Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

Mammalian Neural Stem Cells

2000 • 4,689 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

The efficiency of systematic sampling in stereology and its prediction*

1987 • 3,508 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Functional neurogenesis in the adult hippocampus

2002 • 2,813 citations

Neurogenesis in the adult is involved in the formation of trace memories

2001 • 2,014 citations

Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

1997 • 1,880 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

1997 • 1,093 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

New stereological methods for counting neurons

1993 • 951 citations

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory

1999 • 840 citations

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

1999 • 825 citations

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

1997 • 789 citations

BDNF regulates eating behavior and locomotor activity in mice

2000 • 788 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis.

2002 • 720 citations

Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation ofArcSynthesis

2002 • 638 citations

Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

2000 • 538 citations

Regulation of neurogenesis by growth factors and neurotransmitters

1998 • 483 citations

Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation

2002 • 455 citations

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

2002 • 449 citations

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

1999 • 415 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat

1997 • 409 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Dietary Restriction Increases the Number of Newly Generated Neural Cells, and Induces BDNF Expression, in the Dentate Gyrus of Rats

2000 • 396 citations

Dietary restriction and 2‐deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

1999 • 385 citations

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: Evidence for a preconditioning mechanism

1999 • 354 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

1993 • 333 citations

Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice

1997 • 217 citations

Neurotrophin Regulation of the Developing Nervous System: Analyses of Knockout Mice

1997 • 192 citations

Autocrine—paracrine Regulation of Hippocampal Neuron Survival by IGF‐1 and the Neurotrophins BDNF, NT‐3 and NT‐4

1996 • 182 citations

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

2001 • 180 citations

Brain-Derived Neurotrophic Factor-Mediated Protection of Striatal Neurons in an Excitotoxic Rat Model of Huntington's Disease, as Demonstrated by Adenoviral Gene Transfer

1999 • 164 citations

Differential Effects of Intermittent Feeding and Voluntary Exercise on Body Weight and Lifespan in Adult Rats

1983 • 153 citations

Embryonic Precursor Cells That Express Trk Receptors: Induction of Different Cell Fates by NGF, BDNF, NT-3, and CNTF

1997 • 127 citations

Cell death in regenerating populations of neurons in BDNF mutant mice

2000 • 124 citations

Grafting neural stem cells improved the impaired spatial recognition in ischemic rats

2001 • 103 citations

Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons

1995 • 100 citations

Stereological estimation of total microglia number in mouse hippocampus

1998 • 84 citations

Alterations in Nigrostriatal Dopaminergic Function within BDNF Mutant Mice

1999 • 64 citations

Conditionally immortal neuroepithelial stem cell grafts reverse age-associated memory impairments in rats

2000 • 50 citations

Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor

2000 • 37 citations

Correlated long-term increase of brain-derived neurotrophic factor and Trk B proteins in enlarged granule cells of mouse hippocampus after kainic acid injection

1998 • 23 citations