Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

The molecular neurobiology of depression

2008 • 2,600 citations

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Neurotrophin signal transduction in the nervous system

2000 • 1,910 citations

Virtual screening of chemical libraries

2004 • 1,314 citations

Ageing and neuronal vulnerability

2006 • 1,009 citations

Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus

2005 • 741 citations

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

2008 • 607 citations

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF

1996 • 583 citations

Role of brain-derived neurotrophic factor in Huntington's disease

2007 • 518 citations

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

2008 • 383 citations

Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISAIn Situ

2000 • 333 citations

Neurotrophic factors in Alzheimer’s disease: role of axonal transport

2008 • 331 citations

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

2008 • 298 citations

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

2007 • 295 citations

NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

2000 • 287 citations

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

2007 • 285 citations

Effect of Brain-Derived Neurotrophic Factor Treatment and Forced Arm Use on Functional Motor Recovery After Small Cortical Ischemia

2004 • 276 citations

Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation

2009 • 271 citations

Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection

1993 • 254 citations

Brain-Derived Neurotrophic Factor Expression and Respiratory Function Improve after Ampakine Treatment in a Mouse Model of Rett Syndrome

2007 • 236 citations

Differential Targeting of Gßγ-Subunit Signaling with Small Molecules

2006 • 227 citations

Short and long-term motor skill learning in an accelerated rotarod training paradigm

2004 • 201 citations

Point Mutation in trkB Causes Loss of NT4-Dependent Neurons without Major Effects on Diverse BDNF Responses

1998 • 199 citations

Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise

2004 • 196 citations

Autocrine—paracrine Regulation of Hippocampal Neuron Survival by IGF‐1 and the Neurotrophins BDNF, NT‐3 and NT‐4

1996 • 182 citations

AAV-Mediated gene delivery of BDNF or GDNF is neuroprotective in a model of huntington disease

2004 • 163 citations

Blood–brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion

2006 • 160 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway

2001 • 148 citations

Small, Nonpeptide p75^NTRLigands Induce Survival Signaling and Inhibit proNGF-Induced Death

2006 • 145 citations

Hot-spot mimicry of a cytokine receptor by a small molecule

2006 • 140 citations

Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease

2006 • 126 citations

Design of Potent Peptide Mimetics of Brain-derived Neurotrophic Factor

2003 • 126 citations

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

2008 • 122 citations

Structure of the Brain-Derived Neurotrophic Factor/Neurotrophin 3 Heterodimer

1995 • 120 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

A mouse model of sensorimotor controlled cortical impact: Characterization using longitudinal magnetic resonance imaging, behavioral assessments and histology

2006 • 101 citations

Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities

2000 • 100 citations

K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK

2002 • 100 citations

TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice

2007 • 80 citations

Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits

2000 • 80 citations

High Affinity Not in the Vicinity?

2007 • 80 citations

Plate-Based Diversity Selection Based on Empirical HTS Data to Enhance the Number of Hits and Their Chemical Diversity

2009 • 77 citations

Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-κB

2002 • 76 citations

LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways

2006 • 60 citations

Involvement of dopamine D2/D3 receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells

2004 • 58 citations

Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action

2000 • 58 citations

Brain‐derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway

2008 • 58 citations

Nasal insulin gel as an alternate to parenteral insulin: Formulation, preclinical, and clinical studies

2005 • 56 citations

Tool-use learning induces BDNF expression in a selective portion of monkey anterior parietal cortex

2002 • 55 citations

Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth

2003 • 53 citations

A New Device for Experimental Modeling of Central Nervous System Injuries

2005 • 51 citations

Controlled contusion injury alters molecular systems associated with cognitive performance

2008 • 50 citations

Nerve Growth Factor Signals via Preexisting TrkA Receptor Oligomers

2002 • 49 citations

Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor

2006 • 44 citations

BDNF increases homotypic olivocerebellar reinnervation and associated fine motor and cognitive skill

2008 • 42 citations

IGF‐1 and bFGF reduce glutaric acid and 3‐hydroxyglutaric acid toxicity in striatal cultures

2001 • 42 citations

Overcoming the Inhibitors of Myelin with a Novel Neurotrophin Strategy

2004 • 32 citations

High-Potency Olfactory Receptor Agonists Discovered by Virtual High-Throughput Screening: Molecular Probes for Receptor Structure and Olfactory Function

2008 • 27 citations

TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice.

2008 • 22 citations

Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC

2001 • 15 citations