The Origins of Diversity and Specificity in G Protein-Coupled Receptor Signaling

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1998 • 2,076 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

β-Arrestin-Dependent Formation of β ₂ Adrenergic Receptor-Src Protein Kinase Complexes

1999 • 1,427 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

2002 • 1,070 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 • 799 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

2003 • 655 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist

1997 • 622 citations

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

1992 • 587 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Emerging Themes in Lipid Rafts and Caveolae

2001 • 567 citations

HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication

1997 • 564 citations

Oligomerization of μ- and δ-Opioid Receptors

2000 • 545 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

2000 • 528 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

2003 • 497 citations

Targeting of Cyclic AMP Degradation to β ₂ -Adrenergic Receptors by β-Arrestins

2002 • 496 citations

Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor

2004 • 487 citations

Dimerization of the δ Opioid Receptor:

1997 • 479 citations

On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine

1967 • 425 citations

The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor

2000 • 411 citations

Dimerization of the Extracellular Calcium-sensing Receptor (CaR) on the Cell Surface of CaR-transfected HEK293 Cells

1998 • 396 citations

β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation

2002 • 386 citations

Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes

2001 • 376 citations

Regulation of Phosphoinositide Phospholipases by Hormones, Neurotransmitters, and Other Agonists Linked to G Proteins

1996 • 362 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

Identification of G protein‐coupled receptor genes from the human genome sequence

2002 • 355 citations

Membrane organization in G‐protein mechanisms

1994 • 345 citations

Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7

2004 • 319 citations

Drug Efficacy at G Protein–Coupled Receptors

2002 • 315 citations

CGRP-RCP, a Novel Protein Required for Signal Transduction at Calcitonin Gene-related Peptide and Adrenomedullin Receptors

2000 • 313 citations

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

1996 • 312 citations

Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

2002 • 310 citations

G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction

2002 • 263 citations

Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors

2002 • 235 citations

Cooperation of Multiple CCR5 Coreceptors Is Required for Infections by Human Immunodeficiency Virus Type 1

2000 • 230 citations

The ‘magic tail’ of G protein‐coupled receptors: an anchorage for functional protein networks

2003 • 228 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor

1997 • 218 citations

μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

1997 • 218 citations

Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi

2002 • 199 citations

Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor.

1997 • 198 citations

Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density.

1994 • 194 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity

1997 • 182 citations

Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity

1995 • 172 citations

Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.

1994 • 171 citations

Evidence for Adenosine/Dopamine Receptor Interactions Indications for Heteromerization

2000 • 169 citations

Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s).

2000 • 158 citations

Gonadotropin-Releasing Hormone (GnRH) Antagonists Promote Proapoptotic Signaling in Peripheral Reproductive Tumor Cells by Activating a Gαi-Coupling State of the Type I GnRH Receptor

2004 • 145 citations

Stimulated D₁ dopamine receptors couple to multiple Gα proteins in different brain regions

2001 • 143 citations

Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains

2003 • 134 citations

Protein Kinase A-mediated Phosphorylation of Serine 357 of the Mouse Prostacyclin Receptor Regulates Its Coupling to Gs-, to Gi-, and to Gq-coupled Effector Signaling

2001 • 119 citations

Adenosine A1 Receptor-mediated Modulation of Dopamine D1 Receptors in Stably Cotransfected Fibroblast Cells

1998 • 113 citations

Effects of Guanine, Inosine, and Xanthine Nucleotides on β₂-Adrenergic Receptor/G_sInteractions: Evidence for Multiple Receptor Conformations

1999 • 109 citations

Specific β ₂ AR Blocker ICI 118,551 Actively Decreases Contraction Through a G _i -Coupled Form of the β ₂ AR in Myocytes From Failing Human Heart

2002 • 108 citations

AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes

2004 • 107 citations

Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK-1 receptors.

1996 • 105 citations

Induction of Promiscuous G Protein Coupling of the Follicle-Stimulating Hormone (FSH) Receptor: A Novel Mechanism for Transducing Pleiotropic Actions of FSH Isoforms

1997 • 105 citations

Expression of the μ‐Opioid Receptor in CHO Cells: Ability of μ‐Opioid Ligands to Promote α‐Azidoanilido[³²P]GTP Labeling of Multiple G Protein α Subunits

1995 • 102 citations

Assembly of a Ca2+-dependent BK channel signaling complex by binding to β2 adrenergic receptor

2004 • 102 citations

The CB(1) cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain.

2000 • 97 citations

Influence of Receptor Number on Functional Responses Elicited by Agonists Acting at the Human Adenosine A₁Receptor: Evidence for Signaling Pathway-Dependent Changes in Agonist Potency and Relative Intrinsic Activity

2000 • 93 citations

Functional Switch from Facilitation to Inhibition in the Control of Glutamate Release by Metabotropic Glutamate Receptors

1998 • 92 citations

Ligand-Induced Phosphorylation, Clustering, and Desensitization of A₁Adenosine Receptors

1997 • 86 citations

On the Application of R-Curves and Maximum Load Toughness to Structures

1988 • 82 citations

Alpha 2-adrenergic receptor stimulation of phospholipase A2 and of adenylate cyclase in transfected Chinese hamster ovary cells is mediated by different mechanisms.

1991 • 80 citations

Pharmacological proteus?

1995 • 80 citations

Inverse agonism: theory and practice

1995 • 80 citations

Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants

1997 • 74 citations

Recent advances in drug action and therapeutics: Relevance of novel concepts in G‐protein‐coupled receptor and signal transduction pharmacology

2004 • 70 citations

G_iActivator Region of α_2A-Adrenergic Receptors: Distinct Basic Residues Mediate G_iversus G_sActivation

1999 • 67 citations

Direct Binding of the β1 Adrenergic Receptor to the Cyclic AMP-Dependent Guanine Nucleotide Exchange Factor CNrasGEF Leads to Ras Activation

2002 • 66 citations

Rapid Desensitization of the Serotonin_2C Receptor System: Effector Pathway and Agonist Dependence

2002 • 61 citations

Mechanisms of Endothelin Receptor Subtype-specific Targeting to Distinct Intracellular Trafficking Pathways

2001 • 55 citations

Bombesin and Substance P Analogues Differentially Regulate G-protein Coupling to the Bombesin Receptor

2001 • 55 citations

Selection of distinct conformational states of the 5‐HT₃ receptor by full and partial agonists

1996 • 54 citations

Further Delineation of the Two Binding Sites (R*n) Associated with Tachykinin Neurokinin-1 Receptors Using [3-Prolinomethionine11]SP Analogues

1999 • 50 citations

The Cholecystokinin_B Receptor Is Coupled to Two Effector Pathways Through Pertussis Toxin‐Sensitive and ‐Insensitive G Proteins

1999 • 49 citations

Targeting G protein-coupled receptor kinases to their receptor substrates

1997 • 47 citations

Role of G-protein availability in differential signaling by alpha 2-adrenoceptors 1 1Abbreviations: α2-AR, α2-adrenergic receptor; AC, adenylyl cyclase; GTPγS, guanosine 5′-O-(3-thiotriphosphate); IBMX, 3-isobutyl-1-methyl-xanthine; UK14,304, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine.

2001 • 44 citations

Compartmentation of Second Messenger Action: Immunocytochemical and Biochemical Evidence

1985 • 38 citations

Induction of Promiscuous G Protein Coupling of the Follicle-Stimulating Hormone (FSH) Receptor: A Novel Mechanism for Transducing Pleiotropic Actions of FSH Isoforms

1997 • 31 citations

Comparative effects of receptor inactivation, 17 beta-estradiol and pertussis toxin on dopaminergic inhibition of prolactin secretion in vitro.

1992 • 31 citations

The relationship between the agonist‐induced activation and desensitization of the human tachykinin NK₂ receptor expressed in Xenopus oocytes

1998 • 19 citations

alpha-2 Adrenergic Receptors

1988 • 17 citations