Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency

1978 • 1,103 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Molecular characterization of endothelin receptors

1992 • 601 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Cloning and expression of human endothelin‐1 receptor cDNA

1991 • 282 citations

Cloning and functional expression of human cDNA for the ETB endothelin receptor

1991 • 273 citations

Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors.

1992 • 273 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Physiology and pharmacology of endothelins

1992 • 239 citations

Selective Natrexone-Derived Opioid Receptor Antagonists

1992 • 173 citations

Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications

1992 • 139 citations

A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors

1992 • 119 citations

Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis

1992 • 110 citations

An endothelin B receptor‐selective antagonist: IRL 1038, [Cys¹¹‐Cys¹⁵]‐endothelin‐1(11–21)

1992 • 102 citations

Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1

1992 • 100 citations

Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors.

1992 • 97 citations

Analysis of responses to endothelins in isolated porcine blood vessels by using a novel endothelin antagonist, BQ-153

1992 • 89 citations

A reversible radioligand specific for the ETB receptor: [125I]Tyr13-Suc-[Glu9,Ala11,15]-endothelin-1(8–21), [125I]IRL 1620

1992 • 78 citations

Structure and function of G protein coupled receptors

1991 • 64 citations

Conformational study of cyclo[D‐Trp‐D‐Asp‐Pro‐D‐Val‐Leu], an endothelin‐A receptor‐selective antagonist

1992 • 47 citations

The solution structure of a cyclic endothelin antagonist, BQ‐123, based on ¹H–¹H and ¹³H–¹H three bond oupling constants

1992 • 41 citations

Solution conformation of a cyclic pentapeptide endothelin antagonist Comparison of structures obtained from constrained dynamics and conformational search

1992 • 38 citations

Identification of a domain of ET_A receptor required for ligand binding

1992 • 34 citations

Structure of the Precursor for Vasoactive Intestinal Contractor (VIC)

1991 • 8 citations