Protein Kinase A-mediated Phosphorylation of Serine 357 of the Mouse Prostacyclin Receptor Regulates Its Coupling to Gs-, to Gi-, and to Gq-coupled Effector Signaling

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1991 • 1,330 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

G Protein-coupled Receptors

1998 • 1,033 citations

Altered pain perception and inflammatory response in mice lacking prostacyclin receptor

1997 • 775 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.

1991 • 453 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D

1997 • 390 citations

Pharmacodynamic profile of prostacyclin

1995 • 291 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla

1994 • 255 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

Prostacyclin is a specific effector of adipose cell differentiation. Its dual role as a cAMP- and Ca(2+)-elevating agent.

1992 • 167 citations

The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.

1997 • 163 citations

Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.

1994 • 118 citations

7TM receptors: the splicing on the cake

1999 • 118 citations

Focus on prostacyclin and its novel mimetics

1996 • 109 citations

The α, but Not the β, Isoform of the Human Thromboxane A2 Receptor Is a Target for Prostacyclin-mediated Desensitization

2000 • 103 citations

Platelet prostanoid receptors

1996 • 93 citations

Internalization and Sequestration of the Human Prostacyclin Receptor

2000 • 88 citations

The Prostacyclin Receptor Is Isoprenylated

1999 • 78 citations

Phosphorylation of the Prostacyclin Receptor during Homologous Desensitization

1998 • 70 citations

PhosphoBase: a database of phosphorylation sites

1998 • 68 citations

Alternate Coupling of Receptors to Gs and Gi in Pancreatic and Submandibular Gland Cells

1999 • 63 citations

Agonist-dependent Phosphorylation of an Epitope-tagged Human Prostacyclin Receptor

1996 • 61 citations

Cloning and expression of a cDNA for rat prostacyclin receptor

1994 • 57 citations

Tolerance development to antimitogenic actions of prostacyclin but not of prostaglandin E1 in coronary artery smooth muscle cells

1998 • 56 citations

Cytoprotective effect of TRK-100, a prostacyclin analogue, against chemical injuries in cultured human vascular endothelial cells

1990 • 48 citations

Effect of the prostacyclin analogue iloprost on K+ permeability in the smooth muscle cells of the canine carotid artery.

1989 • 42 citations

Internalization and down-regulation of the prostacyclin receptor in human platelets

1997 • 38 citations

Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s

1991 • 38 citations

Desensitization of prostacyclin responsiveness in a neuronal hybrid cell line: selective loss of high affinity receptors

1985 • 38 citations

Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways

1992 • 36 citations

New Trends in Thromboxane and Prostacyclin Modulators

2000 • 34 citations

Differential activation of Gi and GS proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL

1995 • 33 citations

Desensitization of adenylate cyclase responses following exposure to IP prostanoid receptor agonists

1994 • 25 citations

Signal transduction; a practical approach

1993 • 25 citations

Involvement of Phosphatidylcholine‐Specific Phospholipase C in Thromboxane A₂‐Induced Activation of Mitogen‐Activated Protein Kinase in Astrocytoma Cells

2000 • 23 citations

The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP‐receptor

2001 • 21 citations

Two types of prostacyclin receptor coupling to stimulation of adenylate cyclase and phosphatidylinositol hydrolysis in a cultured mast cell line, BNu-2c13 cells

1993 • 20 citations