Sequential mRNA Expression for Immediate Early Genes, Cytokines, and Neurotrophins in Spinal Cord Injury

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

A Complete Protocol forIn SituHybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

1989 • 883 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data

1992 • 716 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury

1997 • 620 citations

Neurotrophins and brain insults

1994 • 564 citations

The p75 neurotrophin receptor

1994 • 480 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

A Complete Protocol for <I>In Situ</I> Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

1989 • 449 citations

Interleukin-1 and Tumor Necrosis Factor-α Synergistically Mediate Neurotoxicity: Involvement of Nitric Oxide and of N-Methyl-D-aspartate Receptors

1995 • 409 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

1990 • 314 citations

Cytokines and the nervous system I: expression and recognition

1995 • 307 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

1995 • 300 citations

Induction of interleukin-6 in axotomized sensory neurons

1995 • 273 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines

1992 • 207 citations

TNFα induces IL-6 production by astrocytes but not by microglia

1992 • 185 citations

Hypoxic-Ischemic Brain Injury Induces an Acute Microglial Reaction in Perinatal Rats1

1996 • 158 citations

Production of tumor necrosis factor in spinal cord following traumatic injury in rats

1996 • 153 citations

Systemic interleukin-1β decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation

1993 • 143 citations

Role of Lipid Peroxidation in Post-Traumatic Spinal Cord Degeneration: A Review

1986 • 141 citations

Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic fgf elicit differential responses in the adult spinal cord

1996 • 140 citations

Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord.

1992 • 131 citations

Role of primary response genes in generating cellular responses to growth factors

1992 • 124 citations

Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury

1994 • 120 citations

Immediate-early genes, neuronal plasticity, and memory

1992 • 110 citations

Spinal Cord Injury in the Rat: Treatment with Bacterial Lipopolysaccharide and Indomethacin Enhances Cellular Repair and Locomotor Function

1994 • 108 citations

Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain.

1997 • 102 citations

Altered Immunoexpression of Microglia and Macrophages after Mild Head Injury

1995 • 96 citations

▪ Spinal Cord Injury: Role of Steroid Therapy

1994 • 86 citations

Effect of tumor necrosis factor α and β on human oligodendrocytes and neurons in culture

1995 • 71 citations

Neuroprotective effect of various cytokines on developing spinal motoneurons following axotomy

1996 • 69 citations

Is IL-6 both a cytokine and a neurotrophic factor?

1996 • 64 citations

Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease

1996 • 63 citations

Transcriptional and Posttranscriptional Mechanisms Involved in the Interleukin‐1, Steroid, and Protein Kinase C Regulation of Nerve Growth Factor in Cortical Astrocytes

1994 • 53 citations

Gene Expression of Neurotrophins and Their Receptors in Cultured Rat Vascular Smooth Muscle Cells

1998 • 52 citations

Mechanisms of nerve growth factor mRNA regulation by interleukin‐1β in hippocampal cultures: Role of second messengers

1992 • 47 citations

Protective Effect of Methylprednisolone on Vascular Injury in Rat Spinal Cord Injury

1992 • 42 citations

The effects of glucocorticoid and nonglucocorticoid steroids on acute neuronal degeneration.

1993 • 40 citations

Astrocytic Reaction after Graded Spinal Cord Compression in Rats: Immunohistochemical Studies on Glial Fibrillary Acidic Protein and Vimentin

1995 • 38 citations

Localization of nerve growth factor receptor mRNA in contused rat spinal cord by in situ hybridization

1991 • 25 citations

[Contribution of cytokines to inflammatory mechanisms].

1993 • 23 citations

trk C expression in the injured rat spinal cord

1993 • 22 citations

Tungsten treatment prevents tumor necrosis factor-induced injury of brain endothelial cells

1992 • 22 citations

Cytokine‐induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate

1995 • 18 citations

Circulating Levels of Soluble Interleukin 2 Receptors Are Elevated in the Sera of Humans with Spinal Cord Injury

1993 • 15 citations

Spinal Cord Injury: Are Interleukins a Molecular Link between Neuronal Damage and Ensuing Pathobiology?

1993 • 12 citations

Spinal Cord Transection in Adult Rats

1993 • 7 citations

A possible mechanism of TPA-mediated downregulation of neurotrophin-3 gene expression in rat cultured vascular smooth muscle cells

1999 • 4 citations