The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

1988 • 934 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

The when and how of Src regulation

1993 • 543 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Initial events of myelination involve Fyn tyrosine kinase signalling

1994 • 383 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

The IRS-1 signaling system

1994 • 310 citations

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1993 • 283 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

1993 • 207 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

1992 • 191 citations

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

1992 • 179 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

1992 • 170 citations

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells

1995 • 145 citations

A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice

1993 • 144 citations

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

1993 • 132 citations

Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.

1993 • 115 citations

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor

1993 • 106 citations

The IRS-1 signaling system

1994 • 95 citations

Association of Fyn with the activated platelet-derived growth factor receptor: requirements for binding and phosphorylation.

1992 • 87 citations

Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen

1995 • 83 citations

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

1992 • 82 citations

Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.

1993 • 80 citations

Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells

1989 • 72 citations

New frontiers in insulin receptor substrate signaling

1995 • 60 citations

Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.

1992 • 57 citations

Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen

1991 • 39 citations

Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases.

1991 • 25 citations

Characterization of the interleukin 4 receptor. Structure and signal transduction pathways

1993 • 7 citations