxygenase metabolites and platelet‐activating factor

1993 • 5 citations

Endothelin and sarafotoxin: Influence on steroid-regulated motility of rat uterus

1992 • 4 citations

Endothelin-1-induced gastric ulcer is attenuated by cetraxate

1993 • 4 citations

Drug-induced modulation of endothelin-1 effects on the tone of electrically stimulated rat vas deferens.

1992 • 3 citations

Comparison of the effects of endothelin-1 and Bay k 8644 on twitch contractions of the field-stimulated rat vas deferens

1991 • 3 citations

Big Endothelin in Plasma and Amniotic Fluid

1991 • 3 citations

Binding Characteristics of [125I]Endothelin-1 in Guinea-Pig Trachea and its Displacement by Endothelin-1, Endothelin-3 and Endothelin (16–21)

1990 • 1 citations