Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

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1999 • 1,597 citations

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1992 • 1,354 citations

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1998 • 1,163 citations

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1998 • 1,156 citations

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1998 • 1,054 citations

Octreotide

1996 • 956 citations

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1991 • 879 citations

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1996 • 758 citations

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1999 • 545 citations

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1997 • 479 citations

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1995 • 432 citations

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1998 • 396 citations

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1999 • 345 citations

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1993 • 321 citations

Fluorescence imaging spectroscopy and microscopy

1997 • 289 citations

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1999 • 276 citations

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1998 • 213 citations

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1996 • 213 citations

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1996 • 169 citations

Quantum efficiency independence of the time integrated emission from a fluorescent molecule

1976 • 169 citations

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1998 • 140 citations

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1998 • 120 citations

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1999 • 119 citations

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1999 • 118 citations

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1997 • 118 citations

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1989 • 106 citations

Interferon-gamma induces receptor dimerization in solution and on cells.

1993 • 102 citations

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1994 • 91 citations

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1997 • 90 citations

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1996 • 89 citations

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1997 • 82 citations

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1998 • 80 citations

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1999 • 61 citations

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1999 • 51 citations

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2013 • 51 citations

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1999 • 44 citations

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1997 • 30 citations

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1997 • 28 citations

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1999 • 15 citations

Deleted Work

1955 • 0 citations