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BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog

Data up to Jan 2025

Published2010
Citations95
References69

Total Citations Per Year

Abstract

References (69)

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

2002 • 2,850 citations

Exercise: a behavioral intervention to enhance brain health and plasticity

2002 • 2,571 citations

Exercise builds brain health: key roles of growth factor cascades and inflammation

2007 • 2,048 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

2005 • 1,155 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

2009 • 956 citations

BDNF and Activity-Dependent Synaptic Modulation: Figure 1.

2003 • 906 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo

2004 • 816 citations

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

2009 • 810 citations

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

2005 • 769 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

2005 • 649 citations

Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

1987 • 472 citations

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

2005 • 455 citations

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

2002 • 449 citations

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

2008 • 409 citations

BDNF and Full-length and Truncated TrkB Expression in Alzheimer Disease. Implications in Therapeutic Strategies

1999 • 387 citations

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

1992 • 386 citations

Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity

2003 • 374 citations

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease

2000 • 316 citations

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

2006 • 283 citations

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

1992 • 281 citations

Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease

2003 • 244 citations

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

1994 • 224 citations

β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine

1996 • 217 citations

β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised

2001 • 211 citations

β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

2004 • 211 citations

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease

2009 • 205 citations

Age-related changes in brain-derived neurotrophic factor and tyrosine kinase receptor isoforms in the hippocampus and hypothalamus in male rats

2005 • 205 citations

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

1994 • 196 citations

Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model

1998 • 191 citations

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

2006 • 191 citations

Oxidative damage increases with age in a canine model of human brain aging

2002 • 191 citations

Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

2001 • 188 citations

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

2004 • 187 citations

β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

1993 • 185 citations

β-Amyloid impairs axonal BDNF retrograde trafficking

2009 • 185 citations

Autocrine—paracrine Regulation of Hippocampal Neuron Survival by IGF‐1 and the Neurotrophins BDNF, NT‐3 and NT‐4

1996 • 182 citations

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

2001 • 180 citations

The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches

2008 • 177 citations

Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells

2007 • 176 citations

Influence of differential housing on emotional behaviour and neurotrophin levels in mice

2006 • 171 citations

Visual-discrimination learning ability and β-amyloid accumulation in the dog

1998 • 170 citations

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

2002 • 170 citations

Dietary enrichment counteracts age-associated cognitive dysfunction in canines

2002 • 146 citations

Region-specific age at onset of β-amyloid in dogs☆

2000 • 146 citations

Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy

2002 • 141 citations

A new brain‐derived neurotrophic factor transcript and decrease inbrain‐derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex

2002 • 138 citations

Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs

2004 • 135 citations

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

2006 • 129 citations

Diffuse plaques contain C-terminal Aβ42 and not Aβ40: Evidence from cats and dogs

1996 • 128 citations

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function

2007 • 127 citations

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

2008 • 126 citations

Behavior Problems in Geriatric Pets

2005 • 125 citations

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

2006 • 108 citations

Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine

2002 • 105 citations

Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging

2009 • 75 citations

Alterations in Trk A, Trk B and Trk C Receptor Immunoreactivities in Parietal Cortex and Cerebellum in Alzheimer’s Disease

2000 • 58 citations

Environmental Enrichment‐Behavior‐Oxidative Stress Interactions in the Aged Rat: Issues for a Therapeutic Approach in Human Aging

2004 • 43 citations

Increased synaptic inhibition in dentate gyrus of mice with reduced levels of endogenous brain-derived neurotrophic factor

2000 • 37 citations

Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks

2004 • 36 citations

Enhanced spatial ability in aged dogs following dietary and behavioural enrichment

2007 • 31 citations

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