A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Solid Phase Peptide Synthesis

1976 • 1,798 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Dopamine receptor pharmacology

1994 • 959 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Sequence specificity in the dimerization of transmembrane .alpha.-helixes

1992 • 490 citations

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices.

1992 • 472 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

Membrane organization in G‐protein mechanisms

1994 • 345 citations

Adrenergic Receptors as Models for G Protein-Coupled Receptors

1992 • 340 citations

Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors.

1993 • 321 citations

A dimerization motif for transmembrane α–helices

1994 • 313 citations

How are proteins imported into mitochondria?

1983 • 307 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

1994 • 224 citations

Structure, function, and regulation of adrenergic receptors

1993 • 224 citations

Subunit structure of human erythrocyte glycophorin A

1976 • 222 citations

Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling

1996 • 213 citations

Bacterial Chemotaxis and the Molecular Logic of Intracellular Signal Transduction Networks

1991 • 193 citations

Ligand-induced dimerization of the platelet-derived growth factor receptor

1989 • 190 citations

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

1982 • 183 citations

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor

1994 • 176 citations

Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells.

1992 • 176 citations

Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors

1995 • 172 citations

X-ray diffraction analysis of matrix porin, an integral membrane protein from Escherichia coli outer membranes

1983 • 166 citations

Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.

1981 • 162 citations

Secondary structure and assembly mechanism of an oligomeric channel protein

1985 • 160 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Synthetic Peptides Mimic the Assembly of Transmembrane Glycoproteins

1989 • 155 citations

Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus.

1994 • 149 citations

Human serotonin1B receptor expression in Sf9 cells: Phosphorylation, palmitoylation, and adenylyl cyclase inhibition

1993 • 146 citations

Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation.

1994 • 141 citations

Aspartate receptors of Escherichia coli and Salmonella typhimurium bind ligand with negative and half-of-the-sites cooperativity

1994 • 135 citations

Solid phase peptide synthesis

2022 • 124 citations

Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.

1985 • 113 citations

Phosphorylation and Palmitoylation of the Human D2_L Dopamine Receptor in Sf9 Cells

1994 • 111 citations

Allosteric behavior in transducin activation mediated by rhodopsin. Initial rate analysis of guanine nucleotide exchange.

1987 • 105 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

1994 • 102 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states.

1983 • 100 citations

Interaction between apolipoproteins A-I and A-II and the membrane attack complex of complement. Affinity of the apoproteins for polymeric C9.

1993 • 95 citations

Physical properties of the purified cardiac muscarinic acetylcholine receptor

1986 • 93 citations

Intrasubunit Signal Transduction by the Aspartate Chemoreceptor

1991 • 82 citations

The hepatic glucagon receptor. Solubilization, characterization, and development of an affinity adsorption assay for the soluble receptor.

1984 • 82 citations

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

1988 • 81 citations

Pharmacological proteus?

1995 • 80 citations

Inverse agonism: theory and practice

1995 • 80 citations

C-terminal Truncation of the Neurokinin-2 Receptor Causes Enhanced and Sustained Agonist-induced Signaling

1995 • 76 citations

The Role of GTP-Binding Proteins in Signal Transduction: From the Sublimely Simple to the Conceptually Complex

1992 • 72 citations

Evidence of paired M2 muscarinic receptors.

1991 • 72 citations

Molecular weight of poly(C9). 12 to 18 C9 molecules form the transmembrane channel of complement.

1984 • 69 citations

Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo

1995 • 68 citations

Folding and assembly of phage P22 tailspike endorhamnosidase lacking the N‐terminal, head‐binding domain

1993 • 65 citations

Close association of the alpha subunits of Gq and G11 G proteins with actin filaments in WRK1 cells: relation to G protein-mediated phospholipase C activation.

1995 • 64 citations

Cooperative binding of the retinal rod G-protein, transducin, to light-activated rhodopsin.

1993 • 57 citations

“Frozen” dynamic dimer model for transmembrane signaling in bacterial chemotaxis receptors

1994 • 52 citations

A kinetic model for oxotremorine M binding to recombinant porcine m2 muscarinic receptors expressed in Chinese hamster ovary cells

1994 • 49 citations

In situ cross-linking of human erythrocyte band 3 by bis(sulfosuccinimidyl)suberate. Evidence for ligand modulation of two alternate quaternary forms: covalent band 3 dimers and noncovalent tetramers formed by the association of two covalent dimers.

1990 • 49 citations

Oligomerization of the cytoplasmic fragment from the aspartate receptor of Escherichia coli

1992 • 42 citations

Dopamine D4 receptors: curiouser and curiouser

1994 • 35 citations

Characterization of the Rat m3 Muscarinic Acetylcholine Receptor Produced in Insect Cells Infected with Recombinant Baculovirus

1995 • 31 citations

G protein-linked receptors labeled by [3H]histamine in guinea pig cerebral cortex. II. Mechanistic basis for multiple states of affinity [corrected].

1993 • 26 citations

The structure of α- and β-adrenergic receptors

1983 • 21 citations

Functional Wild-Type and Carboxy-Terminal-Tagged Rat Substance P Receptors Expressed in Baculovirus-Infected Insect Sf9 Cells

1995 • 16 citations

G protein-linked receptors labeled by [3H]histamine in guinea pig cerebral cortex. I. Pharmacological characterization [corrected].

1993 • 16 citations