μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy

Neurobiology of opiate abuse

1992 • 546 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells

1995 • 291 citations

Human μ opiate receptor

1994 • 286 citations

The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C

1995 • 245 citations

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.

1994 • 236 citations

Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.

1983 • 211 citations

Differential regulation by cAMP-dependent protein kinase and protein kinase C of the mu opioid receptor coupling to a G protein-activated K+ channel.

1994 • 163 citations

Differential μ Opiate Receptor Phosphorylation and Desensitization Induced by Agonists and Phorbol Esters

1996 • 162 citations

Substitution Pharmacotherapies for Opioid Addiction: From Methadone to LAAM and Buprenorphine

1994 • 146 citations

Opiate receptors

1995 • 110 citations

beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.

1988 • 106 citations

Agonist-induced Desensitization of the Mu Opioid Receptor-coupled Potassium Channel (GIRK1)

1995 • 102 citations

Regulation of Cyclic AMP by the μ‐Opioid Receptor in Human Neuroblastoma SH‐SY5Y Cells

1990 • 99 citations

Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

1993 • 85 citations

DAMGO, a μ‐opioid receptor selective agonist, distinguishes between μ‐ and δ‐opioid receptors around their first extracellular loops

1995 • 76 citations

Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.

1996 • 71 citations

Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists.

1996 • 62 citations

Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleus

1996 • 52 citations

Basal phosphorylation of μ opioid receptor is agonist modulated and Ca²⁺‐dependent

1996 • 46 citations

Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.

1994 • 46 citations

Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.

1993 • 32 citations

Ligand selectivity of cloned human and rat opioid mu receptors

1995 • 25 citations

Drug addiction and AIDS.

1991 • 25 citations

Opioid Signal Transduction in Intact and Fragmented SH‐SY5Y Neural Cells

1992 • 13 citations