Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Mild cognitive impairment as a diagnostic entity

2004 • 7,048 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment

2002 • 1,912 citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

2004 • 1,637 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Depression and Risk for Alzheimer Disease

2006 • 1,348 citations

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

2000 • 1,259 citations

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

2005 • 1,206 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

2003 • 933 citations

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

2004 • 928 citations

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

2003 • 928 citations

Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety

2000 • 927 citations

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

2004 • 893 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

2005 • 859 citations

Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

2003 • 811 citations

Essential Role for TrkB Receptors in Hippocampus-Mediated Learning

1999 • 797 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces

2004 • 674 citations

The Use of the Morris Water Maze in the Study of Memory and Learning

1989 • 665 citations

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

2005 • 649 citations

Positron emission tomography in Alzheimer's disease

1986 • 563 citations

E<scp>PIDEMIOLOGY OF</scp>N<scp>EURODEGENERATION</scp>

2003 • 513 citations

Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

2002 • 508 citations

cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment

2000 • 503 citations

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

2000 • 499 citations

Serotonin in Aging, Late-Life Depression, and Alzheimer's Disease: The Emerging Role of Functional Imaging

1998 • 493 citations

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

1995 • 488 citations

Acetylcholine modulation of neural systems involved in learning and memory

2003 • 440 citations

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 • 423 citations

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2003 • 417 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

BDNF and Full-length and Truncated TrkB Expression in Alzheimer Disease. Implications in Therapeutic Strategies

1999 • 387 citations

Cortical abnormalities in Alzheimer's disease

1984 • 378 citations

Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease

2005 • 370 citations

New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry

1998 • 364 citations

Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

2004 • 318 citations

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

2004 • 318 citations

Hippocampal innervation by serotonin neurons of the midbrain raphe in the rat

1975 • 310 citations

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

2005 • 306 citations

Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

2000 • 292 citations

Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice

2003 • 282 citations

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

1995 • 281 citations

Fluoxetine Versus Sertraline and Paroxetine in Major Depressive Disorder

2000 • 259 citations

Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors

2004 • 256 citations

Bi-phasic change in BDNF gene expression following antidepressant drug treatment

2003 • 244 citations

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

2001 • 229 citations

Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?

1998 • 228 citations

Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

2001 • 224 citations

Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 221 citations

β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised

2001 • 211 citations

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

2001 • 199 citations

Emotional Memory: In Search of Systems and Synapses^a

1993 • 189 citations

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

2003 • 179 citations

Tau gene mutations: dissecting the pathogenesis of FTDP-17

2002 • 174 citations

Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

2001 • 162 citations

Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant

2003 • 157 citations

Mechanism of Cerebral β-Amyloid Angiopathy: Murine and Cellular Models

2006 • 148 citations

Influence of Paroxetine, Branched-Chain Amino Acids and Tyrosine on Neuroendocrine System Responses and Fatigue in Humans

1998 • 140 citations

Amygdala Volume Reductions in Pediatric Patients with Obsessive–Compulsive Disorder Treated with Paroxetine: Preliminary Findings

2004 • 140 citations

Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety

2004 • 129 citations

Does my mouse have Alzheimer's disease?

2002 • 129 citations

Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms

2005 • 121 citations

Estrogen induces a rapid secretion of amyloid β precursor protein via the mitogen‐activated protein kinase pathway

2001 • 118 citations

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

1991 • 116 citations

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels

2006 • 112 citations

Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease

1994 • 111 citations

Interactions of Amyloidogenic Proteins

2003 • 111 citations

Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders

2003 • 110 citations

Quality of life and metabolic status in mildly depressed women with type 2 diabetes treated with paroxetine: A single-blind randomised placebo controlled trial

2003 • 105 citations

The mechanisms involved in the long‐lasting neuroprotective effect of fluoxetine against MDMA (‘ecstasy’)‐induced degeneration of 5‐HT nerve endings in rat brain

2001 • 105 citations

Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus

2002 • 103 citations

Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats

1999 • 96 citations

Amygdala cell loss and atrophy in Alzheimer's disease

1992 • 94 citations

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer β-amyloid pathology

2006 • 94 citations

Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment

2005 • 92 citations

Paroxetine retards disease onset and progression in Huntingtin mutant mice

2004 • 91 citations

Development of Aβ terminal end-specific antibodies and sensitive ELISA for Aβ variant

2004 • 81 citations

Sex differences in serotonergic activity in dorsal and median raphe nucleus

2003 • 70 citations

Functional Neurochemistry of Alzheimers Disease

2004 • 65 citations

Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients

2005 • 62 citations

Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine

2002 • 62 citations

GABA-A and 5-HT1A Receptor Agonists Block Expression of Fear-Potentiated Startle in Mice

2002 • 57 citations

Affinity Purification of Human τ Proteins and the Construction of a Sensitive Sandwich Enzyme‐Linked Immunosorbent Assay for Human τ Detection

1992 • 48 citations

FDA-Preapproved Drugs Targeted to the Translational Regulation and Processing of the Amyloid Precursor Protein

2004 • 46 citations

Disturbance of the 5-hydroxytryptamine metabolism in brains from patients with Alzheimer’s dementia

1990 • 42 citations

Pilot Study of the Reducing Effect on Amyloidosis In Vivo by Three FDA Pre-Approved Drugs Via the Alzheimers APP 5Untranslated Region

2005 • 41 citations

Toward Alzheimer Therapies Based on Genetic Knowledge

2004 • 40 citations

Spotlight on Paroxetine in Psychiatric Disorders in Adults*

2002 • 31 citations

Restraint stress induces β-amyloid precursor protein mRNA expression in the rat basolateral amygdala

2004 • 25 citations

Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats

2004 • 25 citations

Evaluation of [³H]paroxetine as an in vivo ligand for serotonin uptake sites: A quantitative autoradiographic study in the rat brain

1993 • 24 citations

Use of paroxetine for the treatment of depression and anxiety disorders in the elderly: a review

2002 • 23 citations

Influence of fluoxetine and paroxetine in behavioral sensitization induced by ethanol in mice

2005 • 20 citations

The amygdala in down's syndrome and familial Alzheimer's disease: Four clinicopathological case report

1991 • 19 citations

Laterality in the Histological Effects of Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats

1997 • 17 citations

Alzheimer's disease: From molecular biology to neuropsychiatry

2003 • 13 citations

Clinical and Molecular Aspects of Frontotemporal Dementia

2004 • 10 citations

Alzheimer's disease. The density of amygdalar neuritic plaques is associated with the severity of neurofibrillary pathology and the degree of beta-amyloid protein deposition in the cerebral cortex.

1998 • 8 citations