Newborn piglet lungs release endothelin-1: effect of α-thrombin and hypoxia

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Increased Plasma Endothelin-1 in Pulmonary Hypertension: Marker or Mediator of Disease?

1991 • 983 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features

1979 • 497 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

The structural basis of persistent pulmonary hypertension of the newborn infant

1981 • 312 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia

1990 • 207 citations

Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells

1991 • 198 citations

Formation of endothelin by cultured airway epithelial cells

1989 • 180 citations

Regional distribution of immunoreactive endothelin in porcine tissue: Abundance in inner medulla of kidney

1989 • 164 citations

Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells

1990 • 148 citations

Endothelin-mediated stimulation of DNA synthesis in vascular smooth muscle cells

1989 • 147 citations

Endothelin 1: Mitogenic Activity on Pulmonary Artery Smooth Muscle Cells and Release from Hypoxic Endothelial Cells

1992 • 126 citations

[125I]Endothelin-l Binding Sites

1989 • 92 citations

Endothelium-Dependent Relaxations in Human Arteries

1987 • 86 citations

Thrombin-bound conformation of the C-terminal fragments of hirudin determined by transferred nuclear Overhauser effects

1990 • 79 citations

High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A.alpha. chain of human fibrinogen

1989 • 73 citations

Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.

1991 • 69 citations

Specificity of the Thrombin-Induced Release of Tissue Plasminogen Activator from Cultured Human Endothelial Cells

1986 • 55 citations

Interactions of endothelins and EDRF in bovine native endothelial cells: selective effects of endothelin-3

1992 • 44 citations

Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

1989 • 34 citations

Endothelin-1 Has a Dilator Effect on Neonatal Pig Pulmonary Vasculature

1991 • 31 citations

Effect of endothelin-1 on pulmonary resistance in rats

1990 • 17 citations

Pulmonary vascular effects of prostaglandin D2 in newborn pig

1990 • 11 citations