Association of Insulin Receptor Substrate 1 with Simian Virus 40 Large T Antigen

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

1993 • 452 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc

1994 • 193 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1993 • 170 citations

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

1994 • 170 citations

Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture

1992 • 170 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

1994 • 153 citations

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

1988 • 146 citations

Competition for Overlapping Sites in the Regulatory Region of the Drosophila Gene Krüppel

1992 • 145 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent.

1989 • 103 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

Interference of the IGF system as a strategy to inhibit breast cancer growth

1992 • 100 citations

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor.

1992 • 99 citations

Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen

1992 • 98 citations

Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated large T antigens

1990 • 95 citations

Insulin‐like growth factor I receptor is required for the mitogenic and transforming activities of the platelet‐derived growth factor receptor

1995 • 93 citations

Transforming potential of the insulin receptor substrate 1.

1995 • 89 citations

Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cells

1994 • 87 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

The Erythropoietin Receptor Transmembrane Region Is Necessary for Activation by the Friend Spleen Focus-Forming Virus gp55 Glycoprotein

1992 • 74 citations

Molecular cloning of gene sequences that are regulated by insulin-like growth factor I.

1987 • 71 citations

Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein.

1993 • 70 citations

Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.

1994 • 69 citations

Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.

1985 • 69 citations

Structure and function of SV40 large-T antigen

1987 • 63 citations

Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein

1992 • 62 citations

Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene.

1990 • 52 citations

The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: Identification by cloning

1993 • 51 citations

Enhancement or Inhibition of Insulin Signaling by Insulin Receptor Substrate 1 Is Cell Context Dependent

1994 • 48 citations

Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells.

1995 • 47 citations

Nonviable mutants of simian virus 40 with deletions near the 3' end of gene A define a function for large T antigen required after onset of viral DNA replication

1983 • 45 citations

Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts

1991 • 43 citations

Platelet-derived growth factor-induced expression of messenger RNA for the proliferating cell nuclear antigen requires a functional receptor for the insulin-like growth factor I.

1994 • 32 citations

Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.

1994 • 26 citations

Detection of a complex of SV40 large tumor antigen and 53K cellular protein on the surface of SV40‐transformed mouse cells

1982 • 23 citations

Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells.

1991 • 17 citations

Cooperativity of SV40 T antigen and ras in progressive stages of transformation of human fibroblasts

1992 • 11 citations

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