Rapid Desensitization of the Serotonin_2C Receptor System: Effector Pathway and Agonist Dependence

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

5-Hydroxytryptamine receptors

2001 • 693 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

5‐Hydroxytryptamine Receptors

1993 • 524 citations

Desensitization of G-protein-coupled Receptors

1999 • 510 citations

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

1998 • 502 citations

α1-Adrenoceptor subtypes

1999 • 388 citations

μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

1997 • 218 citations

Differential Effects of CC Chemokines on CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus

1999 • 186 citations

Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

2000 • 169 citations

β2-Adrenergic Receptor Desensitization, Internalization, and Phosphorylation in Response to Full and Partial Agonists

1997 • 156 citations

Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

2001 • 141 citations

RNA‐editing of the 5‐HT_2C receptor alters agonist‐receptor‐effector coupling specificity

2001 • 139 citations

Interaction of Arrestins with Intracellular Domains of Muscarinic and α2-Adrenergic Receptors

1997 • 139 citations

Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.

1998 • 136 citations

Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems.

1994 • 130 citations

Agonist-induced Phosphorylation of the Angiotensin II (AT1A) Receptor Requires Generation of a Conformation That Is Distinct from the Inositol Phosphate-signaling State

2000 • 104 citations

The elusive nature of intrinsic efficacy

1998 • 102 citations

The Use of Stimulus-Biased Assay Systems to Detect Agonist-Specific Receptor Active States: Implications for the Trafficking of Receptor Stimulus by Agonists

2000 • 102 citations

Influence of Receptor Number on Functional Responses Elicited by Agonists Acting at the Human Adenosine A₁Receptor: Evidence for Signaling Pathway-Dependent Changes in Agonist Potency and Relative Intrinsic Activity

2000 • 93 citations

Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-activating Factor

1997 • 83 citations

Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.

1998 • 83 citations

Increased basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization.

1995 • 70 citations

Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation.

2001 • 66 citations

Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).

2000 • 64 citations

Regulation of inducible bradykinin B1 receptor gene expression through absence of internalization and resensitization

2000 • 38 citations

Classical Hallucinogens: An Introductory Overview

1994 • 36 citations

GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (αT3-1)1Preliminary reports of these data were presented at the 2nd Colloque de la Société des Neurosciences (Poulin et al., 1995) and at the 27th meeting of the Society for Neuroscience (Drouva et al., 1997).1

1998 • 32 citations

Comparative desensitization of the human 5‐HT_2A and 5‐HT_2C receptors expressed in the human neuroblastoma cell line SH‐SY5Y

1998 • 26 citations

Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells22Abbreviations: 5-HT, 5-hydroxytryptamine; CHO, Chinese hamster ovary; PI, phosphoinositide; FLIPR, fluorimetric imaging plate reader; mCPP, m-chlorophenylpiperazine; DOI, 2,5-dimethoxy-4-iodoamphetamine hydrobromide, GPCR, G-protein-coupled receptor; and PCR, polymerase chain reaction.

2001 • 25 citations

Neurochemical Evidence That Hallucinogenic Drugs Are 5=HT1C Receptor Agonists: What Next?

1994 • 11 citations