Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

After Insulin Binds

1987 • 687 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

A procedure for measurement of distribution spaces in isolated fat cells

1972 • 366 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.

1993 • 220 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

1974 • 209 citations

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

1991 • 198 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.

1993 • 160 citations

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

1987 • 156 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

1992 • 148 citations

Effects of Insulin on the Levels of Adenosine 3′:5′-Monophosphate and Lipolysis in Isolated Rat Epididymal Fat Cells

1973 • 144 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes

1992 • 133 citations

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

1992 • 125 citations

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1993 • 120 citations

Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.

1993 • 105 citations

Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase.

1992 • 95 citations

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

1991 • 67 citations

Phosphorylation of the Insulin Receptor in Permeabilized Adipocytes Is Coupled to a Rapid Dephosphorylation Reaction

1989 • 67 citations

Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors.

1989 • 59 citations

The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase

1991 • 58 citations

Insulin Stimulates Phosphatidylinositol‐3‐Kinase activity in rat adipocytes

1992 • 55 citations

A cytosolic protein tyrosine kinase in rat adipocytes

1992 • 54 citations

Mutations in the Juxtamembrane Region of the Insulin Receptor Impair Activation of Phosphatidylinositol 3-Kinase by Insulin

1991 • 49 citations

Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes.

1993 • 29 citations

[85] Insulin receptors

1974 • 29 citations

Differential role of insulin receptor autophosphorylation sites 1162 and 1163 in the long-term insulin stimulation of glucose transport, glycogenesis, and protein synthesis.

1992 • 20 citations