Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

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Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

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Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

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Neurotrophin-regulated signalling pathways

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Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

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Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

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Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

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The yin and yang of neurotrophin action

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Stress and cognition: are corticosteroids good or bad guys?

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AMPK and PPARδ Agonists Are Exercise Mimetics

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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

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Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

2002 • 932 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

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BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

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Potential therapeutic uses of BDNF in neurological and psychiatric disorders

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BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

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Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

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A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

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Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

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The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

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Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

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Brain-derived neurotrophic factor is reduced in Alzheimer's disease

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Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

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Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

2000 • 538 citations

BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory Synapses

2001 • 506 citations

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

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Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function

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Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

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Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

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NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

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Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

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Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein andFmr1mRNA Localization Differentially in Dendrites and at Synapses

2004 • 378 citations

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

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Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly

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Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

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Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

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Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

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Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone

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Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

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Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition

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Effects of Exercise on Gene-Expression Profile in the Rat Hippocampus

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Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

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Environment Influences Functional Outcome of Cerebral Infarction in Rats

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Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease

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Effects of chronic stress on hippocampal long‐term potentiation

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Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice

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Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain

1997 • 296 citations

Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

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Phosphorylation of cAMP Response Element-Binding Protein in Hippocampal Neurons as a Protective Response after Exposure to GlutamateIn Vitroand IschemiaIn Vivo

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7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

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Age and energy intake interact to modify cell stress pathways and stroke outcome

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I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat

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The exercise-induced expression of BDNF within the hippocampus varies across life-span

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The Effects of Voluntary, Involuntary, and Forced Exercises on Brain-Derived Neurotrophic Factor and Motor Function Recovery: A Rat Brain Ischemia Model

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Sequential mRNA Expression for Immediate Early Genes, Cytokines, and Neurotrophins in Spinal Cord Injury

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Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction

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Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

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BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons

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Down regulation of trk but not p75^NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

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Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons

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Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

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Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?

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Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus

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Identification ofcis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of HumanBDNFGene

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Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?

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Support for a Bimodal Role for Type II Adrenal Steroid Receptors in Spatial Memory

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Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

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Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle

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Expression of BDNF and trkB as a function of age and cognitive performance

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Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats

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Hippocampal Brain-Derived Neurotrophic Factor Expression Following Treatment with Reboxetine, Citalopram, and Physical Exercise

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Interactions between entorhinal axons and target hippocampal neurons: A role for glutamate in the development of hippocampal circuitry

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Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

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Calcium as a modulator of the immediate-early gene cascade in neurons

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Protein Synthesis-dependent and -independent Regulation of Hippocampal Synapses by Brain-derived Neurotrophic Factor

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TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses

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Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia

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Serum BDNF, TNF-α and IL-1β levels in dementia patients

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Dose-Related Effects of Chronic Antidepressants on Neuroprotective Proteins BDNF, Bcl-2 and Cu/Zn-SOD in Rat Hippocampus

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Intermittent Food Deprivation Improves Cardiovascular and Neuroendocrine Responses to Stress in Rats

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Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress‐induced decrease in cell proliferation and BDNF expression in rat hippocampus

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Glucocorticoid Physiology, Pharmacology and Stress

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NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons

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The excitoprotective effect of N‐methyl‐<scp>d</scp>‐aspartate receptors is mediated by a brain‐derived neurotrophic factor autocrine loop in cultured hippocampal neurons

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Voluntary Exercise Impacts on the Rat Hypothalamic-Pituitary-Adrenocortical Axis Mainly at the Adrenal Level

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Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity

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A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome

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Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

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Chronic social stress during adolescence induces cognitive impairment in aged mice

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Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice

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Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations

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BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

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Evidence for Neuroprotective Effects of Endogenous Brain-Derived Neurotrophic Factor after Global Forebrain Ischemia in Rats

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Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF

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Neural Activity and Survival in the Developing Nervous System

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The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA

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Survival effects of BDNF and NT‐3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration

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The glucocorticoid paradox of caloric restriction in slowing brain aging

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Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLCγ1, and ERK in Hippocampal Synaptoneurosomes

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Brain-Derived Neurotrophic Factor Activation of CaM-Kinase Kinase via Transient Receptor Potential Canonical Channels Induces the Translation and Synaptic Incorporation of GluA1-Containing Calcium-Permeable AMPA Receptors

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Dietary restriction started after spinal cord injury improves functional recovery

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Signaling Pathways in Brain Involved in Predisposition and Pathogenesis of Stress‐Related Disease: Genetic and Kinetic Factors Affecting the MR/GR Balance

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Glucocorticoid Prevents Brain-Derived Neurotrophic Factor-Mediated Maturation of Synaptic Function in Developing Hippocampal Neurons through Reduction in the Activity of Mitogen-Activated Protein Kinase

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Regulation of dendritic development by calcium signaling

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Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury

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7,8‐dihydroxyflavone, a TrkB receptor agonist, blocks long‐term spatial memory impairment caused by immobilization stress in rats

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Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender

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Corticosterone Actions on the Hippocampal Brain‐Derived Neurotrophic Factor Expression are Mediated by Exon IV Promoter

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Nature vs. nurture: Can enrichment rescue the behavioural phenotype of BDNF heterozygous mice?

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BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

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Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

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Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity

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Neurons Efficiently Repair Glutamate-induced Oxidative DNA Damage by a Process Involving CREB-mediated Up-regulation of Apurinic Endonuclease 1

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Brain‐derived neurotrophic factor‐mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways

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Paroxetine retards disease onset and progression in Huntingtin mutant mice

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AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated kinase to upregulate BDNF gene expression

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Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

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Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli

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Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice

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Postsynaptic BDNF signalling regulates long‐term potentiation at thalamo‐amygdala afferents

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c-fosReduces Corticosterone-Mediated Effects on Neurotrophic Factor Expression in the Rat Hippocampal CA1 Region

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Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression

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Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells

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BDNF Facilitates L-LTP Maintenance in the Absence of Protein Synthesis through PKMζ

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Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivo

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Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities

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Effects of High-Intensity Isokinetic Exercise on Salivary Cortisol in Athletes with Different Training Schedules: Relationships to Serum Cortisol and Lactate

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Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury

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Prefrontal cortex, caloric restriction and stress during aging: Studies on dopamine and acetylcholine release, BDNF and working memory

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Distinct, Time-Dependent Effects of Voluntary Exercise on Circadian and Ultradian Rhythms and Stress Responses of Free Corticosterone in the Rat Hippocampus

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Essential Role for Vav Guanine Nucleotide Exchange Factors in Brain-Derived Neurotrophic Factor-Induced Dendritic Spine Growth and Synapse Plasticity

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Glucocorticoid Receptor mRNA Expression in the Hippocampal Formation of Male Rats before and after Pubertal Development in Response to Acute or Repeated Stress

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Brain‐derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus‐1 glycoprotein 120 in vivo

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Dietary Restriction Selectively Decreases Glucocorticoid Receptor Expression in the Hippocampus and Cerebral Cortex of Rats

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Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge

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