Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLCγ1, and ERK in Hippocampal Synaptoneurosomes

Trk Receptors: Roles in Neuronal Signal Transduction

2003 • 2,410 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

Regulation of Cell Survival by Secreted Proneurotrophins

2001 • 1,618 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

2005 • 1,155 citations

Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity

2004 • 1,084 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

BDNF and Activity-Dependent Synaptic Modulation: Figure 1.

2003 • 906 citations

From Acquisition to Consolidation: On the Role of Brain-Derived Neurotrophic Factor Signaling in Hippocampal-Dependent Learning

2002 • 667 citations

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

2009 • 567 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain

1978 • 464 citations

BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

2004 • 399 citations

Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

2004 • 318 citations

Peripheral infection and aging interact to impair hippocampal memory consolidation

2006 • 315 citations

Early events in neurotrophin signalling via Trk and p75 receptors

1995 • 314 citations

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

2009 • 250 citations

Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist

2003 • 240 citations

Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus

2001 • 239 citations

Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats

2005 • 223 citations

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

2008 • 214 citations

Cognitive function after anaesthesia in the elderly

2003 • 208 citations

BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration

2004 • 187 citations

Thirty years of synaptosome research

1993 • 173 citations

Systemic interleukin-1β decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation

1993 • 143 citations

Proteolysis of proBDNF Is a Key Regulator in the Formation of Memory

2008 • 112 citations

Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain

2007 • 105 citations

Differential effects of everyday stress on the episodic memory test performances of young, mid-life, and older adults

2005 • 104 citations

Whither proBDNF?

2009 • 93 citations

Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats

2007 • 89 citations

Acute cognitive impairment in elderly ED patients: Etiologies and outcomes

1996 • 81 citations

IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344×BN F1 rats

2009 • 78 citations

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

2010 • 66 citations

Characterization of the sickness response in young and aging rats following E. coli infection

2009 • 62 citations

Effect of Aging on Brain-Derived Neurotrophic Factor, proBDNF, and Their Receptors in the Hippocampus of Lou/C Rats

2008 • 30 citations