Physiology and pharmacology of endothelins

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

1986 • 892 citations

Seminars in perinatology.

1983 • 795 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Characterization of a coronary vasoconstrictor produced by cultured endothelial cells

1985 • 616 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Role of endothelin in cyclosporine-induced glomerular dysfunction

1990 • 368 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

1989 • 353 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

Growth factor activity of endothelin on vascular smooth muscle

1990 • 325 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor

1988 • 304 citations

Endothelin-1 and Endothelin-3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit

1989 • 302 citations

Plasma endothelin levels in hypertension and chronic renal failure.

1990 • 302 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

A sensitive sandwich-enzyme immunoassay for human endothelin

1989 • 298 citations

Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells

1989 • 285 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

1990 • 247 citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

1991 • 243 citations

Endothelin is a positive inotropic agent in human and rat heart in, vitro

1989 • 235 citations

Structure-activity relationships of endothelin: Importance of the C-terminal moiety

1988 • 220 citations

Binding and receptor down‐regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 215 citations

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

1988 • 203 citations

Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats

1988 • 199 citations

Endothelial cells in culture produce a vasoconstrictor substance

1987 • 195 citations

The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes

1991 • 194 citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

1990 • 187 citations

Cl-dependent K transport in a pure population of volume-regulating human erythrocytes

1989 • 187 citations

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

1989 • 184 citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

1989 • 176 citations

Pathophysiological role of endothelin in acute renal failure

1990 • 173 citations

Endothelin Stimulation of Cytosolic Calcium and Gonadotropin Secretion in Anterior Pituitary Cells

1990 • 172 citations

Sarafotoxins S6: Several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart

1988 • 171 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

The Human Preproendothelin-1 Gene

1989 • 166 citations

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

1991 • 165 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

1990 • 161 citations

Endothelin, a potent peptide agonist in the liver.

1990 • 161 citations

Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion.

1989 • 160 citations

Heterogeneity of cell surface endothelin receptors.

1990 • 159 citations

Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma

1991 • 158 citations

Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 • 149 citations

Endothelin acts in feline and canine cerebral arteries from the adventitial side.

1989 • 138 citations

Regional and cardiac haemodynamic responses to glyceryl trinitrate, acetylcholine, bradykinin and endothelin‐1 in conscious rats: effects of N^G‐nitro‐<scp>l</scp>‐arginine methyl ester

1990 • 134 citations

Endothelin localizes in the dorsal horn and acts on the spinal neurones: Possible involvement of dihydropyridine-sensitive calcium channels and substance P release

1989 • 134 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries

1989 • 128 citations

Dual effect of glycine on isolated rat suprachiasmatic neurons

1991 • 127 citations

Contractile activity of three endothelins (ET‐1, ET‐2 and ET‐3) on the human isolated bronchus

1990 • 126 citations

Effects of endothelin in the systemic and renal vascular beds in vivo

1988 • 125 citations

Pituitary site of action of endothelin: Selective inhibition of prolactin release in vitro

1990 • 122 citations

Localization of endothelin receptors in rat kidney

1989 • 120 citations

Structure-activity relationship of endothelin: Importance of charged groups

1989 • 120 citations

Two different forms of endothelin receptors in rat lung

1989 • 117 citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

1989 • 116 citations

Endothelin-1 enhances superoxide generation of human neutrophils stimulated by the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine

1990 • 115 citations

Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.

1990 • 113 citations

Elimination of Intravenously Injected Endothelin-1 from the Circulation of the Rat

1989 • 112 citations

Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats

1990 • 107 citations

Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor

1991 • 104 citations

Potent contractile effect of endothelin in isolated guinea-pig airways

1989 • 104 citations

Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

1990 • 104 citations

The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol

1989 • 102 citations

Characteristics of pressor response to endothelin in spontaneously hypertensive and Wistar-Kyoto rats.

1989 • 101 citations

Synthesis of the vasoconstrictor peptide endothelin in kidney cells

1989 • 99 citations

Uterine response to nerve stimulation; relation to hormonal status and catecholamines

1965 • 98 citations

Relationship between endothelin‐1 binding site densities and constrictor activities in human and animal airway smooth muscle

1990 • 98 citations

Effects of endothelin on the coronary vascular bed in open-chest dogs.

1989 • 94 citations

Characterization of Endothelin-1 Stimulation of Catecholamine Release from Adrenal Chromaffin Cells

1989 • 93 citations

Endothelin induces two types of contractions of rat uterus: Phasic contractions by way of voltage-dependent calcium channels and developing contractions through a second type of calcium channels

1989 • 88 citations

Endothelin increases cytoplasmic calcium and myosin phosphorylation in human myometrium

1990 • 87 citations

Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells

1989 • 87 citations

Endothelin-induced CA-independent contraction of the porcine coronary artery

1989 • 86 citations

Endothelins activate Na+/H+ exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C.

1991 • 86 citations

Cellular mechanisms of endothelin in rabbit aorta.

1989 • 85 citations

Endothelin-1 induces prostacyclin release from bovine aortic endothelial cells

1991 • 84 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

1989 • 81 citations

Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized rats.

1991 • 80 citations

Endothelin stimulates the release of prostacyclin from rat mesenteric arteries

1989 • 79 citations

Secretion of endothelin and related peptides from renal epithelial cell lines

1989 • 79 citations

Hypoxia stimulates endothelial cell angiotensin-converting enzyme antigen synthesis

1989 • 79 citations

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

1991 • 78 citations

Effects of endothelin on coronary flow, mechanical performance, oxygen uptake, and formation of purines and on outflow of prostacyclin in the isolated rabbit heart.

1990 • 76 citations

Immunolocalization, binding, and biological activity of endothelin in rabbit uterus: effect of ovarian steroids

1991 • 76 citations

Dual effects of carbachol on cytosolic Ca2+ and contraction in intestinal smooth muscle

1990 • 73 citations

Role of thromboxane A2/prostaglandin H2 receptor in the vasoconstrictor response of rat aorta to endothelin.

1990 • 73 citations

The mechanism of action of endothelin in human lung

1991 • 70 citations

Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.

1990 • 69 citations

Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme

1990 • 69 citations

Endothelin is a potent constrictor of the lamb ductus arteriosus

1989 • 68 citations

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

1990 • 68 citations

Endothelin-1 gene expression and regulation of endothelin mRNA and protein biosynthesis in avascular human amnion. Potential source of amniotic fluid endothelin.

1991 • 64 citations

Possible Neuroendocrine Actions of Endothelin-3

1991 • 63 citations

Regional haemodynamic effects of endothelin‐1 and endothelin‐3 in conscious Long Evans and Brattleboro rats

1990 • 59 citations

Renal and femoral vascular responses to endothelin-1 in dogs: role of prostaglandins.

1991 • 58 citations

Expression and regulation of endothelin precursor mRNA m avascular human amnion

1990 • 58 citations

Haemodynamic responses to N^G‐monomethyl‐<scp>l</scp>‐arginine in spontaneously hypertensive and normotensive Wistar‐Kyoto rats

1991 • 57 citations

Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells

1990 • 57 citations

Release of Substance P from Rat Hypothalamus and Pituitary by Endothelin

1990 • 57 citations

Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid

1990 • 56 citations

Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats.

1989 • 55 citations

Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit

1990 • 54 citations

Hemodynamic and pharmacological evaluation of the vasodilator and vasoconstrictor effects of endothelin-1 in rats.

1990 • 54 citations

Detection of immunoreactive endothelin in plasma of hemodialysis patients

1989 • 53 citations

Receptor binding activity and cytosolic free calcium response by synthetic endothelin analogs in cultured rat vascular smooth muscle cells

1989 • 53 citations

Effect of endothelin on renal function in rats

1989 • 52 citations

NEUROHYPOPHYSEAL HORMONE REGULATION OF ENDOTHELIN SECRETION FROM RABBIT ENDOMETRIAL CELLS IN PRIMARY CULTURE

1990 • 52 citations

Binding of [¹²⁵I]‐endothelin‐1 to rat cerebellar homogenates and its interactions with some analogues

1990 • 52 citations

Effects of endothelin on in vitro renin secretion

1991 • 51 citations

Vasodilator activity of endothelin-1 and endothelin-3: rapid development of cross-tachyphylaxis and dependence on the rate of endothelin administration.

1990 • 49 citations

Nickel inhibits endothelin-induced contractions of vascular smooth muscle

1990 • 48 citations

Endothelin-1 induced contraction of rat aorta: contributions made by Ca2+ influx and activation of contractile apparatus associated with no change in cytoplasmic Ca2+ level

1990 • 48 citations

Effects of endothelins (ET-1, ET-2 and ET-3) in the rabbit eye; role of prostaglandins

1991 • 47 citations

Solubilization and identification of human placental endothelin receptor

1989 • 47 citations

Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin

1990 • 46 citations

Microcirculation annual 1990

1990 • 45 citations

Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain

1989 • 44 citations

Effects of moderate hypoxia, hypercapnia and acidosis on haemodynamic changes induced by endothelin‐1 in the pithed rat

1989 • 44 citations

Regulation of endothelin-mediated calcium mobilization in vascular smooth muscle cells by isoproterenol

1991 • 43 citations

Mechanisms of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and Wistar-Kyoto rats.

1991 • 42 citations

Cardiovascular significance of endothelium-derived vasoactive factors

1992 • 40 citations

Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine

1990 • 40 citations

Guinea-pig tracheal epithelium and endothelin

1989 • 40 citations

The direct observation of arteriolar constriction induced by endothelin in vivo

1989 • 36 citations

Endothelin mediates Ca influx and release in porcine coronary smooth muscle cells

1991 • 36 citations

Cyclosporine increases endothelin-1 binding site density in cardiac cell membranes

1989 • 36 citations

The effect of endothelin on noradrenergic transmission in rat and guinea-pig atria

1989 • 35 citations

Endothelins: vasoconstrictor effects and localization in canine cerebral arteries

1991 • 35 citations

Hemodynamic and tubular effects of endothelin and thromboxane in the isolated perfused rat kidney

1989 • 33 citations

Primary action of endothelin on Ca release in bovine coronary artery smooth muscle cells

1991 • 32 citations

Vasoconstrictor effects of sarafotoxins in rabbit aorta: Structure-function relationships

1989 • 28 citations

Analysis of big endothelin-1 digestion by cathepsin D

1990 • 27 citations

Endothelin modulates calcium channel current in neurones of rabbit pelvic parasympathetic ganglia

1991 • 26 citations

Distribution and molecular form of immunoreactive big endothelin-1 in porcine tissue

1990 • 25 citations

Endothelin-1 and -3 induce the release of tissue-type plasminogen activator and Von Willebrand factor from endothelial cells

1990 • 25 citations

Endothelin-induced constriction of guinea pig airways: Role of platelet-activating factor

1990 • 24 citations

Endothelin-induced biphasic formation of 1,2-diacylglycerol in cultured rabbit vascular smooth muscle cells — Mass analysis with a radioenzymatic assay

1989 • 23 citations

Cyclooxygenase products and atrial natriuretic peptide modulate renal response to endothelin.

1990 • 23 citations

Influence of endothelin on systemic arterial pressure and regional blood flow in the cat

1989 • 22 citations

Endothelin-1 induces potent constriction of lymphatic vessels in situ

1989 • 22 citations

Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction

1989 • 20 citations

Endothelin-1 and Endothelin-3 Stimulate Ovarian Steroidogenesis

1991 • 19 citations

Calcium dependence of the contraction produced by endothelin (ET-1) in isolated guinea-pig trachea

1990 • 19 citations

Effects of porcine and rat endothelin and an analog on blood pressure in the anesthetized cat

1989 • 19 citations

Effects of endothelin-1 on the isolated guinea-pig ileum: role of Na+ ions

1990 • 17 citations

Effects of endothelins, Bay K 8644 and other oxytocics in non-pregnant and late pregnant rat isolated uterus

1991 • 16 citations

Differential effects of rat endothelin on regional blood flow in the cat

1989 • 15 citations

Interactions between endothelin-1 and other chronotropic agents in rat isolated atria

1991 • 15 citations

Endothelin releasing activity in calf serum and porcine follicular fluid

1990 • 13 citations

Activities of endothelin‐1 in the vascular network of the rabbit ear: a microangiographic study

1990 • 12 citations

Bovine Cerebellum Endothelin Receptor: Solubilization and Indentification

1990 • 11 citations

A proposed structural model of endothelin.

1989 • 11 citations

Vasodilator effects of sarafotoxins and endothelin-1 in spontaneously hypertensive rats and rat isolated perfused mesentery

1990 • 10 citations

Endothelin in perinatal pharmacology.

1991 • 10 citations

Involvement of the microtubular system in the endothelin-1 secretion from porcine aortic endothelial cells.

1991 • 1 citations

Conversion of big endothelin-1 to endothelin-1 occurs intracellularly and is inhibited by phosphoramidon in bovine cultured endothelial cells.

1991 • 1 citations