Regulators of G-Protein signalling as new central nervous system drug targets

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

2000 • 1,143 citations

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

2000 • 869 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

The Regulator of G Protein Signaling Family

2000 • 586 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

2001 • 531 citations

Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1

2000 • 519 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

2001 • 448 citations

Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain

1997 • 437 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

RGS9, a GTPase Accelerator for Phototransduction

1998 • 383 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

Isolation and Genetic Analysis of Saccharomyces cerevisiae Mutants Supersensitive to G1 Arrest by a Factor and α Factor Pheromones

1982 • 322 citations

Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2

1999 • 315 citations

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1998 • 296 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

Regulation of T cell activation, anxiety, and male aggression by RGS2

2000 • 278 citations

RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III

2001 • 260 citations

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G _β5 subunits

1998 • 260 citations

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å

2001 • 260 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling

1998 • 235 citations

G‐protein mediated gating of inward‐rectifier K⁺ channels

2000 • 231 citations

RGS-PX1, a GAP for Gα _s and Sorting Nexin in Vesicular Trafficking

2001 • 226 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity

2001 • 223 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

1991 • 223 citations

RGS8 accelerates G-protein-mediated modulation of K+currents

1997 • 221 citations

GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain

1998 • 218 citations

A new family of regulators of G-protein-coupled receptors?

1996 • 209 citations

Regulator of G protein signaling proteins: novel multifunctional drug targets.

2001 • 205 citations

Structural basis of the Axin–adenomatous polyposis coli interaction

2000 • 203 citations

RGS proteins: more than just GAPs for heterotrimeric G proteins

1999 • 200 citations

Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory

2000 • 179 citations

Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 178 citations

A Point Mutation in Gαo and Gαi1Blocks Interaction with Regulator of G Protein Signaling Proteins

1998 • 172 citations

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Gα _i subunits

1996 • 166 citations

Cloning and Characterization of RGS9-2: A Striatal-Enriched Alternatively Spliced Product of the RGS9 Gene

1999 • 155 citations

Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein

1999 • 152 citations

Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

2000 • 150 citations

RGSZ1, a Gz-selective RGS Protein in Brain

1998 • 144 citations

Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity

2000 • 144 citations

Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies

1999 • 137 citations

Regulators of G Protein Signaling 6 and 7

1999 • 136 citations

Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity

2000 • 133 citations

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA

2001 • 124 citations

RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of Gzα

1998 • 122 citations

Selective Uncoupling of RGS Action by a Single Point Mutation in the G Protein α-Subunit

1998 • 116 citations

Regulators of G Protein Signaling: Rapid Changes in mRNA Abundance in Response to Amphetamine

1998 • 111 citations

Whither Goest the RGS Proteins?

1999 • 111 citations

Elevated levels of ΔFosB and RGS9 in striatum in Parkinson’s disease

2001 • 109 citations

Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein

2001 • 101 citations

Lifetime Regulation of G Protein–Effector Complex: Emerging Importance of RGS Proteins

1998 • 99 citations

Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: in vivo and in vitro studies.

1999 • 93 citations

Regional distribution of regulators of G-protein signaling (RGS) 1, 2, 13, 14, 16, and GAIP messenger ribonucleic acids by in situ hybridization in rat brain

2001 • 90 citations

Amino-terminal Cysteine Residues of RGS16 Are Required for Palmitoylation and Modulation of Gi- and Gq-mediated Signaling

1999 • 89 citations

Rapid Kinetics of Regulator of G-protein Signaling (RGS)-mediated Gαi and Gαo Deactivation

2000 • 86 citations

RGS9-1 is required for normal inactivation of mouse cone phototransduction.

2001 • 85 citations

Characterization of RGS5 in regulation of G protein-coupled receptor signaling

2001 • 84 citations

RGS mRNA Expression in Rat Striatum

1999 • 83 citations

RGS3 Is a GTPase-Activating Protein for G_iαand G_qαand a Potent Inhibitor of Signaling by GTPase-Deficient Forms of G_qαand G_11α

2000 • 81 citations

G13α-mediated PYK2 Activation

2000 • 81 citations

RGS14 is a bifunctional regulator of Gα_i/o activity that exists in multiple populations in brain

2001 • 74 citations

Endogenous Regulator of G-Protein Signaling Proteins Modify N-Type Calcium Channel Modulation in Rat Sympathetic Neurons

2000 • 74 citations

Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function

1999 • 72 citations

Structure of the RGS-like Domain from PDZ-RhoGEF

2001 • 71 citations

Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats

2001 • 68 citations

Regulators of G Protein Signaling Proteins as Determinants of the Rate of Desensitization of Presynaptic Calcium Channels

1999 • 67 citations

Solution structure of human GAIP (Gα interacting protein): a regulator of G protein signaling

1999 • 67 citations

The Scopolamine-Induced Impairment of Spatial Cognition Parallels the Acetylcholine Release in the Ventral Hippocampus in Rats

2000 • 65 citations

Region-Specific Regulation of RGS4 (Regulator of G-Protein–Signaling Protein Type 4) in Brain by Stress and Glucocorticoids:In VivoandIn VitroStudies

1999 • 62 citations

Molecular characterization of human and rat RGS 9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS 9 gene.

1998 • 62 citations

Molecular Cloning and Characterization of a Novel Regulator of G-protein Signaling from Mouse Hematopoietic Stem Cells

2001 • 59 citations

Structure of the rgRGS domain of p115RhoGEF.

2001 • 57 citations

Muscarinic Stimulation of α1E Ca Channels Is Selectively Blocked by the Effector Antagonist Function of RGS2 and Phospholipase C-β1

2000 • 54 citations

Differential regulation of G protein‐gated inwardly rectifying K⁺ channel kinetics by distinct domains of RGS8

2001 • 52 citations

Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses

2000 • 51 citations

Ca ²⁺ Elevation Evoked by Membrane Depolarization Regulates G Protein Cycle via RGS Proteins in the Heart

2001 • 44 citations

Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.

1995 • 42 citations

NMR Structure of Free RGS4 Reveals an Induced Conformational Change upon Binding Gα

2000 • 38 citations

Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain

2002 • 35 citations

Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA

2001 • 19 citations

Mechanism and specificity of G protein regulation by RGS proteins.

1999 • 3 citations