Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

2005 • 1,906 citations

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

2007 • 1,795 citations

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

1998 • 1,795 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

2005 • 1,206 citations

Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

2007 • 1,121 citations

A microfluidic culture platform for CNS axonal injury, regeneration and transport

2005 • 1,093 citations

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

2004 • 1,045 citations

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

2009 • 956 citations

Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury

2003 • 849 citations

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

2007 • 719 citations

The therapeutic potential of neural stem cells

2006 • 717 citations

Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories

2007 • 650 citations

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

2005 • 649 citations

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway

2004 • 416 citations

Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells

2007 • 345 citations

PET amyloid ligand [ ¹¹ C]PIB uptake is increased in mild cognitive impairment

2007 • 320 citations

Stage-dependent BDNF serum concentrations in Alzheimer’s disease

2005 • 312 citations

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease

2007 • 286 citations

Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles

2006 • 272 citations

Gene therapy: can neural stem cells deliver?

2005 • 272 citations

Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells

2007 • 176 citations

Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic–ischemic brain injury

2006 • 171 citations

Neural Stem Cells Improve Memory in an Inducible Mouse Model of Neuronal Loss

2007 • 156 citations

Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease

2007 • 153 citations

BDNF, NT-3, and NGF Released From Transplanted Neural Progenitor Cells Promote Corticospinal Axon Growth in Organotypic Cocultures

2007 • 140 citations

Amyloid-Beta Immunotherapy for the Prevention and Treatment of Alzheimer Disease: Lessons from Mice, Monkeys, and Humans

2006 • 70 citations

Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice

2003 • 48 citations