The IRS-signalling system during insulin and cytokine action

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

1996 • 596 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Cross-talk between the insulin and angiotensin signaling systems.

1996 • 410 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice

1996 • 289 citations

Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

1995 • 286 citations

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

1996 • 255 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.

1996 • 232 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins

1995 • 222 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1

1995 • 216 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells

1994 • 196 citations

Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591–786

1996 • 194 citations

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1996 • 193 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

1994 • 170 citations

The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1

1996 • 167 citations

Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases

1995 • 150 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary Adipocytes

1995 • 134 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action

1997 • 130 citations

Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

1996 • 129 citations

The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation

1996 • 127 citations

The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of Insulin Receptor Substrate 2

1996 • 126 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

How Cells Absorb Glucose

1992 • 120 citations

Upstream Mechanisms of Glycogen Synthase Activation by Insulin and Insulin-like Growth Factor-I

1995 • 107 citations

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

1993 • 100 citations

YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites

1996 • 91 citations

Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction

1996 • 90 citations

Transforming potential of the insulin receptor substrate 1.

1995 • 89 citations

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis

1996 • 88 citations

Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1

1995 • 86 citations

The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

1996 • 84 citations

Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen

1995 • 83 citations

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

1993 • 80 citations

Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart

1995 • 80 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-Kinase Activity via Modulation of Phosphorylation of Insulin Receptor Substrate-1

1996 • 49 citations

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

1994 • 48 citations

Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells

1992 • 40 citations

The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction

1995 • 39 citations

Signal transduction in the early Drosophila embryo: when genetics meets biochemistry

1994 • 27 citations

Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY Motif

1995 • 27 citations

Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization

1993 • 26 citations

Gene regulation by IGF‐I

1993 • 8 citations