Hepatic effects of endothelin. Receptor characterization and endothelin-induced signal transduction in hepatocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Molecular biology and biochemistry of the endothelins

1989 • 620 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

Receptor-mediated endocytosis

1985 • 577 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Elevated plasma endothelin in patients with diabetes mellitus

1990 • 492 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

The Liver: Biology and Pathobiology

1989 • 293 citations

Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs

1988 • 279 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

1981 • 236 citations

Endothelins ¹

1991 • 213 citations

Two distinct types of endothelin receptors are present on chick cardiac membranes

1989 • 176 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Endothelin, a potent peptide agonist in the liver.

1990 • 161 citations

Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion.

1989 • 160 citations

Heterogeneity of cell surface endothelin receptors.

1990 • 159 citations

Internalization and degradation of receptor-bound human choriogonadotropin in Leydig tumor cells. Fate of the hormone subunits.

1982 • 155 citations

The Fate of Radioiodinated Endothelin-1 and Endothelin-3 in the Rat

1989 • 149 citations

Separation of multiple isomers of inositol phosphates formed in GH3 cells

1987 • 138 citations

Two different forms of endothelin receptors in rat lung

1989 • 117 citations

Elimination of Intravenously Injected Endothelin-1 from the Circulation of the Rat

1989 • 112 citations

Endothelin action in rat liver. Receptors, free Ca2+ oscillations, and activation of glycogenolysis.

1991 • 110 citations

ELEVATION OF PLASMA ENDOTHELIN ASSOCIATED WITH SYSTEMIC HYPERTENSION IN HUMANS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION

1991 • 106 citations

Specific binding of endothelin on human vascular smooth muscle cells in culture.

1989 • 103 citations

Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock

1989 • 102 citations

The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol

1989 • 102 citations

Synthesis of the vasoconstrictor peptide endothelin in kidney cells

1989 • 99 citations

Endothelin in Renal Failure

1990 • 88 citations

Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells

1989 • 86 citations

Specific receptors for endothelin on membranes from human placenta. Characterization and use in a binding assay

1989 • 82 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Sinusoidal endothelial liver cells in vitro release endothelin — Augmentation by transforming growth factorβ and Kupffer cell-conditioned media

1991 • 79 citations

Identification and characterization of endothelin binding sites in rat renal papillary and glomerular membranes

1989 • 78 citations

Endothelin: presence in human umbilical vessels, high levels in fetal blood and potent constrictor effect

1989 • 77 citations

Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.

1990 • 69 citations

Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line.

1988 • 66 citations

A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells

1992 • 64 citations

The effect of acetylglyceryl ether phosphorylcholine on glycogenolysis and phosphatidylinositol 4,5-bisphosphate metabolism in rat hepatocytes.

1984 • 60 citations

Binding Sites for Endothelin-1 in Rat Tissues

1989 • 57 citations

Internalization of endothelin by cultured human vascular smooth muscle cells: characterization and physiological significance.

1990 • 57 citations

Regional distribution of immunoreactive endothelin in rats

1989 • 51 citations

Solubilization and identification of human placental endothelin receptor

1989 • 47 citations

Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

1989 • 34 citations

Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells.

1990 • 33 citations

Plasma-Endothelin bei Normalpersonen und Patienten mit nephrologisch-rheumatologischen und kardiovaskulären Erkrankungen

1990 • 31 citations

PAF effects on transmembrane signaling pathways in rat kupffer cells

1991 • 13 citations